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Biomedical subjects

J Stuart

Publications and source records attributed to J Stuart.

At least 199 records · Page 11Linked to original sources
PubMed1974

Training of pathologists by a system of modules.

The training requirements of the individual pathology subjects within laboratory medicine are changing rapidly and there is a trend to earlier specialization. A new training scheme based on a system of 10 modules, each of six months' duration, is suggested. Six of the modules comprise obligatory specialist training while the remaining four provide an element of choice both in subject matter and timing. This allows the advantages of multidisciplinary training to be retained, despite earlier specialization, since the subjects studied need not necessarily be restricted to the traditional pathology disciplines. The system allows 20% of training time to be devoted to full-time research and has been designed to be attractive to trainees in general medicine. Modular training provides an inherently flexible system which can readily be adapted to future developments in pathology and medicine.

Education, Medical, Graduate↗
PubMed1974

Coagulation fibrinolysis in sickle-cell disease.

A study of fibrinolytic activity in sickle-cell patients during asymptomatic periods has shown a normal fibrinolytic response to exercise and local heat to the arm. During vasoocclusive crises there was no significant decrease in fibrinolytic activity. These results contrast with earlier reports of decreased fibrinolysis during crisis and a suggestion that fibrinolytic activators might be of value in preventing vasoocclusive episodes. Patients in painful crisis showed a significant rise in fibrinogen concentration and fall in platelet count. The former may contribute to localized vascular sludging by increasing whole-blood viscosity, while the latter probably results from local trapping of platelets in areas of sickling or from subsequent splenic sequestration of damaged platelets. There was no evidence of disseminated, as opposed to localized, intravascular coagulation during crisis.

Adolescent↗
PubMed1973

Screening for abnormal haemoglobins: a pilot study.

A pilot study has been made of the implication of screening for abnormal haemoglobins in immigrant schoolchildren. An abnormality was detected by capillary blood haemoglobin electrophoresis in 8.4% of 6,835 children and a haemoglobinopathy outpatient clinic had to be established to deal with the heavy work load which resulted. The clinic was also used to determine the value of investigating the remaining members of the family once an abnormality had been detected in one child.Healthy siblings with normal haemoglobin electrophoretic patterns and normal iron and folate levels were studied to determine a normal range for haemoglobin in relation to age for adequately nourished immigrant children. The lower limit of the normal range was close to the mean value minus 1(1/2) S.D.; by using this definition 10.3% of 280 children were subsequently found to be anaemic.Population screening of this type is desirable, but further pilot studies of patient education, genetic counselling, organization of specimen collection, data processing, and follow-up health care facilities are required before screening is extended more widely in the United Kingdom.

Adolescent↗