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Biomedical subjects

J T Scott

Publications and source records attributed to J T Scott.

At least 19 recordsLinked to original sources
PubMed1992

Diuretic induced gout: a multifactorial condition.

Fifteen patients with clinical gout occurring after long term treatment with diuretics were studied retrospectively. In all 15 patients one or more additional factors were present which might have contributed to the hyperuricaemia and gout. The most common of these was the impairment of the glomerular filtration rate. Twenty five other patients receiving long term treatment with diuretics who did not have gout were also studied. The concentrations of uric acid, urea, and creatinine were, in general, markedly lower in these patients than in those who had developed gout. It is concluded that diuretic induced gout occurs in patients in whom there is an additional cause of hyperuricaemia, usually impaired renal function.

Aged↗
PubMed1991

Drug-induced gout.

A number of pharmacological agents can induce hyperuricaemia, and sometimes gout, usually by interfering with the renal tubular excretion of urate but also in some instances by increasing the formation of uric acid. Alcohol is well known to have this property and in recent years diuretic-induced hyperuricaemia has become a global phenomenon. Other drugs which can cause hyperuricaemia are salicylates, pyrazinamide, ethambutol, nicotinic acid, cyclosporin, 2-ethylamino-1,3,4-thiadiazole, fructose and cytotoxic agents. A special type of 'drug-induced gout' can follow the rapid lowering of serum uric acid by allopurinol or uricosuric drugs.

Cyclosporins↗
PubMed1990

Antinuclear antibodies and the diagnosis of systemic lupus erythematosus in patients with acute intermittent porphyria.

To investigate the previously postulated association of systemic lupus erythematosus (SLE) and porphyria 38 patients with various types of porphyria were investigated for clinical and laboratory evidence of a connective tissue disease. Antinuclear antibodies (ANAs) were found in 8/15 (53%) patients with acute intermittent porphyria. These patients were more likely to have had a recent acute attack of porphyria, but only one patient had clinical evidence of SLE. Antinuclear antibodies were not found in any patients with latent acute intermittent porphyria or appreciably in any of the other types of porphyria studied. This finding of ANAs in patients with acute intermittent porphyria may explain the previously described association with SLE. Strict diagnostic criteria need to be used in any one patient as these two disorders have many similar clinical manifestations.

Adult↗
PubMed1989

Alcohol and gout.

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Alcohol Drinking↗
PubMed1989

Systemic lupus erythematosus and acute intermittent porphyria.

A patient with systemic lupus erythematosus who subsequently developed attacks of acute intermittent porphyria is described. This case illustrates both the problems involved in the diagnosis and management of two disorders which share several clinical manifestations, and the influence of a connective tissue disease and its treatment on the expression of acute porphyria. The inter-relationship between these disorders and their possible association is discussed.

Acute Disease↗
PubMed1989

Chronic synovitis of the shoulder in familial Mediterranean fever: a disease of symptoms not signs.

Severe shoulder pain in a 41 year old Arab woman persisted for three months despite non-steroidal anti-inflammatory drug treatment. Isotope bone scanning and computed tomography showed inflammation of the glenohumeral joint and a large effusion, which needle aspiration had initially failed to reveal. A diagnosis of familial Mediterranean fever was made on the basis of a strongly suggestive past personal and family history, sterility of the joint effusion, and a good response to colchicine.

Adult↗
PubMed1989

Intermittent control of hyperuricemia in the treatment of gout.

Fifty patients with gout were randomly allocated to one of 2 groups receiving allopurinol, either continuously or for 2 months every year. Patients with renal functional impairment or tophacous gout were excluded. Duration of treatment ranged from 2-4 years. Acute gouty arthritis occurred to a similar degree in the 2 groups during the first year, but thereafter attacks occurred with diminishing frequency in the continuous group compared with the intermittent group. We concluded that the intermittent administration of allopurinol as given here is less effective in controlling symptoms of gout than continuous therapy.

Allopurinol↗
PubMed1987

Gout.

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Arthritis↗
PubMed1979

Yersinia arthritis.

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Arthritis, Infectious↗