Drug prevention and HIV policy.
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Biomedical subjects
Publications and source records attributed to J Strang.
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A recently-detoxified heroin addict was exposed to a battery of drug-related stimuli which he had previously assisted in identifying as personally relevant. Skin conductance was measured during exposure to both drug-related stimuli and neutral stimulus items. The amplitude of the first skin conductance response following stimulus presentation and the number of skin conductance responses during stimulus presentation were significantly different for the drug-related and neutral stimuli. Post-exposure subjective ranking of the drug-related items differed markedly from pre-exposure ranking; and the post-exposure subjective rankings were closer to the ranked order of the measured physiological responses than the pre-exposure subjective rankings. The use of cue exposure assessment in planning treatment for relapse prevention and the possible importance of idiosyncratic cues in the environment are discussed.
A clinico-radiological assessment of seven high-dose long-term heroin addicts was undertaken to look for the presence of neuropsychological and CT scan pathology. Definite abnormalities were found in both neuropsychological and CT scan assessments in some individuals but the pattern of CT scan and neuropsychological deficit in relation to heroin addiction was not constant.
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This study investigates and compares the responses of 132 opiate addicts to a 10-day or a 21-day in-patient oral methadone withdrawal regime. For both groups, symptom severity (on the Opiate Withdrawal Scale) steadily increased through the methadone withdrawal phase, and peaked near the point of completion of the prescribed drug, declining slowly thereafter. Patients on the 10-day programme reported significantly higher peak withdrawal scores than those on the 21-day programme. Although the proportions who completed detoxification were similar, there was a significantly higher drop-out rate immediately after detoxification for the 10-day group. The possible benefits and handicaps of the two withdrawal schedules are considered and recommendations are proposed for further refinement of the present widely adopted approach.
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