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Biomedical subjects

J Slowinski

Publications and source records attributed to J Slowinski.

5 recordsLinked to original sources
PubMed2003

Atrophy of superior cerebellar peduncle in progressive supranuclear palsy.

BACKGROUND: Pathologic changes in the superior cerebellar peduncles (SCP) are common in progressive supranuclear palsy (PSP), but atrophy of the SCP has never been systematically studied. OBJECTIVE: To investigate the SCP width in PSP cases and controls with morphometric methods. METHODS: The mean width of the SCP in transverse sections of the pons at the level of trigeminal nerve was determined in 48 PSP cases (29 men, 19 women; mean age 72.5 +/- 8.2 years) and 29 age-matched control subjects, many with neurodegenerative disorders that can be clinically mistaken for PSP. As the origin of the SCP is the cerebellar dentate nucleus, correlations were sought between SCP atrophy and severity of grumose degeneration in the dentate nucleus. RESULTS: The average width of the SCP was less in PSP (range 0.09 to 0.24 cm) than in controls (range 0.21 to 0.43 cm; Mann-Whitney U test, p < 0.001), including control cases that had been clinically misdiagnosed as PSP (range 0.26 to 0.41 cm). Severity of SCP atrophy normalized by brain weight correlated with disease duration (Spearman rank order correlation, r = 0.367, p = 0.028), suggesting that SCP atrophy is a relatively early feature of PSP. No correlation was found between grumose degeneration and SCP width. CONCLUSIONS: SCP atrophy is common in PSP and correlates with disease duration. Given that measurements of the SCP are within the resolution of MRI, it remains to be determined if SCP atrophy can be used as a diagnostic marker of PSP.

Adult↗
PubMedDate not supplied

Multimodal sex therapy for the treatment of vulvodynia: a clinician's view.

Sex therapists are often challenged when treating women with the primary diagnosis of vulvodynia or subtypes of vulvar-vestibular pain. This article presents an overview of how a sex therapist can assess problem areas related to this diagnosis and approach treatment in a practical and comprehensive fashion. What follows is based on anecdotal clinical experience of the author. It outlines a multimodal approach that includes cognitive-behavioral techniques, both individual and conjoint therapy, as well as close cooperation with physicians who provide concurrent medical management.

Cognitive Behavioral Therapy↗