[Candida albicans meningitis in infancy].
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Biomedical subjects
Publications and source records attributed to J Ströder.
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Bacterial meningitis in our hospital too shows its maximal frequence with 30.5% in the first month of life, 25.2% of these cases being newborns. The frequent difficulties of diagnosis in this period of life are demonstrated. Predisposing factors and possible complications of meningitis are named. The principles of modern therapy are summarized.
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10 children (3--18 months old) with Vit. D Deficiency Rickets were investigated by Rebuck skin windows for their ability to elicit unspecific inflammation before and after therapy. Differences to a control group (13 children) were statistically significant. In the acute phase of the disease beginning of inflammation is retarded, reduction of polymorphonuclear leucocytes in favour of mononuclear cells is less then in controls, the absolute quantity of exsudation is reduced too. After therapy inflammation is intensified and accelerated, but exsudation is still different from control children qualitatively and quantitatively. These findings add new facts to the data already known on impaired defence mechanisms in rickets.
Case histories of 75 children aged 6 months to 14 years were analysed, hospitalisation being for purpura due to thrombocytopenia. Sex distribution, age at first manifestation, frequency of infections immediately preceding purpura, frequency of chronic forms and letality coincide with previous literature reports. A favourable influence of corticosteroids on the acute phase of disease e.g. on purpura and disposition to haemorrhage, thrombocyte qualities, spleen- and liver enlargement as well as duration of hospitalisation was not realized.
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Antiserum directed against calcium-binding protein isolated from human kidneys was used for the immunofluorescent localization of calcium-binding protein in human intestine and kidney. Frozen sections of intestine obtained by biopsy from normal persons were tested by the indirect fluorescent antibody technique. Specific fluorescence indicating the presence of calciumbinding protein was observed at both the basal and apical poles of the intestinal absorptive cells while the goblet cells appeared to fluoresce non-specifically. Treatment of rachitic children with 25-hydroxycholecalciferol generally restored the pattern of fluorescence seen in intestinal tissue from normal persons. Examinations of intestinal biopsies from uraemic patients yielded variable results.
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