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Biomedical subjects

J Slusarczyk

Publications and source records attributed to J Slusarczyk.

At least 109 records · Page 6Linked to original sources
PubMedDate not supplied

Introduction of hepatitis delta virus into Polish drug community.

The prevalence of hepatitis delta virus (HDV) infection was studied in 140 unselected intravenous drug addicts whose sera were drawn between 1985 and 1986 and in 100 addicts from whom sera were obtained between 1988 and 1989. It was observed that 1.8% of those positive for hepatitis B virus (HBV) markers from the earlier period and 23.2% of those from the later period had detectable anti-delta antibodies. Among drug addicts referred with acute or chronic HBV infection, the first evidence of HDV infection was found in 1986. We conclude that HDV infection was introduced into the Warsaw drug community in the mid 1980s.

Carrier State↗
PubMedDate not supplied

Immunopathological aspects of hepatitis type B.

Tissue samples from 180 unselected necropsy cases of various forms of hepatitis were examined by histopathology and immunofluorescence. The hepatitis forms studied included acute fulminant hepatitis (28 patients), subacute hepatitis (48 patients), acute fatal hepatitis (24 patients), chronic aggressive hepatitis (26 patients), liver cirrhosis (49 patients), and "minimal" hepatitis (5 patients). Hepatitis B surface antigen and hepatitis B core antigen were detected in 101 patients (56.1 per cent). In these, lesion-bound immune complexes of hepatitis B surface antigen were found in the liver and extrahepatic locations in 77 patients (76.2 per cent). The latter included activated germinal centers of lymph nodes and spleen, focal hyaline lesions of splenic and renal arterioles, necrotic and/or proliferative lesions of small and medium-sized arteries, and kidney glomeruli with mild proliferative and degenerative lesions. There was an inverse relation of the approximate amounts of hepatitis B surface antigen in the liver and the liver damage, the latter being directly proportional to the amount of HBS Ag immune complexes in the liver and indirectly proportional to their amount in extrahepatic locations and to the severity of lesions at these sites.

Antigen-Antibody Complex↗
PubMedDate not supplied

[Prevalence of HIV antigens in cerebrospinal fluid and in serum of patients with both asymptomatic and symptomatic HIV infection].

Prevalence of HIV-Ag in both serum and CSF has been determined in 19 HIV infected patients, including 7 patients without any symptoms or only generalized lymphadenopathy, 5 patients with ARC and 7 patients with AIDS. The results have been correlated with clinically evident neurological disorders. HIV-Ag have been detected in 9 out of 12 patients with ARC (AIDS Related Complex) and AIDS. In 8 of them neurological disorders have been present. Out of the remaining 7 patients in only one HIV-Ag has been detected in CSF (p < 025). No correlation between the presence of HIV antigen in CSF and serum has been noted.

AIDS-Related Complex↗
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[Quantitative assay of CD8+ (cytotoxic and suppressor) lymphocytes in patients with both asymptomatic and symptomatic HIV infection].

Lymphocytes CD8+ have been assayed prospectively in 245 individuals infected with HIV. Percentage and number of CD8+ have been nearly two-fold higher in asymptomatic patients or patients with lymphadenopathy than those in the control group. The number of CD8+ lymphocytes has been rapidly decreasing parallel to the progression of HIV (ARC and AIDS), while their percentage has increased--however insignificantly. There has been a positive correlation between the number of CD4+ and CD8+ cells and all clinical stages of HIV infection.

Adolescent↗
PubMedDate not supplied

[Hepatitis B among drug addicts].

In the years 1980-1988 twenty five drug addicts were identified among 1841 patients hospitalized for acute hepatitis in the Dep. of Hepatology at the Institute of Infectious and Parasitic Diseases in Warsaw. 15 drug addicts had hepatitis B and 10 had hepatitis A. It was found, that the course of acute type B hepatitis was milder in drug addicts, than among control group consisting of non-addicts.

Acute Disease↗
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[Epidemic focus of non-A, non-B viral hepatitis in a plasmapheresis unit].

Non-A, non-B hepatitis has been diagnosed in 12 blood donors in a plasmapheresis unit. The course of the disease has been symptomatic, accompanied by jaundice, fatigue, and nausea in 8 cases, and subclinical in the remaining 4 patients. Nine patients were followed-up to 2 years and only 2 patients liver biochemical tests were normalized permanently. The biopsies performed, a year after the acute phase of hepatitis period revealed chronic active disease in patients, chronic persistent hepatitis in 2 patients, acute hepatitis in one, and normal liver in one patient. Repeated liver biopsies, performed one year later, have basically shown similar lesions except one patient in whom chronic active hepatitis progressed to incipient liver cirrhosis. No symptoms of the disease have been usually noted in patients with chronic form of the disease, and liver function tests have occasionally been normal.

Blood Banks↗
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[Hepatitis B virus infection in alcoholics].

Chromosomal analysis has been carried out in 4 patients with the symptoms of hepatic coma. An analysis included lymphocytes cultured from peripheral blood. Chromosomal disorders have been assessed with two techniques: structural chromosomal aberrations test, and sister chromatid exchange (SCE) test. It has been shown that the extend of chromosomal damage in the form of the gaps, breaks, acentric chromosomes as well as the presence of ring and dicentric chromosomes, and micronuclear cells have been higher in the examined patients. Such changes may evidence DNA repair disorders, and the presence of micronuclear forms may seem an unfavourable prognosis.

Alcoholism↗
PubMedDate not supplied

Interleukin 2 receptor positive T lymphocytes in renal allograft recipients: association with CMV infection.

The number of interleukin 2 receptor positive T cells freshly isolated from peripheral blood as well as stimulated in culture with PHA was determined in renal allograft recipients with stable graft function, rejection and CMV infection. The most typical phenotype was observed during CMV infection. Patients with CMV had very low levels of circulating positive cells which responded normally to mitogen stimulation in vitro.

Cytomegalovirus Infections↗
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[Procollagen type III peptides in chronic viral hepatitis].

Blood serum concentration of procollagen type III peptides was assayed in 37 patients with chronic active hepatitis, 14 patients with persisting chronic hepatitis, and 11 normal subjects. Mean concentration of these peptides was significantly higher in patients with chronic active hepatitis than in those with persisting chronic hepatitis (25.6 +/- 11.5 ng/mL vs. 14.0 +/- 4.5 ng/mL; p < 0.001), and in individuals without lesions to the liver (25.6 +/- 11.5 ng/mL vs. 12.5 +/- 2.9 ng/mL; p < 0.001). Blood serum concentration of procollagen type III peptides may be helpful in the differential diagnosis of hepatitis.

Adult↗
PubMedDate not supplied

Affinity and concentration of anti-HIV antibodies in asymptomatic and symptomatic HIV infection.

A novel method based on dose-response curve of antibodies and employing a hyperbolic function for its description was used for the assessment of the affinity and concentration of anti-HIV antibodies in eighteen anti-HIV positive males. The patients were followed up for a period of 8 months to 5 years and affinity and concentration of antibodies were measured at least twice, at the beginning and at the end of the observation period. No correlation between antibodies affinity and the clinical stage of infection was observed, however, concentration of antibodies decreased rapidly in AIDS.

Acquired Immunodeficiency Syndrome↗
PubMedDate not supplied

[Development of autoimmune chronic active hepatitis after acute hepatitis B].

A case of the autoimmunological chronic active hepatitis following the acute HBV infection is presented. A 24-year female patient underwent HBV infection and was hospitalized one year later due to persistent abnormalities in the activity of aminotransferases. Immunosuppressive therapy improved the results of the liver functioning tests and histological picture of the liver. An appropriate diagnosis is of importance as the chronic autoimmunological hepatitis respond to the treatment with corticosteroids. Such a treatment produced an improvement in the presented case.

Acute Disease↗