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Biomedical subjects

J T Lumeij

Publications and source records attributed to J T Lumeij.

At least 19 recordsLinked to original sources

The percentage of feline, canine, avian and exotic animal consultations in veterinary practice in The Netherlands in 1994 and suggested consequences for the veterinary curriculum and residency programs.

The percentage of feline, canine, avian and exotic animal consultations in 1994 was established by means of a survey among veterinary practitioners in the Netherlands. The results from the response to a questionnaire which was sent to companion animal practitioners were compared with those of an at random telephone survey and tested for reliability. Results showed that the cat tended to be the most frequently presented species in companion animal practice in the Netherlands in 1994 (46%), followed by dogs (44%) and birds and exotic animals (10%). In mixed practices these percentages were 40%, 51%, and 9% respectively. From the 'avian and exotic animal' group the following species or orders were the most important: rabbits (32%), rodents (26%), parrots (12%), pigeons (9%), songbirds (9%), ferrets (4%), others (8%). It is concluded that the veterinary curriculum should be adapted to prepare veterinary students to deal with this greater variety in pet animals species and related problems. The need to include exotic animal medicine in resident training programmes is emphasized.

Animals

Clinical diagnosis of aneurysm of the right coronary artery in a white cockatoo (Cacatua alba).

A 16-year-old male white cockatoo was presented with lethargy and a decreased appetite. Auscultation between the second and third sternal rib revealed a heart murmur, which was confirmed by electrocardiographic and phonocardiographic examination to be systolic, with a shift of the heart axis to -152 degrees. Radiographs showed lack of detail in the cranial part of the abdominal coelom, indicative of ascites and an enlarged cardiac shadow, while ultrasonographic examination revealed pericardial effusion and fluid accumulation in the cavitas peritonealis hepatica. An extra fluid-filled cavity was found at the atrioventricular junction in the right cardiac wall and colour Doppler examination demonstrated a turbulent jetstream of blood into the cavity, originating directly above the aortic valve. Non-selective angiocardiography confirmed the ultrasonographic observations. Findings were indicative of an aneurysm of the a. coronaria dextra (right coronary artery). This was confirmed by necropsy which revealed atherosclerosis to be the underlying cause.

Angiography

Susceptibility of Encephalitozoon cuniculi to several drugs in vitro.

In the light of the increased incidence of human Encephalitozoon infections and the absence of an established treatment protocol, a simple in vitro testing method to compare activities of drugs against Encephalitozoon cuniculi was developed. With this in vitro method, the 50% inhibitory concentrations of fumagillin, thiabendazole, albendazole, oxibendazole, and propamidine isethionate for E. cuniculi in rabbit kidney cells were determined. Itraconazole, toltrazuril, metronidazole, ronidazole, and ganciclovir were ineffective in this testing system.

Animals

Treponemal infections in hares in The Netherlands.

Treponemal infections in wild European brown hares (Lepus europaeus) from The Netherlands were diagnosed by means of serological tests for human syphilis and histological demonstration of spirochetes by the Bosma-Steiner silver impregnation method in histological sections of skin lesions. The treponeme should probably be classified as "Treponema paraluisleporis."

Animals

In vivo studies on the effects of ovine corticotrophin-releasing hormone, arginine vasotocin, arginine vasopressin, and haloperidol on adrenocortical function in the racing pigeon (Columba livia domestica).

This study investigates the effects of in vivo administration of pituitary stimulants in racing pigeons (Columba livia domestica). Plasma corticosterone concentrations were measured following intravenous administration of ovine corticotrophin-releasing hormone (oCRH) (0.1, 1, 10, and 100 micrograms/kg), arginine vasopressin (AVP) (0.01, 0.1, 1, and 10 micrograms/kg), arginine vasotocin (AVT) (0.01, 0.1, 1, and 5 micrograms/kg), and haloperidol (0.05, 0.5, and 5 micrograms/kg). Compared with mammals the pituitary-adrenocortical system of the pigeon appeared to be less sensitive to stimulation with oCRH, although high doses were well tolerated and gave a clear response. Both AVP and AVT stimulated corticosterone secretion, AVT in a more pronounced dose-dependent manner than AVP. The natural neurohypophysial peptide in birds, AVT, was less well tolerated in high doses than AVP. The clear response to haloperidol indicates that the hypothalamo-pituitary-adrenocortical system is under dopaminergic inhibition. Of the pituitary stimulants tested AVP (10 micrograms/kg) and oCRH (100 micrograms/kg) are the most appropriate for testing the integrity of the pituitary-adrenocortical system in the pigeon.

Adrenal Cortex

Evaluation of antibiotics for racing pigeons (Columba livia var. domestica) available in The Netherlands.

Antibiotics and chemotherapeutics marketed for use in racing pigeons (Columba livia var. domestica) were evaluated by comparing the dosages and indications given by the manufacturers with the data obtained by pharmacokinetic, bacteriological and efficacy studies. This comparison showed that only three of the recommended dosages and indications of the 60 formulations marketed in The Netherlands are scientifically sound and in accordance with the literature. It is to be expected that the majority of the antimicrobials for pigeons will not satisfy the requirements for final registration as a pigeon therapeutic under the Dutch Veterinary Medicines Act of 1985. Several factors affecting drug availability are discussed, such as the different routes of administration and the influence of food. The public health aspects of the consumption of medicated pigeons is also discussed. Although there is no legislation with regard to this subject, a recommended withdrawal time of 10 days for the majority of the antimicrobials seems advisable.

Animals

Evaluation of anthelmintics, antiprotozoal drugs and ectoparasiticides for racing pigeons (Columba livia var. domestica) available in The Netherlands.

Anthelmintics, antiprotozoal drugs and ectoparasiticides specially marketed for use in racing pigeons (Columba livia var. domestica) were evaluated by comparing dosages and indications given by the producers with data obtained from efficacy studies or empirical data. Of a total of 63 products, 59% were in accordance with the literature. Fifty-nine percent of the dosages and indications of anthelmintics were in accordance with scientifically obtained data, while for trichomonacides, coccidiostats and ectoparasiticides the figures were 47%, 59% and 100% respectively. Public health aspects of the consumption of medicated pigeons are discussed.

Animals

In vitro nitroimidazole resistance of Trichomonas gallinae and successful therapy with an increased dosage of ronidazole in racing pigeons (Columba livia domestica).

Six out of eight different Trichomonas gallinae strains isolated from racing pigeons proved to be resistant to the nitroimidazole drugs ronidazole, carnidazole and metronidazole. The minimal cytocidal concentration of ronidazole was determined in in vitro experiments. Moreover, a therapeutic dose for ronidazole was determined for the control of trichomoniasis in pigeons from which the resistant T. gallinae strains were isolated. It was a 5-fold increase of the recommended ronidazole dosage which eliminated the infection in affected pigeons.

Animals

[A comparison of parrot food commercially available in The Netherlands].

The composition of a number of parrot foods commercially available in the Netherlands was put to the test for the (partly hypothetical) needs of the larger psittacine birds such as African Grey parrots, Amazon parrots, macaws and cockatoos. These studies showed that the majority of the foods is multideficient. When the deficient foods are supplied to parrots without any additions, this will give rise to the appearance of disease. However, some of the products recently put on the market (Bogena and Kasper Fauna Food) comply better with the requirements of a 'complete parrot food'. As regards public enlightenment, food producers, petshops, consumer organisations and veterinarians are obviously responsible.

Animal Feed