Sharp, John T. (Harvard Medical School, Boston, Mass.). Amino sugars in L forms of bacteria and pleuropneumonia-like organisms. J. Bacteriol. 86:692-701. 1963.-Studies of several bacterial L forms and their parent bacteria have revealed similar amino sugars in the two forms of microorganisms, with the exception that muramic acid was absent from the streptococcal and staphylococcal L forms. In contrast, muramic acid was found in a Proteus L form. Some of the properties of the muramic acid component in the Proteus L form are described. The solubility of this material was observed to be very different in the L form as compared with the bacterium. Some implications of this observation are discussed. Two strains of pleuropneumonia-like organisms did not contain muramic acid.

Amino Sugars↗

PubMed1963

PREMATURE MITRAL VALVE CLOSURE: A HEMODYNAMIC EXPLANATION FOR ABSENCE OF THE FIRST SOUND IN AORTIC INSUFFICIENCY.

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Aortic Valve Insufficiency↗

PubMed1961

Studies of arthritis and other lesions induced in rats by injection of mycobacterial adjuvant. V. Changes affecting the skin and mucous membranes. Comparison of the experimental process with human disease.

A generalized disease is induced experimentally in the rat by administration of Freund's adjuvant. The primary clinical and pathologic lesions are arthritis, periarthritis, peritendinitis, and periostitis in the joints of the extremities and tail. Accompanying the arthritis in some cases, and never observed in its absence, are other specific tissue lesions including iridocyclitis, nodular lesions in the glabrous skin (ear, genitalia, feet, tail), transient rashes, a chronic skin disease, genitourinary lesions, and diarrhea. These make up a striking and characteristic picture. The arthritis usually precedes the other lesions and, together with the skin disease may show a prolonged and fluctuating course. Visceral lesions do not occur. Histologically, the basic lesion is a lymphocytic and histiocytic infiltration, initially perivascular and subsequently more disseminated. In addition, in the region of the joints and in the corpora cavernosa of the penis, there is extensive proliferation of mesenchymal cells, especially fibroblasts. Foci of fibrinoid necrosis are seen in the articular and nodular lesions, and destructive lesions of the joints are common. Such a combination of tissue lesions has not previously been described in experimental pathology. The experimental disease is shown to have both similarities to and differences from Reiter's syndrome, rheumatoid arthritis, and certain other disorders which occur in man.

Adjuvants, Immunologic↗

PubMed1961