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Biomedical subjects

J Sutcliffe

Publications and source records attributed to J Sutcliffe.

18 recordsLinked to original sources
PubMed1991

Traumatically intruded permanent incisors: a study of treatment and outcome.

Twenty-nine traumatically intruded permanent maxillary incisors from 20 patients were examined, treated and monitored for 2 years. There was a higher proportion of males than females. The teeth intruded furthest were more frequently extracted. Those which were surgically repositioned were more frequently retained and were associated with marginal bone loss significantly less frequently than those which were passively observed, while external root resorption occurred in similar proportions in both groups. A significantly higher proportion of those teeth that were delayed in presentation were subsequently extracted, and a similar trend was found for those with immature roots at the time of the initial examination.

Alveolar Bone Loss↗
PubMed1991

Quality of life: verification and use of a self-assessment scale in two patient populations.

The study described further evaluates the use of the Holmes & Dickerson linear analogue self-assessment scale in assessing the quality of life of both in-patients and out-patients undergoing radiotherapy for the treatment of malignant disease. The scale is shown to be feasible for use in both clinical settings and to be both reliable and valid. It is quick to use, easy to score and demonstrates marked differences between the patient populations. These differences are discussed and supported on clinical grounds. The results emphasize the fact that cancer patients cannot be regarded as a homogeneous group and highlight the need for care to be planned on an individual basis. Similarly, the need for a means by which individual response can be assessed is demonstrated. It is suggested that this self-assessment technique may be of considerable value in such assessment.

Evaluation Studies as Topic↗
PubMed1987

Isotope computed tomography using cone-beam geometry: a comparison of two reconstruction algorithms.

A CT scanner has been constructed specifically to determine the three-dimensional distribution of bone mineral in the medullary cavities of the radius, ulna and femur. A source of x-rays (153Gd) and a multiwire proportional counter (MWPC) are mounted at opposite ends of a diameter of an annular mounting. The limb is placed on the axis of rotation of the annulus and a series of two-dimensional transmission projections are obtained at equal angular spacings over 360 degrees. The distribution of bone mineral is reconstructed from the projections either by the method of maximum entropy (ME) or by convolution and back projection (CBP). These two methods have been evaluated by reconstructing a single slice of a phantom, representing the forearm, from projections simulated by computer. With a clinically acceptable exposure time, the mean medullary densities of the ulna and radius were determined with systematic errors of less than 3.5% (ME) and 11% (CBP), although for the latter method of reconstruction the systematic error was reduced to less than 2% by increasing the number of views. The mean medullary densities of the ulna and radius were determined with precisions better than 2.5% (ME) and 3.5% (CBP).

Algorithms↗
PubMed1983

Escherichia coli outer membrane protein K is a porin.

Protein K is an outer membrane protein found in pathogenic encapsulated strains of Escherichia coli. We present evidence here that protein K is structurally and functionally related to the E. coli K-12 porin proteins (OmpF, OmpC, and PhoE). Protein K was found to cross-react with antibody to OmpF protein and to share 8 out of 17 peptides in common with the OmpF protein. Strains that are OmpC porin- and OmpF porin- and contain protein K as their major outer membrane protein have increased rates of uptake of nutrients and a faster growth rate relative to the parental porin- strain. The protein K-containing strains are at least 1,000-fold more sensitive to colicins E2 and E3 than is the porin -deficient strain. These data suggest that protein K is a functional porin in E. coli. The porin function of protein K was also demonstrated in vitro, using black lipid membranes. Protein K increased the conductance in these membranes in discrete, uniform steps characteristic of channels with a size of about 2 nS.

Bacterial Outer Membrane Proteins↗
PubMed1976

Hypophosphatasia. Review of 24 cases.

Radiographic analysis of 24 cases of hypophosphatasia (H) from 9 Paediatric Centres was performed. 3 cases were of neonatal (lethal), 18 cases of infantile (severe) and 3 cases of late (benign) type. Some of the patients were in reality borderline cases between these groups. In the authors' material all the patients showed radiographic signs of the disease. These were divided into diagnostic, characteristic and suggestive features. All of the patients had in common generalised (usually irregular) osteoporosis, generalised (usually irregular) metaphyseal changes, craniostenosis (13 of 18 infantile cases) or widened cranial sutures and ofter bowing of the long bones. Besides the well know radiographic features of hypophosphatasia some less well known, rare or 'new' ones such as, 1. spurs of the long bones (Bowdler sign), 2. distal femoral central metaphyseal defects and epiphyseal defects, 3. S-like deformities of the tibiae, 4. abnormal shape of the distal phalanges of the fingers, 5. multiple rib fractures and slender bones, 6. wedging of the lower thoracic and upper lumbar vertebrae, 7. partial premature fusion of the epiphyses, 8. nephrocalcinosis, 9. loss of lamina dura around the teeth, 10. variation in radiographic appearances of a pair of siblings with lethal form, and, 11. rapid changes in roentgen appearances. are discussed. In two of our patients (siblings) phosphoethanolamine was undetectable in the urine. The authors doubt if a normal skeletal survey may be present at any stage in any of the three major types of hypophosphatasia.

Adolescent↗
PubMedDate not supplied

Thenar hypoplasia with associated radiologic abnormalities.

We report on five patients who presented with unilateral or bilateral hypoplasia of the thenar eminence. X rays of the affected limbs showed varying degrees of malformation and underdevelopment of the thumb phalanges and first metacarpal bone, and of the carpal bones at the base of the thumb, indicating a developmental abnormality. Our electrodiagnostic findings were compatible with this interpretation. We suggest that this condition is part of the clinical spectrum of radial club hand (radial dysplasia) and that when seen in adults, its recognition is important in the differential diagnosis of carpal tunnel syndrome.

Adolescent↗