Biomedical subjects

J Sroczyński

Publications and source records attributed to J Sroczyński.

At least 19 recordsLinked to original sources

PubMed1992

[Different course of myocardial infarction in old age].

For the assessment of the peculiarities of acute myocardial infarction in patients aged over 60 years 100 patients with this disease treated at the Department of Internal and Occupational Diseases, Silesian Medical Academy were compared with 100 patients aged below 60 years. The location of myocardial infarction was similar in both groups. In the younger group premature ventricular beats were more frequent while in the older group supraventricular or ventricular tachycardia and left bundle branch block were more frequent. The death rate was much higher in the older group.

Age Factors↗

PubMed1992

[Endoscopic picture of hemorrhage from the upper digestive tract in elderly patients].

The causes of upper gastrointestinal tract bleeding were analysed in 412 patients dividing them into age groups below and over 60 years. Both groups were compared using endoscopic classification of bleedings by Forrest. In the group aged over 60 years a significantly higher per cent of type II lesion was found, especially non-bleeding vascular stump protruding from the bottom of the ulcer. This lesion was associated in nearly half the cases with recurrence of bleeding. The finding of this endoscopic picture should suggest the necessity of a more radical operation, although the operative risk is higher in patients aged over 60 years.

Age Factors↗

PubMed1992

[Evaluation of the immune system in workers engaged in the production of coal derivatives].

The study involved 361 people, 161 of whom were workers of coke plants and the remaining 200 constituted the control group. The coke plant workers were divided into the exposed and non-exposed groups. All of them were subject to the following tests: rosette test, determination of B lymphocytes, determination of the concentration of IgG, IgA, IgM immunoglobulins, and NBT granulocyte reduction test only were found in group I. Subgroups Ia, IIa, IIIa were established, in which subpopulations of T, TH-helper, TS-suppressor, TH and NK (Natural Killer) lymphocytes were discovered in group Ia. The above observations can probably be associated with exposure to tar substances which contain pyrenes.

Adult↗

PubMed1991

[Effect of working conditions in the coke-processing department on the secretory function of the adrenal cortex].

In 85 randomly chosen employees of the coal tar distillation department working at least 5 years, exposed to toxic substances not exceeding MAC except tar substances and benzo(a)pyrene, whose concentrations were high, blood level of cortisol and 17 OHCS and 17 KS excretion in urine were examined. In the most exposed group cortisol level decreased and the 17 OHCS excretion augmented.

17-Hydroxycorticosteroids↗

PubMed1991

[Effect of occupational exposure in coke production on various parameters of the hematopoietic system].

The basic parameters of the erythrocytes, white blood cell and coagulation were determined in 201 workers exposed occupationally to organic substances containing benzene and its homologues. Occupational exposure to many factors during coke production, especially to high concentrations of BaP, did not cause perceptible changes in the erythrocytes. Moreover, total number of the lymphocytes was increased in the peripheral blood of exposed workers. That maybe considered as a nonspecific exposure test for the influence of the aromatic hydrocarbons. In haemostasis system the thrombocytopenia and the abnormalities of the plasma coagulation factors were revealed.

Adult↗

PubMed1991

[Effect of simultaneous exposure to fluorine and manganese on health status of workers].

The effect of fluorine and manganese on the health of workers continually exposed to these elements was studied. The concentration of the chemicals did not significantly exceed maximum allowable concentrations only during three hours of work daily. Thirty-six workers directly exposed to fluorine and manganese were examined and compared with the controls. The authors demonstrated that exceeding permissible norms did not cause evident intoxication symptoms even though working in exposure had lasted for many years. However, some changes in the activity of liver indicatory enzymes may be one of the first symptoms of this organ's damage. Frequently occurring ++periodontosis and leukoplakia of the mucous membrane needed careful stomatological prophylaxis .

Adult↗

PubMed1991

[Evaluation of hepatic microsomal enzyme activity using C-l4-labeled aminopyrine breath test in patients with diabetes mellitus type 2 treated with tolbutamide].

Among 116 diabetic patients of the District Diabetic Polyclinic in Zabrze (51 type II treated with tolbutamide++, 36 type I treated with insulin, 29 type II treated with diet only) and 30 health persons functional microsomal hepatic fraction with ABT was assessed. Classical hepatic function test were done too. Among 49% patients under examination with type II diabetes treated with tolbutamide++ statistically significant decrease of value of ABT was observed as compared with other groups. Values of classical hepatic function tests in investigated patients were within normal values. Decrease in demethylation of aminopyrine shown as the abnormality in values of ABT can be considered as early symptom of hepatocyte damage caused by tolbutamide++. ABT is valuable method of appraising the liver's detoxication function in type II diabetes. Patients treated with tolbutamide++ should not receive any other drug known as inhibitor of microsomal enzymes of the liver.

Adult↗

PubMed1991

[Blood and plasma viscosity versus claudication distance in patients with obliterative atherosclerosis of the lower limbs].

The aim of the investigations was to show the influence of increased blood and plasma viscosity on the claudication distance in patients with obliterative atherosclerosis of lower limbs. The investigations were carried out in 53 patients: 41 men and 12 women (group I, age 45-67 years). The control group consisted of 100 healthy persons (group II) with similar range of age. The rheological studies of blood were carried out by low-shear 100 Contraves viscometer, the plasma viscosity--by means of capillary viscometer. Moreover, the total lipids, alpha, pre-beta, beta-lipoproteins, triglycerides, total cholesterol, free fatty acids, fibrinogen and hematocrit of the blood were determined. The blood for above mentioned estimations was collected before testing of the claudication distance. A significant increase of blood and plasma has been shown as well as an increase of total lipids, fibrinogen, triglycerides, total cholesterol, free fatty acids. The alpha lipoproteins were significant decreased in patients with intermittent claudication compared to the controls. The claudication distance ranged 10-500 m (the mean: 143 +/- 119 m). The correlation between claudication distance and blood and plasma viscosity was significantly negative (r = -0.42, p less than 0.001 and r = -0.32, p less than 0.05 respectively). The obtained results indicated that an increase of blood and plasma viscosity in patients with obliterative atherosclerosis of lower limbs was correlated to the decrease of claudication distance.

Aged↗

PubMed1990

[Blood and plasma viscosity and the distance of intermittent claudication in patients with type II diabetes and thrombophlebitis].

In 49 patients with insulin-resistant diabetes, with ischaemia of the lower extremities blood viscosity was measured at low coagulation rates and plasma viscosity was determined also. Moreover plasma measurements were done of total lipids, alpha-, pre-beta-, and beta lipoproteins, triglycerides, total cholesterol, free fatty acids, and, besides that, the hematocrit was measured. Immediately after blood sampling for rheological and biochemical investigations the distance of intermittent claudication was measured. A rather considerable increase of blood and plasma viscosity was noted in the patients in comparison with controls, other findings included disturbances of lipid metabolism, increased fibrinogen level, and a negative correlation between the distance of intermittent claudication and blood and plasma viscosity.

Aged↗

PubMed1990

[Effect of the work environment of the coke-processing industry on the respiratory system of coke factory workers].

The influence of the working environment in a coke factory on the respiratory system of workers was examined in 253 workers employed for at least 5 years at coke production in baking ovens, or at coke sorting and processing. They were exposed to high air concentrations of benzo(a)pyrene (BaP) and tar substances as well as other numerous toxic substances e.g. benzene++ derivatives, the level of which however, did not exceed the MAC values. Medical examination comprising the MRC questionnaire and spirometry , using Godart Expirograph, was carried out Among the exposed workers the non-specific chronic respiratory diseases with obstructive symptoms and chronic bronchitis were revealed more often than in the control group such factors as tobacco smoking and the duration of work also had their influence on the frequency of respiratory diseases. The possibility of the impact of high air concentrations of BaP and carbon monoxide cannot be excluded either.

Adult↗

PubMed1990

[Evaluation of the nervous system in workers in the furnace and coal divisions of the coke-producing plants].

240 workers of coking plant exposed to noxious chemical compounds released at coke production and control group consisting of 76 persons including 48 workers without direct contact with coke production process and 28 randomly selected healthy subjects were examined. No characteristic syndrome of subjective changes was found in workers of productive sphere. However, defective neurological symptoms were more prevalent in this group as compared to the controls. The workers from the group exposed developed neurotic syndromes with vegetative disregulation symptoms two times more frequently than the controls. The changes in EEG were significantly more prevalent in the workers occupationally exposed. The prevalence of diffuse changes in EEG depended on the level of exposure to BaP.

Adult↗

PubMed1990

[Effect of work in the coke-producing plant on the circulatory system of workers].

253 coke ++ plant workers employed for over 5 years were subject to examination. From among them 207 were exposed to very high concentrations of benzo-a-pyrene (BaP) and tar substances as well as to benzene, its homologues and carbon monoxide. However, none of these concentrations exceeded MAC value. Apart from routine medical examinations resting ECG was made and when necessary propranolol test, exercise test or even coronarography. In addition, polycardiographic and ultrasonocardiographic examinations were carried out. Comparing the results obtained in the group exposed with the controls it was found that arterial hypertension, coronary insufficiency and pathologic polycardiograms were more prevalent in the workers exposed. Chronic exposure to CO, BaP and smoking habit were considered to be factors exerting a deteriorating effect on cardiac muscle.

Adult↗

PubMed1990

[Effect of occupational exposure to lead, zinc and cadmium on various indicators of the circulatory system of metallurgical workers].

386 workers occupationally exposed to Pb, Cd and Zn in metallurgical plants were examined to evaluate the influence of lead, cadmium and zinc on circulatory system. The workers were divided into groups according to age and degree of poisoning with metals. Control group included 325 persons, selected according to age, occupationally unexposed to metals. All groups of persons were subject to medical examinations including ECG. Significantly higher prevalence of systolic murmur and heart ventricles repolarization disorders was found in the group exposed irrespective of the age of particular individuals. The workers exposed aged up to 40 years develop more frequently arterial hypertension and heart rhythm disorders. The results obtained indicate that Pb, Cd and Zn adversely affect the circulatory system.

Adult↗

PubMed1990

[Attempt at early detection of coronary insufficiency in patients with diabetes mellitus].

The upper extremity cooling test has been used for early detection of coronary insufficiency in 149 patients with diabetes mellitus and hypertension aged 40 to 60 years and electrocardiograms were evaluated prior and after the test according to the Minnesota Code. Additionally, in 49 subjects of above group the positive effort test has been performed revealing positive result in 22%, 4% exhibited the positive cooling test. In the group of 100 persons with arterial hypertension in whom the effort test has not been performed the positive cooling test has been noted in 6%. In the control group of 50 patients with arterial hypertension without diabetes, as well as in 50 healthy subjects the electrocardiographic alterations after the cooling test have not been observed and in 22% the effort test was positive. In the all groups studied after the cooling test the significant increase of systolic and diastolic pressure, the acceleration of the heart rate and the increase of double product (systolic pressure + heart action) has been noted. It has been concluded that the cooling test presents simple and useful but not sensible method of early detection of coronary insufficiency in patients with diabetes mellitus or arterial hypertension in whom there are contraindications for standard effort test.

Adult↗

PubMed1990

[Long-term oxygen therapy of chronic pulmonary heart disease].

Pulmonary artery pressure was measured in 70 patients with chronic bronchitis. Those with pulmonary hypertension underwent two hours oxygen therapy (flow 10-12 l/min). Those in whom a decrease of pulmonary artery pressure was observed were qualified for long term oxygen therapy (LTOT). In 32 patients which were qualified for LTOT, after a two week period of 18 hour per day oxygen therapy a decrease of systolic pulmonary arterial pressure from 336.1 mm Hg to 30.9 mm Hg and a decrease of mean pulmonary artery pressure from 25.9 to 23.2 mm Hg was observed.

Adult↗

PubMed1990

[Characteristics of coke plants. Health and ergonomic conditions].

1300 workers were employed in that plant; 632 in production out of which 308, most exposed, worked in the baking ovens department. The hygienic examinations revealed a very high concentration of benzo(a)piren and crude tar in the air of in the baking ovens department the MAC from several to 600 times. Other harmful substances and dust, as well as the industrial noise exceeded the MAC only incidentally. The ergonomic examinations revealed the exceeding of the energetic expenditory only in the door operators of cooking ovens. The results of medical examination will be presented in subsequent papers.

Air Pollutants, Occupational↗

PubMed1990

[Studies of immune system parameters in coke plant workers].

Studies on such parameters of immunological system as lymphocyte subpopulations percentage, immunoglobulins concentration and NBT reduction test were performed in peripheral blood obtained from 232 coke plant workers. All the subjects were divided into groups according to the degree of exposure to BaP. Lymphocyte T and B percentage, immunoglobulins IgG, IgM and IgA concentration and NBT reduction test in the examined groups were not significantly different from those in the control group. However, in subjects exposed to the highest concentrations of BaP the low percentages of lymphocytes T (OKT-3) and lymphocytes TH--helper (OKT-4) were revealed when the lymphocytes T subpopulations were examined (using monoclonal antibodies in indirect immunofluorescent technique). Presumably, the alterations the percentage of lymphocytes T subpopulations depend on high BaP concentration affecting the exposed workers.

Adult↗

PubMed1989

[Usefulness of thermographic examination in the diagnosis of early peripheral ischemia of the extremities in patients with diabetes mellitus].

Vascular damage is the main complication of diabetes. An early sign of this complication is damage to the arterial and capillary vessels in the lower extremities with later impairment of peripheral blood flow. The aim of the present study was evaluation of the usefulness of thermography in the detection of early circulatory disturbances in the lower extremities during diabetes, and comparison of its results with those obtained in oscillometry. The study comprised 28 patients with type I diabetes aged from 16 to 57 years and 27 patients with type II diabetes aged from 35 to 65 years. The control group included 10 clinically health subjects in similar age group. It was found that thermographic changes were much more frequent than pains in the extremities and abnormal values of oscillometric++ index in diabetes type I and II. Nearly half the patients with evident thermographic disturbances had no oscillometric changes, and 2/3 of the patients felt no pains in the extremities.

Adolescent↗