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Biomedical subjects

J Szymborski

Publications and source records attributed to J Szymborski.

At least 19 recordsLinked to original sources
PubMed2003

Neonatal hypothyroid screening in monitoring of iodine deficiency and iodine supplementation in Poland.

UNLABELLED: Neonatal hypothyroid screening in Poland is standardised and all newborns screening data are registered in central data base in the National Institute of Mother and Child. About 400,000 newborns are screened per year for hypothyroidism (TSH) and phenylketonuria (PKU). Unfortunately, obstetric clinics still use antiseptics that contain iodine. According to our data 71% of clinics used iodine in 1998 (58% iodine tincture and 13% povidone iodine) and 58.2% (35.4 iodine tincture and 13% povidone iodine) in the year 2000. Presence of iodine resulted in over 3 times increase of a percentage of TSH levels over cut off, increasing the number of false positives in the hypothyroid screening. Analysis of TSH distribution for iodine containing and iodine free hospitals gave totally different estimation of iodine deficiency according to WHO criteria. In the group of iodine free hospitals 24 regions were classified as not deficient, 9 regions were borderline with a fraction of TSH levels over 5 mlU/l of 3-5%. 10 regions could not be analysed because all hospitals declared use of iodine. In the second group all regions were iodine deficient. TSH distribution since 1994 shows significant decrease of percentage of TSH levels over cut off from 2.23% in 1994 to 0.16 in 1997 and to 0.12 in 2000. These changes are most probably connected with successive introduction of iodine supplementation which became obligatory in 1997 and suggest that iodine supplementation covers iodine requirements during pregnancy. CONCLUSIONS: Iodine deficiency and iodine supplementation in Poland can be studied using TSH blood spot newborn screening results in correlation with data on interfering factors and in reference to modified criteria for the analytical test and the population. To reduce false positive rate in neonatal hypothyroid screening iodine containing antiseptics, particularly iodine tincture, should be withdrawn from all obstetrics clinics in Poland.

Anti-Infective Agents, Local↗
PubMed2001

Epidemiological studies on Trichinellosis among swine, wild boars and humans in Poland.

The introduction of the digestion method (the magnetic stirrer type) resulted directly in the reduction of Trichinella sp. infection among people in Poland. Pork and its products are still the main cause of human trichinellosis in Poland. However, epidemics caused by eating wild boar meat suggested that this way of the transmission of Trichinella sp. larvae to humans might be of considerable importance.

Animals↗
PubMed2001

Project of the countrywide data collecting system for neonatal hearing screening programme in Poland.

Neonatal hearing screening is becoming a standard of care in increasing number of hospitals and outpatient departments in Poland. A project of central data collecting system applicable to a neonatal hearing screening programme has been elaborated as a preparation to introducing a countrywide screening programme. The data collecting system will be based on the currently existing central system for the registration of neonatal screening tests for metabolic diseases. Data on risk factors for hearing loss and hearing screening test results will be collected. A central data collecting system for a neonatal hearing screening programme will increase the efficiency of the screening programme and facilitate epidemiological studies.

Data Collection↗
PubMed2001

[Level of retinol and beta-carotene in plasma of smoking and non-smoking women].

Cigarette smoking during pregnancy generates many oxidants and free radicals and it has been implicated in cellular damage. Retinol and its provitamin beta-carotene are natural factors protecting cells from damaging influence of free oxygen species. The aim of our study was the assessment of vitamin A and beta-carotene levels in plasma of smoking and non-smoking pregnant women. Assignment the groups was based on the concentration of serum cotinine. In the presented studies the mean level of serum cotinine in smoking pregnant women was 1326 +/- 790 micrograms/l (range 350-1930 micrograms/l). In the group of tobacco abstinents the level of cotinine was in a range of 0-60 micrograms/l. Plasma concentrations of retinol and beta-carotene were measured by high pressure liquid chromatography (HPLC). Plasma level of vitamin A was lowered by 20% and was 1.64 +/- 0.42 mumol/l and 2.06 +/- 0.58 mumol/l in smoking and abstinent groups respectively. Women who smoke during pregnancy also have significantly lower levels of beta-carotene in plasma (1.9 +/- 0.5 mumol/l) than non-smokers (2.4 +/- 0.6 mumol/l; p < 0.001). We have observed that plasma concentration of beta-carotene has decreased since 21 gestation week in smokers while in abstinent group increased during pregnancy. The increase of plasma level of beta-carotene indicates that their physiological requirement is satisfied by standard vitamins supplementation. The reduced concentrations of plasma retinol and beta-carotene suggest that consumption of these antioxidants for neutralization of free radicals present in cigarette smoking is enhanced. The observed changes indicate that vitamins intake in smoking pregnant women should be carefully controlled.

Adult↗
PubMed2001

Trichinellosis in swine and wild boars in Poland from 1993 to 1998.

The prevalence of Trichinella sp. among 97, 193, 480 swine and 309,040 wild boars was determined by artificial digestion method. Pork meat was about 6 times less infected with Trichinella sp. in the years 1997-1998 than in the years 1993-1994. In the years 1993-1994 894 positive Trichinella sp. cases (prevalence--0.0029%) in pork meat were established. The prevalence of Trichinella larvae infection in pork meat in the years 1997-1998 was 0.00030%--larvae were found in 141 cases, only.

Animals↗
PubMed2000

[Evaluation in school anti-tobacco programmes].

The National Research Institute of Mother and Child (NRIMC) school anti-tobacco programmes are presented. They are discussed with reference to the Centres for Disease Control and Prevention (CDC) guidelines and other effective school programmes to prevent tobacco use among children and young people. The general objectives of the programmes at different educational levels and the elaborated strategic recommendations are presented. The own conceptualised evaluation model of school anti-tobacco programmes is analysed, including process and outcome evaluation. The presented model clarifies concepts and procedures of planning the design and evaluation of the programme in its different stages. In our opinion, the NRIMC evaluation model can be applied in other heath promotion programmes.

Adolescent↗
PubMed1994

[Use of phototherapy for in newborns with pathologic jaundice].

An analysis was done of 596 newborns with intermediate hyperbilirubinaemia treated with phototherapy. The causes of hyperbilirubinaemia were determined. The effectiveness of phototherapy was compared in three groups of newborns: in 300 newborns irradiated by continuous method, in 178 newborns irradiated by intermittent method, and in 118 newborns treated with exchange transfusion and phototherapy. It was found that the effectiveness of phototherapy depended on the initial bilirubinaemia and was similar both after continuous irradiation and intermittent phototherapy. In one-third of the newborns subjected to phototherapy side effects were observed mainly in the form of loose stools.

Humans↗
PubMed1993

[RH and ABO incompatibility in newborns treated in a pediatric hospital].

A clinical analysis is presented of 85 cases of serological incompatibility in newborns hospitalized in neonatal diseases department within 7 years. In 35 newborns Rh incompatibility was diagnosed including 24 with the presence of anti-D antibodies, and in eight newborns antibodies were found against other Rh antigens. In 53 newborns AB0 incompatibility was diagnosed, and the overwhelming majority of mothers had 0 blood group and almost 70% of the newborns has A blood group. In all newborns pathological jaundice occurred. Among newborns with Rh incompatibility prematurity, birth weight below 2500 g, perinatal complications and low Apgar score were more frequently found. Almost 80% of the newborns with Rh incompatibility and over 60% of the newborns with AB0 incompatibility showed signs of infection, and bacterial sepsis was most frequently diagnosed.

ABO Blood-Group System↗
PubMed1993

[The course of sexual development in girls with diabetes type I in view of ultrasonographic examinations].

The gynecologic a ultrasonographic examinations in 34 insulin--dependent diabetic girls aged from 1-9 y, were performed. Diabetes duration oscillated between 1-9 y. The obtained results showed that the dynamics of sexual maturation of this girls was independent of theirs calendar age, but was conditioned by the time of obtained sexual development. The right metabolic balance of diabetes stipulates regular course of sexual maturation.

Adolescent↗
PubMed1990

[Clinical analysis of Streptococcus faecalis septicemia in children].

The clinical analysis of 59 cases of Streptococcus faecalis sepsis in infants aged 1 to 5 months has been presented. Streptococcus faecalis strains isolated from the blood were characterized by drug resistance especially against penicillin or its derivatives. The clinical picture of the Streptococcus faecalis sepsis in a majority of cases is similar to that of other Gram-positive sepsis. Meningitis, first of all purulent, was noted in twenty percent of infected children. About one third of neonates with the Streptococcus faecalis sepsis showed intrauterine infection. The mortality index in children with the Streptococcus faecalis sepsis was equal to 10.2%.

Adolescent↗
PubMed1990

[Clinical analysis of 53 cases of septicemia caused by Streptococcus viridans in children].

The clinical analysis has been performed in 53 cases of sepsis induced by Streptococcus viridans. Among children with diagnosis of sepsis majority of cases in group of older infant and children up to 2 year age was due to above infection. The S. viridans strain isolated form the blood were in 90% percentage resistant to cloxacillin , the resistance to penicillin, ampicillin and gentamicin was equal to 70%, 50% and 34% respectively. The main symptoms of the S. viridans sepsis was most frequently localized in lung. Laboratory findings most frequently revealed anemia and toxic granulation in neutrophils . Four children died due to the infection (mortality index to 7.5%).

Adolescent↗