Biomedical subjects

J Stastný

Publications and source records attributed to J Stastný.

13 recordsLinked to original sources

PubMed1991

[Fibrin tissue glue, its preparation and methods of application].

Fibrin glues used abroad are not imported to this country. Experience assembled abroad confirms the great possibilities to use them in the treatment of various tissues in all surgical disciplines. Attempts to apply this method must start by the elaboration of a similar system of glues from local raw materials. The effectiveness depends on the quality and concentration of individual components. The authors present a report on the possibility to elaborate a tissue glue from local resources using fibrinogen obtained from homologous blood or the patient's own blood. Fibrinogen USOL, Antilysin Spofa, Trombin Imuna and Calcium chloratum Spofa are readily available. The authors mention methods of the most suitable dilution of fibrinogen and methods how to obtain concentrated fibrinogen from autologous blood. They describe the preparation of both constituents of the glue for application and different methods of application. They evaluate advantages of different methods of administration. The authors describe also their own experience with the preparation and use of fibrin glue and experience with his own system of application. The advantages of fibrin tissue glue were proved by its use in different areas of surgery. Its particular importance was described in the treatment of injuries of parenchymatous organs.

Drug Compounding↗

PubMed1991

[Hemostatic and adhesive properties of fibrin tissue glue in an experiment].

The authors compared in experiments the adhesive properties and haemostatic action of the foreign preparation Tissucol with a gluing system elaborated from locally produced constituents. The lack of availability of foreign fibrin tissue glues leads to their inadequate use in our departments. Readily available local preparations can reduce this shortcoming. They are, however, not adequately used so far. The objective of the present work was to test the adhesive and haemostatic action of several gluing systems, which differ by their fibrinogen concentration. The gluing systems were created by a similar composition and concentration as Tissucol. Experiments were performed on 22 rabbits under general i.v. and i.m. anaesthesia. The adhesive properties were tested by the firmness of a glued skin autotransplant, the haemostatic action by gluing a bleeding piercing wound of the liver. The authors proved the effectiveness of all used fibrin systems which have different qualities. The properties of Tissucol were matched only by a glue with a high fibrinogen and thrombin concentration. Our presentations can reliably replace foreign fibrin glues.

Animals↗

PubMed1991

[Tissue glues and the fibrin glue system].

The authors submit a report on the present state of development of tissue glues and their use in medicine. They characterize synthetic glues and the fibrin gluing system. They draw attention to the advantages and shortcomings of both systems. The composition of the fibrin glue is analyzed and its properties are analyzed, incl. the relation to treated tissue. Attention is drawn to the favourable properties of fibrin tissue glue in the treatment of tissues, the authors evaluate its sole use as well as its use in combination with traditional suture. They also mention preparations used in the production of the glue and compare the costs of their preparation. Principles for the production of the two components and prerequisites of their wider use in future are emphasized.

Fibrin Tissue Adhesive↗

PubMed1989

[Kawasaki syndrome associated with ornithosis].

The authors report a case involving a five-month old infant with protracted fever, lymphadenitis, exanthema, diarrhoea and sudden death. At post mortem, serological proof was discovered of a significant increase in antibodies against ornithosis. Autopsy revealed signs indicative of ornithosis and, simultaneously, of changes in the sense of multisystem vasculitis, predominantly in the region of the coronary bed as characteristic of Kawasaki's syndrome.

Humans↗

PubMed1974