PubMed Health⌕ Search

Biomedical subjects

J Steiner

Publications and source records attributed to J Steiner.

116 records · Page 7Linked to original sources
PubMedDate not supplied

The effect of acute ethanol (EtOH) exposure on protein kinase C (PKC) activity in anterior pituitary.

Alterations in the protein kinase C (PKC) pathway may interrupt anterior pituitary luteinizing hormone (LH) synthesis and/or secretion, which may impair normal reproductive function. Work by our laboratory and others has shown that EtOH has profound deleterious effects on the regulation of the hypothalamic-pituitary-gonadal (HPG) axis. The present study focuses on PKC translocation from the cytosol to the membrane of anterior pituitary after acute EtOH exposure. Serum levels of LH were measured at three time points (15, 30, and 90 min) after an IP injection of either saline or 3 g/kg EtOH in adult castrated male rats. LH levels dropped significantly (p < 0.03) in EtOH-injected compared to saline-injected control animals. In the same animals, EtOH significantly suppressed PKC localization at its active site at the pituitary cell membrane (p < 0.05). These findings suggest that the mechanism of EtOH's suppression of LH is mediated, at least in part, through a decrease in PKC translocation to the anterior pituitary cell membrane.

Animals↗
PubMedDate not supplied

Health care fraud: guilty until proven innocent.

During the summer of 1994, the special prosecutor for health care fraud of the Department of Justice (DOJ), Washington, DC, paid a visit to each of the US Attorney's offices throughout major metropolitan cities in America. Representatives of the American Hospital Association and the American Medical Association in Chicago were invited by the DOJ to meet with the special prosecutor and his assistant to discuss the implications of the DOJ's recent reassignment of health care fraud from its number 11 to its number two priority, second only to violent crime.

American Hospital Association↗
PubMedDate not supplied

Sensory experience induced by nitrous oxide analgesia.

Preliminary findings on a group of 15 dental patients, treated with nitrous oxide indicated frequent occurrence of several, well-defined sensory experiences related to various modalities. A subsequent controlled experiment carried out on 44 volunteers, inhaling a 35% N2O + 65% O2 sedative gas-mixture as well as O2 alone in two different sessions confirmed a large variety of sensations not related to external stimuli. Taste and/or odor and thermal sensations were often reported as well as changes in auditory or visual perception of the environment in addition to reports of general heaviness, relaxation or tingling.

Adolescent↗