PubMed Health⌕ Search

Biomedical subjects

J T Gillespie

Publications and source records attributed to J T Gillespie.

10 recordsLinked to original sources
PubMed1991

Electrophysiological studies of various graft lengths and lesion lengths in repair of nerve gaps in primates.

Electrophysiological studies were used to evaluate neurological recovery in 14 rhesus monkeys with different nerve lesion lengths and graft lengths. After exposure of both sciatic nerves in each animal, baseline evoked nerve action potentials, muscle action potentials, and muscle strength values were determined for the posterior tibial nerves. Each nerve was then crushed over a measured distance. Three weeks later, the crushed segments were resected and the defects repaired with sural nerve grafts. In seven animals, 20-mm resection sites were repaired by 4 x 20-mm grafts in one leg and by 4 x 40-mm grafts contralaterally. In the other seven animals, the lengths of resection sites were 10 mm in one leg and 30 mm contralaterally; both nerve defects in these animals were repaired by 4 x 30-mm grafts. Electrophysiological studies were repeated at one interval of either 4, 7, or 12 months after repair. Postoperative electrophysiological values were compared to baseline values and described by the mean values and by percent recovery. Muscle strength recovery was significantly better in limbs with short lesions. In animals with identical lesion lengths, lesions repaired with shorter grafts (the same length as the defect) did significantly worse than did lesions repaired with longer grafts. This may suggest that any degree of tension at the graft repair site has a deleterious effect on functional nerve regeneration. Nevertheless, it was generally found that nerve lesion length had the greatest negative effect on functional nerve regeneration.

Action Potentials↗
PubMed1984

Abnormal mammographic findings. A critical appraisal.

We performed a 1 year review of mammographic interpretations and breast biopsy experiences at Madigan Army Medical Center, correlating biopsy results with mammographic interpretations when possible. Fibrocystic mammary dysplasia was reported in two thirds of our patients, with interpretations heavily weighted toward findings of moderate or severe dysplasia. Sixteen percent of our patients had indeterminate or suspicious mammograms, and only 11 percent of the mammograms were read as normal. Of 19 patients who underwent needle-directed biopsy for nonpalpable lesions and suspicious or indeterminate mammograms, two had invasive cancer and one lobular carcinoma in situ. Our data suggest that many patients who have indeterminate mammograms are followed in preference to early biopsy if there is no palpable lesion and no high yield radiologic criteria of malignancy.

Adolescent↗
PubMed1981

Subtotal colectomy with primary anastomosis without diversion in the treatment of obstructing carcinoma of the left colon.

A small series of patients with obstruction from an adenocarcinoma of the left colon is presented. The recommended treatment in selected cases is subtotal colectomy with primary anastomosis without diversion. The morbidity and mortality in this small series was minimal compared with those reported in a much larger series of similar cases treated by bowel decompression with or without concomitant resection of the lesion. Further follow-up of this series is needed. However, this procedure should be considered seriously in selected patients with obstructing carcinoma of the left colon.

Adenocarcinoma↗
PubMed1980

Treatment of esophageal carcinoma: a retrospective review.

Two hundred fourteen patients underwent treatment for carcinoma of the esophagus between January, 1950, and July, 1978, with an over-all 5 year survival rate of 1.9%. Forty-six patients (21.5% of series) underwent esophageal resection with either esophagogastrostomy (37 patients) or colon interposition (nine patients). The operative mortality rate was 18.9% for the esophagogastrectomy group and 33% for the colon interposition patients. "Curative" resections resulted in a 14.3% 5 year survival rate. One hundred twenty-seven patients (59.3% of series) were treated by irradiation therapy, with a mean survival time of 9.6 months for patients receiving "curative" dosage (over 4,500 rads). There were no 5 year survivors in this group. Palliative procedures, such as feeding gastrostomy and palliative (less than 4,500 rads) irradiation therapy, contributed little to patient comfort or survival. We favor a palliative approach to the treatment of esophageal carcinoma and believe that, when possible, esophageal resection with esophagogastrostomy is the preferable form of therapy and offers an occasional cure.

Adenocarcinoma↗
PubMed1978

Division of the left renal vein: a safe surgical adjunct.

Ten patients have undergone surgical division of the left renal vein (LRV) during operations on the abdominal aorta. Nine were elective procedures performed during the resection of a complicated abdominal aortic aneurysm (six patients) or treatment of complete infrarenal aortic occlusion (three patients). The first patient in this series underwent emergency LRV ligation at the renal hilum for the control of hemorrhage incurred during an elective aneurysmectomy. This patient survived postoperative renal failure and myocardial infarction, but died 21 months later from another myocardial infarction. At the time of death, he had moderate renal insufficiency. None of the remaining nine patients undergoing elective LRV division experienced any apparent renal dysfunction, as measured by urine sediment, serum creatinine, blood urea nitrogen, and intravenous pyelography. Although not recommended as a routine maneuver, division of the LRV is advocated as a safe adjunct for surgical exposure in difficult aortic procedures.

Adult↗
PubMed1976

Preferred surgical treatment for alveolar cell carcinoma.

An analysis of our experience with 48 patients having bronchiolar or alveolar cell carcinoma is reported. The remarkable biological variability of this peripheral tumor has important surgical implications. Basically, two dominant clinical presentations occur. In the less common diffuse or multinodular form, prolonged survival is infrequent regardless of the therapeutic approach. Often these patients die from respiratory compromise due to the tumor itself. In the more common localized or solitary form the prognosis for cure is good, approximating 47% or higher. Based on the material presented, lobectomy is the preferred method of surgical treatment. In patients manifesting multinodular disease, surgical resection rarely seems warranted. The concept of preserving pulmonary tissue is stressed.

Adenocarcinoma, Bronchiolo-Alveolar↗
PubMedDate not supplied

Aortic mycotic abdominal aneurysm involving all visceral branches: excision and dacron graft replacement.

A 41 year-old patient with an aortic mycotic abdominal aneurysm involving all visceral branches is presented. Excision and dacron graft replacement involving limbs to the coeliac axis, superior mesenteric, and both renal arteries was accomplished successfully. The rationale for employing dacron material in infected tissue is reviewed. In our opinion, an integral aspect of its usage includes the debridement or removal of the aneurysm in conjunction with prolonged antibiotic coverage postoperatively. The patient is alive and free of apparent infection one year following surgery.

Adult↗