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Biomedical subjects

J Stumpf

Publications and source records attributed to J Stumpf.

25 records · Page 2Linked to original sources
PubMed1978

[Trichinosis: epidemiology, clinical features and diagnosis (author's transl)].

After ingestion of wild boar meat 58 patients developed typical clinical signs and symptoms of trichinosis. All patients had marked blood eosinophilia. In 45% of the patients GOT and GPT and in 62% HBDH were moderately increased, while in 76% LDH and in 86% creatine-kinase showed abnormally high values. CK-MB was increased in three patients. 92% of muscle biopsies showed typical morphological changes in skeletal muscles. Latexagglutination, complement-fixation and agar-gel diffusion tests were not reliable. In most of the examined cases clinical symptoms and histological results correlated well with the indirect haemagglutination test, the microprecipitation test with living larvae of Trichinella spiralis and evidence of specific antibodies (IgG, IgM, IgE) by indirect immunofluorescence and the ELISA technique. 25 patients were treated with thiabendazole (Minzolum), 19 of them successfully.

Alanine Transaminase↗
PubMed1978

[Serum antibody findings in trichinosis (author's transl)].

Serum samples of 66 persons who had eaten meat from a wild boar were tested two to three times within 11 months for antibodies against extracts from Trichinella larvae. Watery extract of Trichinella spiralis larvae served as antigen. Complement-fixation was of little use because of its lack of sensitivity. Indirect haemagglutination and the ELISA test (enzyme-linked immunosorbent assay) gave uncertain results only in individual cases. There was a relationship between the clinical picture and the mean antibody concentration, clearer in the ELISA test than the indirect haemagglutination one. A fall in antibody titre was observed within the period of observation in only one third of patients. Results with sera of control subjects were of only limited use in relation to the specificity of the demonstrated antibodies.

Antibodies↗