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Biomedical subjects

J Spencer-Peet

Publications and source records attributed to J Spencer-Peet.

11 recordsLinked to original sources
PubMed1987

A simplified thin-layer chromatography system for the detection of commonly abused basic drugs.

A simple method for the detection of drugs of abuse and their metabolites in urine is described. By extraction of urine (20 mL) with a buffered ToxElut solid phase column all the commonly abused opioid drugs can be detected on a single thin-layer chromatography plate. Location of the spots is achieved by spraying the plate with iodoplatinate following acidification with dilute sulphuric acid. Sensitivity of the order of 1 mg/L is attained for most drugs.

Chromatography, Thin Layer↗
PubMed1986

An improved method for measurement of common tricyclic antidepressant drugs and their metabolites using normal phase HPLC.

A sensitive HPLC method that allows the simultaneous determination of imipramine, amitriptyline and their desmethyl metabolites, using a 10 cm straight silica cartridge column with a mobile phase consisting of 0.004% perchloric acid in methanol is presented. Detection of the eluent is at 210 nm. The drugs are back-extracted from serum, giving both a good recovery and sensitivity of at least 5 micrograms/L. This method has proved to be extremely robust and reliable, with coefficients of variation around 3% being reported.

Antidepressive Agents, Tricyclic↗