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J Straneva

Publications and source records attributed to J Straneva.

5 recordsLinked to original sources
PubMed1987

New insights into the regulation of human megakaryocytopoiesis.

It is apparent that multiple cellular stages and biologic processes can be identified during megakaryocytopoiesis that are potentially subject to control by hematopoietic growth factors and marrow accessory cell populations. Two classes of megakaryocyte progenitor cells, the colony forming unit-megakaryocyte (CFU-MK) and the burst forming unit-megakaryocyte (BFU-MK), have now been detected in normal human bone marrow cells. The BFU-MK by virtue of the greater cellular content of its resultant colonies and the delayed time of appearance of these colonies appears to be a more primitive progenitor cell with a greater proliferative potential than the CFU-MK. A number of hematopoietic growth factors including megakaryocyte colony stimulating factor, (MK-CSF), recombinant erythropoietin (EPO) and granulocyte macrophage colony stimulating factor (GM-CSF) are each capable of increasing cloning efficiency of human megakaryocyte progenitor cells. It is presently unknown whether these factors act directly on the CFU-MK or whether they stimulate marrow accessory cells to elaborate growth factors that influence CFU-MK proliferation. In order to answer this question, the effect of these growth factors on the cloning efficiency of a human megakaryocytic cell line, EST-IU, was examined. Each of these factors was capable of increasing leukemia cell colony formation. One can conclude from these studies that MK-CSF, EPO, and GM-CSF act directly on cells of the megakaryocytic lineage. The physiologic significance of the lineage nonspecific effects of EPO and GM-CSF on megakaryocytopoiesis is yet to be determined. On the basis of these observations, a model of human megakaryocytopoiesis was suggested. Several factors appear able to influence multiple steps in megakaryocytic development, whereas others influence only specific stages or cellular events occurring during megakaryocytopoiesis.

Anemia, Aplastic↗
PubMedDate not supplied

How to develop and sustain a peer-mentored research work group.

Most collaborative research models in nursing focus on hierachical structures in which an identified expert or leader directs and/or guides others in conducting research. The authors propose a peer-mentored model of collaborative research that promotes collegial participation, maximizes the use of each member's expertise, and enhances skill development within the group. This article is a description of the evolution of the Dementia Research Work Group within the Decker School of Nursing at Binghamton University. Emphasis is placed on how to create and nurture a peer-mentored research work group as well as what has been learned from the process.

Humans↗