[Treatment of duodenal ulcer with a new bicyclic compound: prindamin. A double-blind controlled trial].
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Biomedical subjects
Publications and source records attributed to J Soltoft.
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59 outpatients with irritable bowel syndrome participated in a randomised double-blind trial. The patients in the treatment group received three biscuits daily each containing 10 g of ordinary miller's bran, whereas the patients in the control group received wheat biscuits of a similar appearance. The treatment period was 6 weeks. 52% of the patients in the treatment group noted subjective improvement compared with 65% in the control group. The results of this trial do not support the routine use of miller's bran in irritable bowel syndrome.
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Jejunal mucosal biopsies were obtained from 13 patients with acute enteritis. Ten patients were examined again after recovery. Quantitative analysis of the findings in immunofluorescence microscopy showed a significant increase of IgA- and IgM-containing cells during acute enteritis. After recovery the number of immunoglobulin-containing cells and their distribution within the different immunoglobulin classes were within normal limits.
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