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Biomedical subjects

J Spunda

Publications and source records attributed to J Spunda.

At least 19 recordsLinked to original sources
PubMed2001

[Perioperative hypothermia and its sequelae].

UNLABELLED: Perioperative hypothermia is associated with the development of haemocoagulation, cardiovascular and metabolic disorders leading to an increased morbidity and mortality. The objective of the investigation was to assess the extent of hypothermia and its clinical and laboratory consequences. A group of 30 patients subjected to elective radical laparotomy on account of colorectal carcinoma was divided into to equivalent groups. To the first group heated infusions were administered, to the second group not heated ones. In all patients the central and peripheral temperature, rate of postoperative normalization of the temperature, postoperative thermal comfort, consumption of analgesics and biochemical and haematological parameters were monitored. RESULTS: In patients with non-heated infusions more marked and longer perioperative hypothermia was recorded with a significant alteration of the number of leucocytes and thrombocytes. In the other investigated indicators there was no significant difference between the two groups. Hypothermia did not cause serious complications in any of the patients. CONCLUSION: Although no serious clinical complications induced by hypothermia were recorded, the authors recommend an active approach and provisions for the perioperative maintenance of body temperature as a standard of contemporary perioperative care.

Adult↗
PubMed1996

[Serum levels of sialic acid in patients with type 1 diabetes mellitus in relation to the incidence of late complications].

BACKGROUND: Sialic acid is released from terminal oligosaccharide chain of some proteins of the acute phase (fibrinogen, orosomucoid, haptoglobin, etc.). Its serum concentrations have been commonly increased during acute inflammation. Its relation diabetes mellitus or late complications of the disease have been recently studied as well. The aim of our investigation was to determine serum concentrations of sialic acid in patients with diabetes mellitus Type 1 in relation to presence or absence of late diabetic complications. METHODS AND RESULTS: The authors examined a group of 62 patients treated for diabetes mellitus Type 1, mean age 28.7 +/- 9.8 years, having been treated for this disease for 11.8 +/- 8.7 years on the average. The mean level of glycated hemoglobin HbAlc was 9.08 +/- 1.84%. In 21 patients there were signs of diabetic nephropathy, seven of them already suffering from proteinuria. Retinopathy already developed in 12 patients. The mean concentration of sialic acid in the whole cohort was 1.916 +/- 0.292 mmol/litre. The correlation of serum sialic acid with age, duration of diabetes and glycated hemoglobin was not statistically significant. There was no significant difference between the serum concentration of sialic acid in patients without apparent nephropathy and those who were affected by nephropathy, or the subgroup with proteinuria (1.945 +/- 0.328 against 1.914 +/- 0.302 mmol/litre and 1.943 +/- 0.328 mmol/litre, respectively). Statistically significantly higher concentrations of serum sialic acid were found in the subgroup of patients with present retinopathy (2.085 +/- 0.244 mmol/litre against 1.890 +/- 0.270 mmol/litre, P < 0.018). CONCLUSIONS: Our findings are in agreement with the previously proved increased concentration of proteins of the acute phase in diabetic patients and correspond well to the previously proved finding of elevated serum concentration of sialic acid in diabetic patients of Type 2 with retinopathy against other patients. It may not be excluded that the serum sialic acid could be used as a marked of the risk of late complications of diabetes mellitus.

Adult↗
PubMed1996

[Risks in minimally invasive surgery from the viewpoint of the anesthesiologist].

The author draws attention to the surgical risk during operations of minimal invasive surgery. He mentions anaesthesiological aspects when defining the risk by means of internationally used classification patterns. At the same time he mentions the most important complicating diseases limiting indications of microinvasive operations.

Anesthesia↗
PubMed1976

Computer programs suitable for processing behavioral data characterized by alternation of two states.

A program system is described which is suitable for processing behavioral and psychophysiological data characterized by alternation of two states (the transition between which is instantaneous). It is adapted for a LINC D.E.C. computer and is composed of a control program and several system programs computing different statistics and performing necessary input and output operations with the data.

Behavior↗
PubMed1976

A device for evaluation of the dominant component of the EEG activity.

A setup composed of a bioanalyser and additional electronic circuits is described allowing to measure the instantaneous frequency and amplitude of the dominant component of EEG activity. Besides recording the above values on paper by means of the EEG apparatus, functions of probability density of both the amplitude and the frequency of EEG activity are estimated on-line during preadjusted time intervals, and displayed on the screen of the bioanalyser. The mutual relationship between instantaneous EEG amplitude and frequency can be expressed in two-dimensional histograms displayed on a memory scope. The system described is suitable for laboratories having no possibility to use general purpose computer on-line.

Animals↗
PubMed1976

Thiopental anaesthesia and the acid-base balance in the blood of experimental dogs.

An analysis of basic parameters representative of the acid-base balance was made in arterial blood samples from 140 clinically healthy dogs, under a general intravenous Thiopental anaesthesia. The following mean values +/- S.E.M. were obtained: pH = 7.33 +/- 0.01; pCO2 = 47.16 +/- 0.95; base excess = -2.12 +/- 0.27; buffer base = 46.63 +/- 0.37. The results showed a prevalent trend of lower values of pH, base excess and buffer base and higher values of pCO2 than those found commonly in human clinical practice. Special attention was paid to the respiratory component of the acid-base balance (ABB) revealing certain undesirable side effect of Thiopental anaesthesia.

Acid-Base Equilibrium↗
PubMed1975

A technique for on-line classification of evoked potentials into two groups according to subjective interpretation of the stimulus.

A technique is described for on-line classification of evoked potentials (EPs) into distinct groups for separate averaging according to a criterion available after the beginning of the EPs. It is suitable for analysing psychophysiological correlations (relationship between EPs and subjective perception). The system consists of a slightly modified NTA 512 B (Hungarian) average response computer (however, any CAT-computer-like device can be used in a similar way) and of an additional device. It can be used in all cases when the number of subjective judgements according to which EPs have to be classified can be limited to two (or three, when, by slightly changing the system, all quarters of memory are used).

Computers↗
PubMed1975

Evoked responses induced by random polygonal pattern presentation.

An experiment is described which was designated to test the assumption that visual EEG evoked response waveshapes in human beings may be influenced by the presentation of random shapes differing in level of their similarity and in angular position. A clear-cut difference between the blank flash and the patterns which might be determined by the presence of contours was observed. However, neither differences in EEG evoked responses referred to the shape nor to the angular position of the polygons were found.

Electroencephalography↗