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Biomedical subjects

J Storer

Publications and source records attributed to J Storer.

18 recordsLinked to original sources
PubMed1990

Measurement of parathyroid hormone-related protein in extracts of fetal parathyroid glands and placental membranes.

A radioimmunoassay based on an antiserum to human parathyroid hormone-related protein PTHrP(1-16) was used with PTHrP(1-34) standard to measure the concentration of immunoreactive PTHrP in extracts of fetal parathyroid glands from lambs and calves and also placental membranes obtained from several species, including man. Dilution curves from these sources were parallel to those obtained for PTHrP(1-34) standard. It was demonstrated that this parallelism was not the result of tracer damage caused by enzymic activity in the tissue extracts. Extracts of human placental membranes were subjected to high-pressure liquid chromatography with a linear acetonitrile gradient. Co-elution of cytochemical biological activity with 125I-labelled PTHrP(1-34) was noted. These results provide further evidence for both the fetal parathyroid glands and the placenta containing material resembling PTHrP which may be responsible for sustaining the activity of the placental calcium pump which maintains the fetus hypercalcaemic relative to its mother.

Animals↗
PubMed1989

Neonatal lupus in twins.

Neonatal lupus erythematosus (NLE) is a syndrome characterized by one or all of the following elements: cutaneous LE lesions, systemic disease, and congenital heart block. SS-A/Ro and SS-B/La have been implicated in the etiology of NLE, but because NLE is not uniformly manifested in all offspring of SS-A and SS-B autoantibody positive mothers, and because of the wide range of clinical manifestations associated with NLE, other contributing etiologic factors are being explored. HLA studies have revealed that infants of SS-A/Ro and SS-B/La positive mothers bearing HLA-A1, B8, DR3, DQ2, and DR52 are at greater risk of having NLE. Haplotyping in our dizygous twins supports these material HLA associations.

Antibodies, Antinuclear↗
PubMed1976

The transplacental migration and accumulation in blood of volatile organic constituents.

Gas chromatographic-mass spectrometric analysis of profiles of low molecular weight volatile organic constituents obtained from cord blood and maternal blood samples collected at birth reflect transplacentally acquired compounds. The transplacental passage of halogenated hydrocarbons, plastic components, and abnormal accumulations of compounds have been demonstrated. In the 11 paired cord blood-maternal blood samples analyzed, the relative amounts of constituents in cord blood closely correspond to those quantities present in the maternal blood. However, some of the over 100 components are present in the cord blood in significantly higher concentrations than in the maternal blood, suggesting a possible selective one-way transfer of certain constituents into the fetus. Benzene, carbon tetrachloride, and chloroform are present in quantities equal to or greater than in maternal blood. In one infant with a lumbosacral meningomyelocele abnormally high concentrations of acetone, other components, and the food preservative 2, 6-di-tert-butyl-4-methylphenol (BHT) were identified.

Benzene↗
PubMed1975

Halogenated hydrocarbons in New Orleans drinking water and blood plasma.

Volatile organics from New Orleans drinking water and pooled plasma were collected on a solid phenyl ether polymer and analyzed by gas chromatographic and mass spectrometric techniques. Thirteen halogenated hydrocarbons were identified in the drinking water. Five halogenated compounds were found in the plasma. Tetrachloroethylene and carbon tetrachloride were found in both the plasma and the drinking water. Considerable variation in the relative concentrations of the halogenated hydrocarbons was noted from day to day in the drinking water.

Adult↗