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J T Bickel

Publications and source records attributed to J T Bickel.

26 records · Page 2Linked to original sources
PubMed1989

Binding of soybean agglutinin lectin to prostatic hyperplasia and adenocarcinoma.

The binding of soybean agglutinin (SBA) lectin to routinely processed surgical pathology material from cases of prostatic hyperplasia, atypical hyperplasia, and adenocarcinoma was studied using an immunoperoxidase technique. Positive staining was obtained in eight of eight cases of nodular hyperplasia, eight of eight cases of atypical hyperplasia, and ten of 11 cases of adenocarcinoma. This report indicates that this lectin is not useful in distinguishing prostatic hyperplasia from adenocarcinoma.

Adenocarcinoma↗
PubMed1989

Granular cell tumor.

Explore the source record for details and available documents.

Carcinoma, Squamous Cell↗
PubMed1989

Leiomyoma of the breast.

Leiomyoma of the breast parenchyma proper is a rare neoplasm. This tumor occurs predominantly in late middle-aged women and can be clinically difficult to discern from carcinoma. Mammographically, the tumor lacks typical features of carcinoma, but this possibility cannot be absolutely excluded. Immunohistochemical, ultrastructural, and DNA characteristics are reported in a new case. Mammographic findings are reported for the first time. Immunoperoxidase findings with antibodies to muscle-specific actin, desmin, vimentin, S-100 protein, and cytokeratins, as well as the ultrastructural features, suggest a pure smooth muscle cell origin and not a myoepithelial cell origin.

Aged↗
PubMed1988

Topical vital staining of human squamous cell carcinoma xenografts in nude mice.

We propose a method for visually enhancing residual cutaneous carcinoma in excision sites using topical stains. Utilizing nude mice, topical stains were applied to fresh wound beds containing partially resected human squamous cell carcinoma xenografts. Fifteen of 18 tumors were visually enhanced using topical 1% acridine orange and ultraviolet light, while none of the seven tumors stained with 0.25% dihematoporphyrin ether and ultraviolet light were enhanced. Of the stains tested, only acridine orange proved to visually enhance tumor tissue in a fresh wound bed. This study establishes the concept of direct wound staining as an aid in the excision of cutaneous cancers.

Acridine Orange↗
PubMed1985

Squamous cell carcinoma of the uterine cervix subsequent to amebiasis.

We studied the development of a well-differentiated squamous cell carcinoma of the uterine cervix five years after cervical infection with Entamoeba histolytica by documenting the findings of specimens obtained by repeated biopsies in a 69-year-old woman. To our knowledge, this is the first report of a malignant neoplasm of the uterine cervix subsequent to amebiasis. Amebiasis superimposed on malignant neoplasms of the female genital tract has been reported before. We raise the question of a possible causal relationship between amebiasis and subsequent squamous cell carcinomas of the cervix.

Aged↗
PubMed1985

Disseminated histiocytosis X complicated by diffuse erythrophagocytosis: report of two cases.

Two children with the clinical and histopathological features of disseminated histiocytosis X became refractory to chemotherapy and a diffuse erythrophagocytic process developed. No cause of the erythrophagocytosis could be found. Pancytopenia and marked erythrophagocytosis persisted until death ensued. The relationship of this disorder to familial erythrophagocytosis is discussed.

Child, Preschool↗
PubMedDate not supplied

Immunostaining of cardiac biopsy specimens in the diagnosis of acute vascular (humoral) rejection: a control study.

The diagnosis of acute vascular (humoral) rejection in heart transplant biopsies is classically based on immunofluorescent studies of frozen tissue that show vascular staining for immunoglobulin and complement. We have noted that some pathologists have used immunostaining of formalin-fixed, paraffin-embedded tissue in testing for vascular rejection. To determine the specificity of immunostaining of heart biopsy specimens in the diagnosis of vascular rejection, we studied tissue from 68 consecutive endomyocardial biopsies from 16 patients without clinical or histologic evidence of vascular rejection. In each case, routinely processed formalin-fixed, paraffin-embedded tissue was stained for immunoglobulin G and immunoglobulin M with an avidin-biotin immunoperoxidase technique. Frozen tissue from each case was also stained for immunoglobulin G, immunoglobulin M, C3, and Clq by immunofluorescence. Immunoperoxidase stains on formalin-fixed tissue showed vascular staining for immunoglobulin in 67 of 68 (99%) of the cases. Staining was ablated if the antibodies were absorbed with their appropriate immunoglobulin. Immunofluorescent studies on frozen tissue showed no vascular staining for immunoglobulin or complement. We conclude that immunoperoxidase studies of routinely processed, formalin-fixed, paraffin-embedded tissues are nonspecific in the diagnosis of heart acute vascular rejection. The positive staining in fixed tissues may be due to labeling of passive immunoglobulins that are "fixed" in the vessels during routine processing but are washed away in techniques using frozen tissue.

Acute Disease↗