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Biomedical subjects

J T Apter

Publications and source records attributed to J T Apter.

At least 19 recordsLinked to original sources
PubMed1982

Side Effects and toxicity of lithium.

Although lithium remains the most specific treatment for bipolar affective disorder, it should be cautiously prescribed and used only when clinically indicated. The main indications for lithium are the manic phase of bipolar affective disorder and prophylaxis of both manic and depressive episodes. Lowering serum lithium levels will markedly reduce the incidence of side effects, and patients should be maintained at the lowest possible serum level. The serum level may be as low as 0.4 mEq/L and as high as 1.5 mEq/L, depending on the clinical response of the patient and the presence of side effects. The most controversial areas are the possibility of renal toxicity and the concomitant use of lithium with neuroleptics, especially haloperidol.

Antipsychotic Agents↗
PubMed1970

A physical model for muscular behavior.

A model for muscular behavior has been developed by a generalization of the laws governing the viscoelastic behavior of polymeric materials. The model simulates events thought to take place during stretch, loading, and stimulation of muscle, whether smooth or striated. The equations of motion were solved with an analogue computer for several types of perturbation, and stress, strain, and strainrate curves were generated. Model parameters were selected by fitting experimental stress-relaxation data. The resulting equations predicted the frequency dependence of dynamic modulus and phase angle within experimental error. With appropriate boundary conditions and suitable values for model parameters, the computed results also closely resembled experimental curves of contraction velocity vs. time, isometric tension development vs. time, force-velocity curves, and temperature-tension relationships. These results call attention to the relationship between the behavior of various kinds of muscle and open the way for quantifying muscular behavior in general.

Animals↗