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Biomedical subjects

J Styk

Publications and source records attributed to J Styk.

At least 55 records · Page 3Linked to original sources

Absorption of exaprolol from the in-situ gastrointestinal tract of rats and dogs.

The absorption rate of the beta-adrenoceptor blocking drug, exaprolol, from the gastrointestinal tract was studied using in-situ methods in the rat and dog. Exaprolol was rapidly absorbed from the small and large intestine of rats and from the ileum of dogs. The cardiac output and regional blood flow decreased in rats to approximately one half of the original values within 30 min of the in-situ experiment. The logarithm of the amount vs time plots from dogs were linear, whereas with rats a curvilinearity appeared apparently because of the blood flow-limited absorption kinetics of this highly lipophilic drug. The data obtained suggest that exaprolol is suitable for administration in sustained release form.

Adrenergic beta-Antagonists↗