Biomedical subjects

J T Bolger

Publications and source records attributed to J T Bolger.

2 recordsLinked to original sources

PubMed1975

Heterotopic bone formation and alkaline phosphatase.

Heterotopic bone formation is osteogenesis that occurs in a part of the body that does not normally form bone. Alkaline phosphatase (orthophosphoric monoester phosphorylase) has a wide substrate specificity for catalyzing the hydrolysis of phosphate esters at an alkaline pH. The various isoenzymes are found to originate in the liver, bones, intestinal mucosa, and placenta. Numerous disorders are associated with elevations of the individual isoenzymes. The physiologic function of alkaline phosphatase is as yet unknown. The bone isoenzyme (heat labile) is found elevated in cases of heterotopic bone formation and fracture repair. Osteoblasts (bone forming cells) are unusually rich in alkaline phosphatase but the relationship of this enzyme to the process of calcification and bone formation is not clear. Alkaline phosphatase appears to be involved with the elaboration of matrix rather than with the process of mineralization in osteogenesis.

Alkaline Phosphatase↗

PubMedDate not supplied

Radiocarpal dislocation--classification and rationale for management.

Radiocarpal dislocation is a rare injury. The authors reviewed seven cases with this injury and identified two groups of patients. Type I involves a dislocation of only the radiocarpal joint, while Type II involves intercarpal dislocation also. Four patients were included in Type I dislocation (3 dorsal and 1 volar). The other three patients had Type II dislocations, all of which were volar dislocations. Two patients had evidence of injury to the median and ulnar nerves at the time of the injury and both recovered completely. Closed reduction was possible with good results in three patients with Type I dislocation. All patients with Type II dislocation required open reduction and all had residual problems. The distinction between Type I and Type II is essential in order to evaluate the full extent of the injury. Closed reduction should always be attempted in Type I dislocation. Type II dislocation should be treated by open reduction and repair of all torn ligaments.

Adult↗