Biomedical subjects

J Suazo

Publications and source records attributed to J Suazo.

5 recordsLinked to original sources

PubMed2004

Linkage disequilibrium between MSX1 and non-syndromic cleft lip/palate in the Chilean population.

Non-syndromic cleft lip/palate (NSCLP) is a complex genetic trait. Linkage and association studies have suggested that a clefting locus could be located on chromosome 4p. Sixty Chilean families were recruited for this study; from these, we used unrelated trios to evaluate the possible linkage disequilibrium between MSX1 and NSCLP. An intragenic marker, MSX1-CA, and an extragenic marker, D4S432 at a distance of 0.8 cM from MSX1, were analyzed by means of polymerase chain-reaction with fluorescent-labeled forward primers, followed by electrophoresis on a laser-fluorescent sequencer. We carried out a transmission/disequilibrium test (TDT) for multiple alleles to evaluate the presence of linkage disequilibrium. Results showed a preferential transmission of the 169-bp allele of MSX1 (p = 0.03). Although there was no preferential transmission for the D4S432 marker, the overall extended TDT (ETDT) showed a significant result (p = 0.01). The authors' findings support the hypothesis of the contribution of MSX1 in the etiology of NSCLP in the Chilean population.

Adult↗

PubMedDate not supplied

[Acute infectious cholangitis].

AIM: To know the results in the treatment of acute infectious cholangitis (IAC) and to identify risk factors related to morbidity and mortality. MATERIAL AND METHODS: We reviewed the records of patients with AIC in a 7 year period. Clinical presentation, diagnostic methods and treatment were analyzed. RESULTS: There were 85 cases (61% females and 39% males). Abdominal pain, fever and jaundice were the symptoms most frequently observed. Choledocholithiasis was present in 75% of the cases, malignant obstruction in 12% and other causes in 13%. All patients received antibiotics and 74% underwent any form of biliary drainage. There were complications in 32% of the cases and 14% died. Malignant obstruction was related to high risk of death (OR 11.1). CONCLUSION: The IAC is a potentially life-threatening disease and is most ominous in cases of malignant occlusion of biliary tree.

Abdominal Pain↗

PubMedDate not supplied

[Open cholecystectomy in cirrhotic patients. Experience at the Salvador Zubirán National Institute of Nutrition].

BACKGROUND AIMS: To inform the morbidity and mortality observed in cirrhotic patients who underwent open cholecystectomy. METHODS: We reviewed the clinical records of 31 cirrhotics that underwent open cholecystectomy and they were compared with a control group of the same age and sex. RESULTS: Despite administration of plasma or vitamin K or both, bleeding and transfusions during surgery were observed more frequently in cirrhotics. The morbidity was 13% in the controls and 42% in the cases. Renal failure, cardiac failure and upper gastrointestinal bleeding were present only in the cirrhotics. Mortality was 16% in this group (one Child A patient and four Child B-C patients). The variable related with major morbimortality was Child B or C classification. CONCLUSIONS: Open cholecystectomy was associated with high morbimortality. The valoration and preparation before surgery must be careful, and the indication from this procedure needs to be made with caution.

Adult↗

PubMedDate not supplied

[Gastropathy caused by nonsteroidal anti-inflammatory agents].

Nonsteroidal anti-inflammatory drugs (NSAID) are widely used in current clinical practice. Several gastric lesions occur as a side effect. This review paper describes the spectrum of gastric lesions, its pathogenesis, prevalence and incidence as well as clinical data, common risk factors, treatment and the prophylaxis of NSAID gastric toxicity.

Adult↗

PubMedDate not supplied

[Case and control study of atypical manifestations in gastroesophageal reflux disease].

OBJECTIVE: To study the prevalence of atypical symptoms of gastroesophageal reflux disease (GERD) in patients with esophagitis compared to controls. METHODS: We studied consecutive patients who underwent upper endoscopy between January and August of 1997. They were classified in two groups: a) Cases, patients with endoscopic diagnosis of reflux esophagitis, and b) Controls, patients without esophagitis nor typical symptoms of GERD. They answered a questionnaire to evaluate the presence of typical and atypical symptoms of GERD. RESULTS: There were 50 cases and 50 controls. There were no intergroups differences related to gender (p = 0.2), age (p = 0.4), smoking history (p = 0.7) or history of allergic diseases (p = 0.6). The atypical symptoms of GERD were more frequent in cases (66%) than controls (42%) (OR = 2.7%, 95% CI = 1.2-6, p = 0.02). The atypical manifestations more frequent in the cases were hoarseness (OR = 9.3, CI 1.1-77), thoracic pain (4.9, 1.7-14) and globus (2.8, 0.9-9). The presence of atypical symptoms was not associated to the degree of esophagitis (p = 0.7), intensity of typical symptoms (p = 0.2), gender (0.4) or age of patients (p = 0.2). CONCLUSION: Patients with reflux esophagitis have a higher risk to develop extraesophageal disorders of the pharynx, larynx and lungs.

Adolescent↗