Electron microscope studies made on biopsy samples of the human vocal cord from patients suffering from chronic hoarseness revealed pathological changes in both the collagen fibrils and the elastic fibres. There was splitting and fracturing of the collagen fibrils and lacuna or cyst formation in the elastic fibres, or even the complete fibre degeneration. Further investigations must be undertaken in order to establish whether the changes observed are of a primary or secondary nature.

Adult↗

PubMedDate not supplied

[An ultrastructural study of sclerosed varices].

The authors describe the results of treatment by sclerosing injections, seen by electron microscopy, in an animal experiment and using human material from a volunteer. The air block technique was used to study the action of ethoxysclerol and of variglobane on the marginal vein of the rabbit ear up to 60 minutes after injection of the compound and subsequent compression. During this time a pseudo-epithelium developed, consisting of platelets in segments of veins of which the endothelium was damaged by the sclerosing compound. The thrombus which formed subsequently consisted of blood cells, cell debris and fibrin filaments. It is possible by powerful local compression, using the Winner method (1974), to prevent the appearance of a thrombus, in particular in reticular varicosities, which enables the avoidance of recurrences by recanalisation of the thrombus. Various animal experiments were used to study the action of different paravascular administrations of sclerosing compounds on the wall of the rat femoral artery and vein. Following paravascular administration, small doses of compound at low concentration already caused considerable lesions of the walls of the vessels concerned and of nerve myelin fibres. The intra-arterial injection of sclerosing compounds caused very severs local lesions of the arterial wall and embolisation of terminal vessels by dispersal of cell debris into peripheral blood flow. This caused necrosis in the corresponding regions supplied.

Animals↗

PubMedDate not supplied

[Anatomical study on the constancy of Cockett's perforating veins].

The tenet of the constancy of Cockett's perforating vessels does not hold against anatomical studies. They perforate the fascia at various levels as their relationship to Linton's line also vary. Finally, they originate, most of the time, from the communicating veins connecting the posterior leg branch and the internal saphenous vein.

Female↗

PubMedDate not supplied

[Ultrastructure of the media and biochemistry of the intercellular substance of the wall of varicose veins].

A description using electronic microscope examinations the ultrastructural modifications affecting myocytes and the intercellular substance of the walls of varicose veins. They also have an effect on the biochemical composition of the intercellular substance.

Adolescent↗

PubMedDate not supplied

[New concept of the pathogenesis of varicose disease].

The author explains his research into the ultrastructure of the pathological venous wall. From his findings he describes his conception of the pathogeny of primary varices and emphasizes the degeneration of the enzymatic origins of the collagenous tissue, inter and intrafibrillar. The muscular cell is affected and the transmission of nervous influx is carried out imperfectly.

Basement Membrane↗