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Biomedical subjects

J Szymaś

Publications and source records attributed to J Szymaś.

At least 19 recordsLinked to original sources
PubMed1994

[Diagnostic significance of percutaneous needle biopsy in metastatic neoplasms of the spine].

A retrospective review of percutaneous needle biopsy due to the vertebral metastatic neoplasms performed in 92 patients treated from 1975 to 1992 at Department of Neurosurgery, K. Marcinkowski University of Medical Sciences. Thoracic biopsies constituted 45 per cent, lumbar-32 per cent, cervical-18 per cent and sacral ones 5 per cent of all procedures. An accurate diagnosis was made in 70 per cent of all cases. The highest accuracy rate was noted in lesions compromising the entire vertebral body (84 per cent) and posterior elements of the vertebrae (89 per cent). Tomographic X-rays, CT and MRI were helpful in visualization of concomitant paravertebral mass. In these cases accuracy rate of the biopsy was 82 per cent. The technique of percutaneous biopsy and histological results were also discussed.

Biopsy, Needle↗
PubMed1994

Diagnostic immunohistochemistry of tumors of the central nervous system.

The hopes of the early eighties for detecting a marker which would be specific for tumor cells as such or for a tumor of specific tissue or organ differentiation line have not been fulfilled. Thus, a tumor marker is a substance the level of which increases but which is not unique for tumor cells. The marker may be localized within the neoplastic cell or on its surface. The marker may also be produced by the tumor-surrounding tissue under the influence of the tumor. Therefore, the results of identifying the markers should be interpreted with great caution and should be always confronted with the routine results of light microscopy as well as other studies. This is so even if the results greatly enrich the diagnosis. The diagnostic procedures should be based also on fully standardized laboratory techniques (Taylor 1992).

Central Nervous System Neoplasms↗
PubMed1994

NEURO multimedial data base and management system for neuropathology.

Implementation of multimedial data base and management system for cytological, biopsy, immunological, electronmicroscopy and autopsy examinations are described. Packet NEURO was implemented on IBM compatible computers runs under NetWare network system. The packet allows to realize all basic data base operations such as: entering, search, replace and deleting of records. Adding new records uses operations of projection, selection and merging relations include the formalized and coded SNOMed topography and morphology fields. The description fields, macro- and microscopic images are collecting and managing.

Allergy and Immunology↗
PubMed1993

Multimedial data base and management system for self-education and testing the students' knowledge on pathomorphology.

The composition assumed our experience in creating and using multimedial data base of examination questions and management system, which is used for. This system is implemented on microcomputers compatible with IBM PC and works in network system Net Ware 3.11. The test questions exceeded 2000 until now. The packet consists of the two functionally individual programs: ASSISTANT, which is the administrator for the databases, and EXAMINATOR which is the executive program. This system enables to use text files and add images to each question, which are adjusted to display on standard graphics devices (VGA). Standard format of the notation files enables to elaborate the results in order to estimate the scale of answers and to find correlations between the results.

Computer-Assisted Instruction↗
PubMed1993

[PATHOLOGIST --software package for database management systems in pathology].

This article summed up 4 years experiences in the creation and working with software package for collection, processing and storage of data in the form of standard database. Software package--PATHOLOGIST--can be implemented on microcomputer compatible with IBM PC. This package manages 92 relative databases in the order to gather all possible information about performed histological, cytological, immunological examinations as well as autopsy.

Database Management Systems↗
PubMed1992

[Clinical analysis of 27 cases of primary lymphoma of the central nervous system].

Clinical analysis of 27 patients with primary central nervous system lymphoma--Out of 4397 patients with intracranial neoplasms treated in the Department of Neurosurgery Medical Academy in Poznań between years 1956-1990, 27 patients i.e. 0.6% had primary central nervous system lymphoma. The patients age ranged from 15 to 63 years. In most patients the tumour was located in the temporo-parietal region. All patients were treated surgically, and then some received radio and/or chemotherapy. In spite of combined therapy the results of treatment are unsatisfactory, the median survival time is between 2 and 4 months.

Adolescent↗
PubMed1992

[Traumatic and spontaneous cerebral hematoma].

The authors analyzed 231 patients--14% of all intracranial haematomas treated in the Department of Neurosurgery in Poznań between 1962 and 1990. The patients were divided into 3 following subgroups: I--cases of spontaneous haematomas (identified and unidentified)--30%, II--haematomas of unknown aetiology, but after mild head trauma--27%, III--traumatic haematomas--43%. Increased risk of mortality was observed in cases with intracerebral posttraumatic haematomas. These patients demonstrated diffuse cerebral oedema and multifocal contusions. In the subgroup of patients with spontaneous cerebral haematomas vascular malformation was present during operation or/and in histopathological study--65%.

Acute Disease↗
PubMed1989

[Multifocal oligodendroglioma. A case report].

A case of multifocal oligodendroglioma was described in a 51-year-old woman. Tumours were located in the parietal lobe of the right cerebral hemisphere and in the frontal lobe of the left cerebral hemisphere. Multifocal character and type of the neoplasm were determined by using computerized+ tomography and fine-needle biopsy with the patient alive. Histologic examinations of the surgical and autopsy materials confirmed multifocal development of oligodendroglioma.

Biopsy, Needle↗
PubMed1987

[Significance of immunohistochemistry for neuro-oncology. VI. Occurrence, localization and distribution of glial fibrillary acid protein (GFAP) in 820 tumors].

In a retrospective study 820 tumors were immunohistochemically examined with anti-GFAP. All 224 astrocytomas and 105 of 112 glioblastomas were, at least focally, positive. 72% of ependymomas and 64% of oligodendrogliomas contained tumor cells which expressed GFAP. In such entities the reaction is dependent on the histologic subtype. Only 26 of 114 medulloblastomas (22.8%) demonstrated scattered GFAP positive cells. GFAP was also demonstrated in the CNS in gangliogliomas, monstrocellular sarcomas, 3 of 6 PNET, one non-classifiable tumor in a child, 1 plexus papilloma, in scattered stromal cells in 15 of 26 hemangioblastomas as well as in the mature glial component of intracranial germ cell tumors. Outside of the CNS there was evidence of GFAP in 3 cases with nasal glial heterotopy and in the myxoidal part of a pleomorphic salivary gland adenoma. Neoplasms which proved negative to GFAP in our series included purely neural differentiated tumors meningioma, neurolemmomas, chordomas, paragangliomas, sarcomas, lymphomas, melanomas and carcinoma metastases. Separating GFAP-positive reactive astrocytes from the actual tumor cells has proved to be a problem in the routine use of GFAP in differential diagnosis. Absence of an immunohistochemical response does not exclude a tumor of glial origin. Tissue samples which are too small, particularly in the case of anaplastic astrocytomas and glioblastomas can give false negative results.

Astrocytoma↗
PubMed1986

Determination of the glial fibrillary acidic protein in human cerebrospinal fluid and in cyst fluid of brain tumors.

The glial fibrillary acidic protein (GFAP) have been quantitatively determined in over 200 samples of liquid content of brain tumours and in cerebrospinal fluid (CSF) of cases with various tumours of the cerebral nervous system. For establishing the GFAP value, the rocket radioimmunoelectrophoresis was used. The studies were performed in three series of patients. The GFAP value of fluids from 26 cysts of both neoplastic and non-neoplastic type had a wide range of 0.6 microgram/ml to 40 micrograms/ml. Significant elevation of GFAP was usually recorded in fluid from cysts of anaplastic tumour with astroglial differentiation. In this series of 24 cases with various brain tumours, the GFAP value of the CSF ranged from 0.2 microgram/ml to 50 micrograms/ml. In gliomas, as in astrocytoma and glioblastoma, these values were on a higher level, of over 4 micrograms/ml. In other tumours and in cerebral lesions of other aetiology, the GFAP values were lower, below 3 micrograms/ml and 0.3 microgram/ml respectively. In another series of 32 patients with brain tumour treated surgically, a significant increase of GFAP (to 30 micrograms/ml) was noted in the CSF during the first week after operation, and that was always associated with an increase of the total protein of the CSF. During the second and third week after operation, when the total protein of the CSF was reduced to a normal level, the values of GFAP were still elevated, first of all in those cases of astrocytoma and glioblastoma which were not radically excised. These findings suggest that investigation of GFAP in the CSF of patients with brain tumour may be helpful in diagnosis and prognosis.

Astrocytoma↗
PubMed1986

[Importance of immunohistochemistry for neuro-oncology. II. Localization of factor VIII-associated proteins and glial fibrillary acidic protein (GFAP) in angiomatous and sarcomatous tumors].

Immunhistochemical methods utilizing specific antibodies against Factor VIII-related antigen and glial fibrillary acidic protein were employed in studies of 48 intracranial and intraspinal tumors. Factor VIII-related antigen occurred only in endothelial cells of the vascular wall and is therefore not of importance for the differential diagnosis of CNS tumors. Isolated Factor VIII positive cells in the stroma of hemangioblastomas turned out to be mast cells which may also normally contain this substance. The GFAP positive cells in hemangioblastomas are believed to all be of astrocytic lineage. Many of the multinuclear giant cells present in monstrocellular sarcomas contained GFAP but were Factor VIII negative. Genuine fibroxanthoma of the meninges can apparently exist next to pleomorphic xanthoastrocytomas. As demonstrated by one of our cases, the demonstration of GFAP alone can successfully distinguish between them.

Antibodies, Neoplasm↗
PubMed1986

[Importance of immunohistochemistry for neuro-oncology. III. Demonstration of glial fibrillary acidic proteins (GFAP) in anaplastic astrocytomas and glioblastomas].

Expression of gliofibrillary acidic protein in 23 anaplastic astrocytomas and 33 glioblastomas has been investigated and correlated with tumor behavior as reflected in both the length of the preoperative history and in the post-operative survival time. Three degrees of positive immunoreactivity to anti-GFAP can be distinguished: positive GFAP reaction in more than 2/3 of cells; in 1/3 to 2/3 of all cells; in less than 1/3 of all cells; negative reaction. All anaplastic astrocytomas and 27 of 33 glioblastomas showed GFAP positive reactions. The proportion of highly reactive tumors is higher by anaplastic astrocytomas than by glioblastomas (7 of 33). For both astrocytomas and glioblastomas there is a tendency for a decrease in the expression of GFAP to be associated with a shorter preoperative history and with a shorter survival time. This is more prominent for astrocytomas than for glioblastomas. This finding supports the opinion expressed in previous publications that the GFAP expression is reversely related to the level of tumor anaplasticity.

Astrocytoma↗