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Biomedical subjects

J Stute

Publications and source records attributed to J Stute.

6 recordsLinked to original sources

[Andrological problems with foreign workers (author's transl)].

Since 20 years more and more foreign workers are employed in the Federal Republic of Germany. In view of the innumerable so far unsolved social problems like for example housing and school problems the ambition to have many children seems to be paradox at first glance. In the home country of the men the children are in important factor of protection concerning age and illness. If these people don't succeed in getting a child of their own, they react with despair and depression. The ability of the man to guarantee the subsequent existence depends among others from the number of children he generates and this is at the same time an important way of documenting his virility. And in addition to that it may be assumed that the relations mentioned above will be enforced by religious norms.

Adult↗

[Diphenylcyclopropenone - a new strong contact sensitizer (author's transl)].

A new synthetic substance - diphenylcyclopropenone - has been proven to be responsible for contact dermatitis in three persons handling it in chemical laboratories. A student of chemistry developed a dermatitis of the hands that lasted for more than two months. Based on the case history this dermatitis was considered to be an allergic one. The sensitizing capacity of diphenylcyclopropenone was proven experimentally in guinea pigs by use of the open epicutaneous sensitization method. All 25 animals became strongly sensitive. Sensitization could also be induced by a single application of low concentrations, for example with 3% in acetone. Cross-reactions could be elicited in the sensitized animals by intermediate produts and the synthesis like alpha, alpha'-dibromdibenzylketone and the remaining procduct called "red oil". The intermediate product is a mixture of racemic d- and l-forms and a meso-form as well, whereas the "red oil" consists of polymerized carbonyl compounds, from which diphenylcyclopropenone is extracted with boiling cyclohexane. Risk of contact with the sensitizer is greatest in the last step of synthesis. Care should not only be taken while handling this new substance in chemical laboratories, but contact should also be avoided with the intermediate and end products in cases where a diphenylcyclopropenone contact allergy is present.

Adult↗

[Relationship between the skin test and the specific IgE (radio-allergo-sorbens test) in the diagnosis of inhalative allergies].

Immediate-type reactions such as asthma, pollinosis and several forms of urticaria can be regarded as type I reactions according to Coombs and Gell. Primary these diseases are caused by the immune globulin E. As skin testing is accompanied by numerous failors, there is a real possibility in increasing the diagnostic relevance by measurement of the specific IgE in serum (Radio-Allergo-Sorbens-Test = RAST; Phadebas-RAST -- Pharmacia Uppsala). There are often found divergent results and therefore this investigation was started. 1357 RAST-results (530 patients) were compared with skin tests in order to investigate the concordance of the two test-methods. The statistical analysis is performed wit "4-square-Chi2". Very good correspondence could be calculated for the pollens of Festuca elatior, Poa pratensis, horse-epithelium and housedustmite (1 0/00O significancy). 1 0/0 significancy was found for catepithelium and 5 0/0 for Birch-pollen. The advantages and the disadventages of RAST are discussed.

Asthma↗

[Nutritional habits and protein status of surgical patients during the preclinical phase].

In this study the importance of nutrition during the preoperative period has to be find out. Three methods are helpful in it: 1. anamnesis of nutrition; 2. status of the subcutaneous fat tissue by measuring the skinfolds with a Harpenden-Caliper; 3. proteinstatus. 24 patients after gastric surgery and 20 patients of a control group were investigated. There was found a loss of weight inabout half of these 24 "gastric patients" preoperatively. These special patients showed a malnutrition in their anamnesis, thin skinfolds, low serum albumin and total protein concentration and a decreased concentration of immunoglobulins. They got six times more infectious complicationes than the patients without a preoperative loss of weight. It is proposed to develop an adequate plan for preoperative and post-operative nutrition.

Blood Proteins↗