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J Soto Alvarez

Publications and source records attributed to J Soto Alvarez.

At least 19 recordsLinked to original sources
PubMed2000

[Economic evaluation of the use of diclofenac/misoprostol in the treatment of osteoarticular diseases].

OBJECTIVE: To carry out a economic evaluation of diclofenac/misoprostol in the treatment of rheumatoid arthritis and osteoartritis when comparing with diclofenac alone, diclofenac + omeprazol, and diclofenac + ranitidine. DESIGN: Cost effectiveness analysis using a decision analytic model, where the effectiveness unit was defined as the patient free of gastro-intestinal toxicity. MATERIAL AND METHODS: The effectiveness data of the four alternatives under evaluation have been obtaining from published clinical trials. In this analysis only direct medical costs have been included without incorporating indirect costs or intangible costs. The perspective chosen has been a primary care area and the time horizon 6 months. All costs are expressed in monetary units of 1998. MEASUREMENTS AND RESULTS: The cost/effectiveness ratio obtained with diclofenac/misoprostol has been a 37% lower compared with diclofenac alone (42,238 vs 67,214 ptas), a 39% compared with diclofenac + omeprazol (42,238 vs 69,058 ptas) and a 50% compared with diclofenac + ranitidine (42,238 vs 85,198 ptas). The sensitivity analysis performed has shown that diclofenac/misoprostol is the therapeutic alternative more efficient even when most influential variables are modified. CONCLUSIONS: Diclofenac/misoprostol has demonstrated to be an alternative with a better cost/effectiveness ratio, and therefore more efficient than diclofenac alone or the concomitant use of diclofenac either with omeprazol or ranitidine. The routinary use of this association will save important resources to the National Health Service.

Anti-Inflammatory Agents, Non-Steroidal↗
PubMed1993

[Oxidative hepatic metabolism in chronic alcoholics during the acute abstinence period: evaluation with antipyrine elimination].

In chronic alcoholics, while they consume ethanol, an increase in the oxidative hepatic metabolism is produced by means of an increment of microsomal enzymes induced by ethanol. In our study we have appraised this hepatic metabolism during the period of acute ethilic abstinence. This study has been performed in 20 chronic alcoholics without clinical symptoms, after five days free of ethanol drinks. The assessment of oxidative hepatic metabolism was realized by means of the measuring of corporal antipyrine clearance (by saliva elimination), being compared to those performed in a control group of ten healthy adults. Antipyrine clearance (5.5 +/- 2 l/h) is increased significatively in chronic alcoholics respect to the control group value (3.4 +/- 1 l/h) (p < 0.01). Elimination half-life of antipyrine in chronic alcoholic groups (7.6 +/- 3 h) is decreased significatively respect to the control group value (11.2 +/- 2 h) (p < 0.01). During the period of acute abstinence, the oxidative hepatic metabolism persists increased. In these patients, when we administer drugs with hepatic metabolism following the same metabolic way that antipyrine, it will be necessary to readjust the maintenance dose to attain its therapeutic effect.

Adult↗
PubMed1992

[The assessment of liver microsomal oxidative capacity via caffeine and antipyrine elimination in patients with chronic active hepatitis: preliminary results].

The hepatic metabolism of drugs in patients with chronic active hepatitis has been studied in a few occasions, finding discordant results. In our preliminary study we pretend to appraise the microsomal oxidative hepatic metabolism in 10 chronic active hepatitis HBs Ag(+) outpatients without clinical symptoms. The concentrations of both substances were measured in saliva and the caffeine and antipyrine tests of these patients were compared to control group. The difference found in the caffeine and antipyrine elimination, between the chronic active hepatitis group and the control group, have been low, without statistics significance (p > 0.1). Although, the results are preliminaries and is necessary to follow this study in many patients, probably the caffeine and antipyrine elimination are not decreased in the chronic active hepatitis without clinical symptoms. In these patients, the microsomal oxidative hepatic metabolism is not altered.

Adult↗
PubMed1991

[Importance of monitoring theophylline and caffeine plasma levels in the management of neonatal apnea].

The simultaneous determination of caffeine and theophylline plasmatic levels has been proposed when the later is used in the treatment of the newborn's apnea. The caffeine plasmatic levels have been measured in five premature newborns treated with theophylline and the percentage of caffeine respect of theophylline, appraising its possible clinic repercusion. All the patients obtained theophylline levels into the therapeutic range proposed and a good efficacy was obtained without toxicity data, but there were a great interindividual variation in the amount of caffeine derived from theophylline (range from 12 to 50%). This result suggests the convenience of monitoring both drugs, especially when toxicity appear with theophylline levels into the therapeutic range.

Apnea↗