The effects of aspirin on delayed hypersensitivity were assessed in 40 healthy subjects who were randomly assigned to two equal groups. In a double-blind format, the individuals in one group were placed on 4 gm aspirin daily for 5 days, and individuals in the other group were given placebo. Lymphocyte proliferation was measured before and 72 hours after the initiation of drug, by using three mitogens and four antigens. The percentages of T and B lymphocytes were likewise measured before and during therapy. The subjects were skin tested with the same four antigens 72 hours after the initiation of drug, and the skin tests were read 48 hours later. No significant differences between the two groups were detected when skin tests, lymphocyte proliferation, and percentage of T lymphocytes were compared.

Adult↗

PubMedDate not supplied

Comparison of two dosage schedules of gold salts in the treatment of rheumatoid arthritis. Relationship of serum gold levels to therapeutic response.

Two doses of gold sodium thiomalate were compared for their effect on rheumatoid arthritis. Thirty-seven patients with active disease for longer than 6 months were treated with 25 mg of gold sodium thiomalate for an average of 29.6 weeks, then at biweekly or monthly intervals to complete 2 years of treatment. Thirty-eight patients were given more than twice as much gold salt at the same intervals on a flexible dose schedule that produced serum gold levels which averaged 332 microgram/dl during the weekly injection phase. No differences were observed in the therapeutic responses of the two groups. Therefore the minimal dose of gold sodium thiomalate required to induce a response in rheumatoid arthritis is 25 mg or less per week. Serum gold levels in the steady state varied between 95 and 386 microgram/dl and were not related to response. Serum half-life for gold was calculated for patients who had an excellent response and for those who were treatment failures. The rate at which gold disappeared from serum was not related to therapeutic responses.

Adolescent↗

PubMedDate not supplied

Incremental threshold loading in patients with chronic obstructive pulmonary disease.

The purpose of this research was to study the reproducibility of incremental threshold loading, a test of inspiratory muscle endurance, in patients with mild to severe chronic obstructive pulmonary disease. Twenty-seven patients completed four weekly visits. A significant difference was noted between the first visit and subsequent visits for the maximum absolute load that patients could tolerate, but no difference was noted in the load relative to inspiratory strength. Breathing pattern did not change significantly among visits to account for the differences in absolute load. Patients had a tendency to use rapid shallow breathing at the end of the test, suggesting that they approached the limits of their endurance and thus nearly fatigued their inspiratory muscles.

Aged↗

PubMedDate not supplied

The effect of glucocorticosteroids on antigen-induced leukocyte migration inhibition.

Explore the source record for details and available documents.

Cell Migration Inhibition↗

PubMedDate not supplied

The etiology of rheumatoid arthritis.

Explore the source record for details and available documents.

Arthritis, Infectious↗

PubMedDate not supplied

Use and acceptance of ventolin Rotacaps and the Rotahaler in 1235 asthmatic patients.

This open-label study was performed to characterize the acceptance, reliability, and adverse event profile of a dry powder delivery system for albuterol. A total of 1235 asthmatic outpatients, aged 11 to 84 years, were studied for 1 month. Each patient enrolled was documented as having a specific complaint concerning the use of a standard metered-dose inhaler. At the end of 4 weeks of treatment, the patients completed a questionnaire to record their opinions and preferences. The results were as follows: 93% stated that Rotacaps were easy to use; 92% that they could use Rotacaps during an asthma attack; 99% that they had no problems with breakage of the device; 94% that the drug tasted pleasant or had no taste; 70% that they could inhale a full dose with one breath; and 79% that Rotacaps were at least as effective as the metered-dose inhaler they had used previously. Drug-related adverse events were reported by 6% of the patients; no single event was reported by more than 1% of the patients. The results indicate that Rotacaps are a safe, effective, and well-accepted alternative to metered-dose inhalers in asthmatic patients.

Administration, Inhalation↗