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Biomedical subjects

J Stopyrowa

Publications and source records attributed to J Stopyrowa.

At least 19 recordsLinked to original sources
PubMed1995

[Congenital and acquired cytomegalovirus infection in infants confirmed by virologic studies].

Sixty infants in whom clinical symptoms suspected of cytomegalovirus (CMV) infection were studied. CMV infection was found in 50% of the subjects. The diagnosis was based on studies of specific antibodies and isolation of the virus from urine and/or throat swabs. In most of the children the examinations were repeated several times, and clinical observations continued for 1 to 42 months (avg. 18 months). IgM-class antibodies were detected in 26 children and in 18 the virus was isolated. In 3 infants, isolation of CMV virus was the only evidence of active infection. Persisting viruria (avg. 11 months) and long-term presence of Ig G antibodies, even to 44th month of life were also observed. Congenital infection was diagnosed in 4 infants; the remaining ones acquired the infection during the perinatal period or later. In 7 cases transfused blood cannot be excluded as the source of infection. The clinical symptoms manifested in infected and non-infected children were similar. There was a statistically significant increase in the occurrence of hepatomegaly, splenomegaly, hyperbiliru-binemia and diarrhoea in infected children. Congenital abnormalities were found in 10 infected children, including 4 cases of congenital cytomegaly.

Antibodies, Viral↗
PubMed1995

Clinical manifestation of IgA deficiency.

Thirty patients, 2-12 years of age, with selective IgA deficiency or low level of IgA were investigated. Among them we found 5 children with coeliac disease, 15 with milk protein intolerance. Recurrent respiratory tract infections, otitis, septicemia and urinary tract infections were also frequently noted.

Celiac Disease↗
PubMed1992

[Mastoiditis--a forgotten disease?].

The symptoms and clinical course of latent mastoiditis in 18. children treated in Polish-American Children's Hospital in Cracow were presented. The ultimate diagnosis of mastoiditis was based on typical findings on antrotomy and the presence of granulation on histology of the tissue obtained during the operation. The main symptoms of latent mastoiditis were: a lack of appetite, chronic or recurrent fever and failure to thrive. 11 children (61%) had experienced more than 3 episodes of acute otitis media before the diagnosis of mastoiditis was established. Bacteria most commonly isolated from the middle ear were those of Staphylococcus, Streptococcus and Proteus species. Radiograms of mastoid processes were negative in up to 45% of those children. The mean duration of antibiotic therapy was 10.7 weeks. After antrotomy complete dissolution of symptoms were observed in 14 patients (78%). It is concluded, that in the presence of symptoms suggesting latent mastoiditis, the possibility of antrotomy, which may shorten the period of ineffective antibiotic therapy, should be considered earlier.

Humans↗
PubMed1991

A case of abetalipoproteinaemia in a Polish family.

Abetalipoproteinaemia (ABLP) was diagnosed in a brother and sister, 9 and 13 years old, presenting with symptoms of malabsorption during the neonatal period. Both children showed most of the main clinical features of ABLP, including neurological, and ophthalmic symptoms, and mental retardation. Acanthocytosis of erythrocytes was almost complete in the affected children, while in most of the remaining 11 members of their three-generation family, it was found in less than 50% of red blood cells. Absence of apoprotein B and low concentrations of apo A-I and lipids were found only in ABLP-affected children. Among five siblings only the two affected children had ABLP-characteristic lipid storage in enterocytes. The latter features correlated better with clinical symptoms than did the acanthocytosis of erythrocytes.

Abetalipoproteinemia↗
PubMed1989

Chronic granulomatous disease of childhood: gastric manifestation and response to salazosulfapyridine therapy.

The case history of a 10-year-old boy with chronic granulomatous disease (CGD) and gastric obstruction is presented. First abdominal symptoms occurred at 4 years of age when antral narrowing was detected. Due to unresponsiveness to antibiotic and steroid treatment, salazosulfapyridine therapy was initiated. Objective remission was observed within 3 months and salazosulfapyridine was withdrawn after a further 6 months of therapy. At 6 years of age clinical and radiological recurrence of gastric obstruction was observed. Salazosulfapyridine was reinstated and continued as maintenance therapy. The child has been well for more than 4 years. Salazosulfapyridine therapy can be recommended as safe conservative treatment of gastric obstruction in CGD.

Child↗
PubMed1978

MVPP chemotherapy combined with radiotherapy in the treatment of Hodgkin's disease in children.

Thirty-four children with Hodgkin's disease were treated during the years 1969--75. After radiotherapy, 7--15 cycles of MVPP were given within 24--53 months. In order to avoid chronic leukopenia, leukocyte counts were made frequently during chemotherapy, and the drug doses adjusted accordingly. A complete remission was obtained in 32 of the 34 children. Two patients died because of progressive disease. Twelve of the 32 survivors have been followed for at least 5 years, and a further 12 for at least 3 years. Three children are still on chemotherapy, whereas the remaining 29 being followed are in continued complete remission.

Adolescent↗