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Biomedical subjects

J Solomon

Publications and source records attributed to J Solomon.

13 recordsLinked to original sources
PubMed1979

Mutilating sclerosing basal cell epithelioma.

A 59-year-old black woman presented with an ill-defined plaque on her nose. This appeared clinically suggestive of a sclerosing type of basal cell epithelioma (BCE). Microscopic sections demonstrated this diagnosis. Multiple excisions employing the microscopically controlled technique of Mohs traced the tumor deep into the nasal cartilage before histologic sections were free of tumor cells. This type of BCE deserves well planned therapy because of its destructive potential.

Basal Cell Carcinoma↗
PubMed1977

Effect of delta-9-tetrahydrocannabinol on uterine and vaginal cytology of ovariectomized rats.

The estrogen-like activity of delta-9-tetrahydrocannabinol (delta9-THC), an active component of marihuana, as measured by uterine weight gain and vaginal smear techniques in ovariectomized rats, is reflected in histological examination of uterine and vaginal tissues. Doses of 1, 2.5, and 10 milligrams of delta9-THC per kilogram elicit hypertrophy and hyperplasia of the uterus; the dose of 2.5 milligrams per kilogram is most effective. There is an increase in stratification of vaginal epithelium with doses of 2.5 and 10 milligrams per kilogram; cornifying cells are seen with 2.5 milligrams per kilogram.

Animals↗
PubMed1977

Effects of adrenalectomy on body weight and hyperglycemia in five months old Ob/Ob mice.

Observation on body weight gain, blood glucose levels, and responses to a glucose challenge in ob/ob mice adrenalectomized at five months of age, demonstrate that removal of the adrenals of older mice retains the potential to lower serum glucose levels and depress body weight gain seen in young ob/ob mice adrenalectomized at two months of age. These findings suggest that the adrenals continue to play a role in body weight gain and hyperglycemia of the ob/ob mouse up to five months of age.

Adrenalectomy↗
PubMed1977

Rapid preparation of micro sample and gas-liquid chromatographic determination of methoxychlor residues in animal tissues and water.

Methods are described for analyses of methoxychlor (2,2-bis(p-methoxyphenyl)-1,1,1-trichloroethane) in tissues of fish and invertebrate animals and in water samples. These micro methods offer economy in solvents and materials, and reduce health and fire hazards. Furthermore, the methods sufficiently reduce sample weights to allow analyses of small animals (mayflies) or animal organs. Samples are extracted in a ball-mill with n-hexane, and lipids are removed from fatty samples by freezeout. Small Florisil columns give final lipid cleanup and partial separation of methoxychlor from interfering materials. Methoxychlor is determined on a short gas-liquid chromatographic column (retention time 2.2 min). Animal tissue samples as small as 0.1 g and water samples of 5 ml can be analyzed at sensitivities of 10 and 1 ppb, respectively. Methoxychlor recoveries were 84-101% (fish and crab tissue), 92-100% (cod liver oil), and 98-107% (water) over a concentration range of 0.-10 ppm. Results obtained for fish tissue by using micro procedures agreed to within 20% of results reported by an independent laboratory using an established method.

Animals↗
PubMed1976

Effects of lithium on open field behavior in "stressed" and "unstressed" rats.

Rats were tested for 3 min per day, for 4 successive days, in an open field apparatus, 20 min after injection of either lithium chloride (2 mEq/kg) or physiological saline. In the first experiment, the open field was illuminated with moderate white light for some rats (stress condition) and dim red light for others (non-stress condition). In the second experiment, some rats received an electric foot shock 5 h before each open field test (stress condition) and others received no foot shock (non-stress condition). In both experiments, lithium significantly reduced rearing behavior in the stressed, but not the unstressed, rats. Lithium also reduced horizontal locomotion, but this effect appeared in both stressed and unstressed rats. In the second experiment, defecation was measured, and it was found that lithium-treated rats defecated less than saline-treated rats in the first session, but not in subsequent sessions, due to habituation which occurred for the saline rats.

Animals↗
PubMed1976

Treatment of advanced lymphomas with bleomycin (NSC-125066).

88 patients with far-advanced lymphomatous malignancy were treated with Bleomycin given by either intramuscular (i. m.) or intravenous (i. v.) injection according to a randomized treatment assignment. Response occurred most frequently in Hodgkin's disease (i. m. 7/24; i. v. 4/18), least often in histiocytic lymphomas (i. m. 0/8; i. v. 1/8), and with intermediate frequency in lymphocytic lymphomas (i. m. 3/16; i. v. 0/14). While toxicity was common (70%), severe toxicity was unusual (8%) with severe pulmonary toxicity occurring in four patients (three i.m.; one i.v.). All three drug associated deaths occurred in i. m. patients. Unexpected life-threatening pericarditis occurred in two i. m. treated patients. Although response and drug related deaths occurred more often in the i. m. patients, the comparison with i. v. patients was not statistically different.

Adult↗
PubMed1976

Results with CCNU in resistant Hodgkin's and non-Hodgkin's lymphoma.

72 patients with advanced malignant lymphoma resistant to standard chemotherapy were treated with 1-(2-chloroethyl)-3-cyclohexyl-l-nitrosourea (CCNU) at 130 mg/m2 orally every six weeks. Objective responses were noted in 13 of 39 evaluable patients with Hodgkin's disease, three of 15 patients with lymphocytic lymphoma, and one of seven patients with histiocytic lymphoma. Responses lasted one to 22 months (median: four months) and occurred in patients whose disease was resistant to alkylating agents, vinblastine, vincristine, corticosteroids, procarbazine, and bleomycin. Leukopenia and thrombocytopenia were frequent toxic effects of therapy.

Administration, Oral↗