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J T Abrams

Publications and source records attributed to J T Abrams.

25 records · Page 2Linked to original sources

The need for co-ordination of research in nutrition.

On two assumptions, first that the number of dietarily essential nutrients for Man and the common monogastric mammals is 40 and, second, that the effects of at least two dietary levels of each nutrient would have to be examined in order to cover the possible nutrient interactions, then 2(40), or approximately 10(12) diets would need to be prepared. This number is beyond human capacity within any reasonable period of time: moreover, it assumes constancy of the non-essential part of the diet. Very few of the possible nutrient interactions have been studied and, as a supplement to piecemeal studies by individual workers, a co-ordinated research programme is desirable. It is noted that, while considerable attention has been paid to the nutrition of growth, the adult stage has been very neglected: the status of adult man in particular calls for attention. Factors concerned in the planning of co-ordinated research are briefly discussed.

Animals↗

Circadian rhythms in the concentration of plasma thyroxine in vitamin A-deprived calves.

Over a period of approximately 11 months, a total of 57 24 hour experiments was performed on 5 calves. The animals were fed a vitamin A-free diet and showed the common signs of vitamin A deficiency. During each experiment blood samples were taken hourly and the plasma iodoprotein content of each sample was determined. Each set of 24 values was subjected to Fourier analysis in an attempt to elucidate 24 hour, sinusoidal rhythms in iodoprotein concentration. A rhythm was deemed to be present where the chance of random sampling producing the observed pattern of concentration was less than or equal to 0.05. 25 such rhythms were detected. As the probability of random sampling giving rise to 25 rhythms in 57 tests is extremely small, circadian rhythms are assumed to exist in vitamin A-deficient, as in normal, calves. Rhythms, the characteristics of which are described here, were observed under natural conditions of day and night, and with controlled light and darkness. It is suggested that the occurrence of the rhythms, in relation to the environmental patterns of light and darkness, is better related to other aspects of brain activity than to those concerned with vision.

Animals↗