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Biomedical subjects

J Straszecka

Publications and source records attributed to J Straszecka.

13 recordsLinked to original sources
PubMed1997

[Cognitive function in patients with systemic sclerosis].

Central nervous system involvement is seldom reported in patients with systemic sclerosis (SSc). Cognitive functions were determined in 21 patients with definite SSc and 42 healthy controls. Thyroid function was also measured in order to eliminate the effect of hypothyroidism on cognitive functioning. It was found that the SSc patients with normal thyroid function showed defective long-term and recent memory, learning ability, criticism, perception and visuo-perceptual skills, their simple reaction time was prolonged. Similar but less advanced cognitive defects were shown in the SSc patients with overt or latent hypothyroidism. The obtained results indicate that the central nervous system involvement is more common in patients with SSc than it has been reported earlier.

Adult↗
PubMed1996

[Investigations concerning the effect of nabumetone on gastric mucosa].

The investigations were carried out in 9 patients (6 women and 3 men) with rheumatoid arthritis or degenerative joint disease. All subjects were given 1000 mg nabumetone (NA) in a single daily dose at the evening, during 21 days. Before and after the therapeutic course, endoscopic examination of the upper digestive tract was carried out. On day at the begin and on the 22nd day of the NA treatment, the gastric transmucosal electric potential difference (PD) was determined, in (a) standard condition, (b) after intragastric application of 1000 mg NA, and (c) after a similar application of 1000 mg of acetylsalicylic acid (AAS). On the contrary to the effect caused by AAS (p < 0.001), NA did not result any significant change of the PD (p > 0.05), neither after a single nor after 21 day-long application (the lowest PD value before the NA therapeutic course was after a single NA dose -45.8 +/- 2.7 mV and after a single dose of AAS -40.4 +/- 2.45 mV; after the end of the NA therapy course the values were: after additional NA dose -46.7 +/- 3.5 mV and after AAS -40.5 +/- 2.7 mV) Endoscopically, any changes of the upper digestive tract mucosa which could be related to the NA therapeutic course were not detected.

Adult↗
PubMed1995

[Interdigestive gallbladder volume and and meal-induced gallbladder emptying in patients with diabetes].

The aim of the study was to find whether the type of diabetes and the duration of this disease causes any influence on gallbladder (GB) emptying, after exclusion of possible effect of obesity and a hyperglycaemia over 7 mmol/l (126 mg%) on this phenomenon. The investigations were carried out in 44 subjects with diabetes mellitus, among them 22 with type I and 22 with type II. These groups were divided according to disease duration: shorter or longer than 3 years. Two control groups (CI, CII) comprised each 20 healthy subjects. The age of CI and CII corresponded to the age of diabetes groups type I and II, respectively. All subgroups as well as the control groups were matched according to sex percentage structure, body mass index (BMI) and body surface (BS). In groups with type I and II diabetes, the number of cases with diabetic neuropathy was comparable. There was not found any significant (p > 0.05) influence of diabetes on the interdigestive GB volume, neither non-standardized nor standardized with regard to standard BS (1.73 m2). In comparison to the control groups, after a test meal, there was in all diabetic groups a statistically significant (0.001 > p < 0.05) reduction of GB emptying observed. This diminution was most expressed in the group with long-lasting type I diabetes.

Adult↗
PubMed1994

[Effect of misoprostol, a synthetic prostaglandin E analog, on levels of serum C-peptide in serum and glucose tolerance].

The aim of the study was to investigate whether oral application of misoprostol (MI), which is an analogue of prostaglandin E1, does change the secretion of insulin and the blood glucose level. The investigations were carried out in 15 subjects, aged 21-40 yrs, with a gastric or duodenal ulcer and without any disturbances of the digestive tract motility. In 7 of them (group A), without stated diabetes a single oral dose of 400 mg MI versus placebo (PL) and 15 min later 75 g glucose p.o., was applied in randomized order, on different days, in fasting state. In 8 subjects with mild diabetes type II (gr B) MI versus PL and after 15 min. i.v. 1.0 mg glucagon was similarly administered. In both groups the concentrations of glucose and C-peptide in blood were determined. In comparison to PL, the application of MI did not cause any statistically significant differences of C-peptide in serum and blood glucose levels neither before and after oral glucose loading nor after i.v. administration of glucagon. Statistically not significant were also the differences in AUC (p > 0.05).

Adult↗
PubMed1992

[Influence of treating hypothyroidism and hyperthyroidism upon psychical reaction time].

The aim of the study was answering the question whether determination of psychical reaction time may be useful for the monitoring of treatment of hypothyreosis and hyperthyreosis. The correlation of disease symptoms (diagnostic index for hypothyroidism after Murray and for hypothyroidism according to Crooks), concentration of triiodothyronine, thyroxine, index of free thyroxine in blood serum and Achilles tendon reflex--with the simple reaction time (srt) as well as with the choice reaction time (chrt) before and during treatment was investigated in 18 patients with primary hypothyroidism and in 24 with hyperthyroidism caused by Graves-Basedow's disease. Two control groups comprised 84 healthy persons. Either in hypothyroidism or in hyperthyroidism the srt and chrt was significantly prolonged. The substitution therapy in hypothyroidism resulted in a normalization of both parameters. On the other hand, administration of thiamazole, especially in the early period of treatment of hyperthyroidism, further prolonged the srt and chrt. A shortening of the time of each of the two reactions occurred, however, when the restoration of euthyroidism was achieved, which was accompanied by reduction of thiamazole dosage. The obtained data point to the usefulness of srt and chrt determination for the diagnosis and therapy monitoring of functional disturbances of the thyroid gland.

Adult↗
PubMed1992

[Effect of diabetes mellitus type 1 on electric resistance of the skin and galvanic skin response].

Basal electrical resistance of the skin and the galvanic skin response were determined in 102 patients with type I (insulin-dependent) controlled diabetes mellitus. The control group consisted of 121 healthy subjects of the same age and sex distribution. The results obtained imply that diabetes mellitus causes an increase of electrical resistance of the skin, a prolongation of the latency time and or even lacking of the galvanic skin response.

Adult↗
PubMed1991

[Effect of work load on arteriosclerosis risk factors in employees of 2 Upper Silesia industries].

Investigations were undertaken to estimate various energy expenditure during professional work on incidence of hypertension, overweight, obesity, hyperuricaemia and hypercholesterolemia in workers of two enterprises in Upper Silesia. The study was carried out in 1957 individuals (1392 male, 565 female) divided into 5 groups according to the hardness of their work. Serum level of uric acid and cholesterol was determined in all investigated subjects. Incidence of hypertension, overweight and obesity was estimated. It has been stated that incidence of hypertension, hypercholesterolaemia, overweight and obesity in men and hyperuricaemia in both sexes decreased with hardness of the work. The incidence of hypertension, overweight and obesity was not related to hardness of the work in women. The authors conclude that physical activity associated with professional work can be much more in men than in women listed as a preventive measure against arteriosclerosis.

Adolescent↗
PubMed1990

[Acetylation phenotype as a risk factor of diabetic neuropathy].

Acetylation phenotype was determined in 184 diabetics: 102 patients with Type I (insulin-dependent) and 82 patients with Type II (non-insulin-dependent) diabetes mellitus, who underwent complex investigations to assess the development of sensorimotor and autonomic neuropathy. The control group consisted of 121 healthy subjects of the same age distribution. The results obtained imply that the slow acetylation phenotype may be considered as a significant risk factor of diabetic neuropathy.

Acetylation↗