Biomedical subjects
Publications and source records attributed to J Stamberg.
The difference in lethality to cycloheximide between actively dividing and non-dividing cells was exploited to enhance detection of auxotrophic and UV-sensitive mutants in the fungi Schizophyllum commune and Saccharomyces cerevisiae.
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In a search for an experimental procedure to synchronize meiosis in fruit bodies of Schizophyllum commune, the effect of hydroxyurea on sporulation was tested. Results indicate that hydroxyurea has an immediate and reversible effect on basidiospore sporulation, germination, and nuclear number. A tentative time schedule for meiosis is presented.
Complications arising in the application of polyethylene catheters in surgery may be reduced by their surface hydrophilization. This study describes a combination of chemical transformation and coating with a hydrophilic gel. Modified catheters were tolerated well by the patients and in contrast with the original catheters, they did not lead to the formation of thrombi or phlebitis.
Spontaneous mutation frequencies were determined for two loci in the fungus Schizophyllum commune, at meiosis and at mitosis. For both loci the meiotic frequency is significantly higher than the mitotic frequency. No correlation was found between meiotic mutagenesis and recombination of markers bracketing the mutant site. The meiotic temperature affected the spontaneous mutation frequency but not the recombination frequency in the cross examined. A number of suppressor mutations were detected for both loci examined. Almost all the suppressors are closely linked to the site they suppress. The distribution of mutations among the suppressor sites was different at meiosis and at mitosis.
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A gene which can suppress a specific mutation disruptive to nuclear migration in Schizophyllum is described. It controls the rate of migration of invading nuclei through the mutant mycelium, thus suppressing the mutant character. The gene is located between the two loci of the B incompatibility factor.
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Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.