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Biomedical subjects

J T Shelton

Publications and source records attributed to J T Shelton.

7 recordsLinked to original sources
PubMed2001

Subcutaneous emphysema after restorative dental treatment.

Subcutaneous emphysema is an uncommon phenomenon in dentistry, usually occurring with the use of air-driven, high-speed handpieces during dental and oral surgery, operative, endodontic, or periodontal treatment. Air is forced into a surgical wound or subepithelial laceration in the oral cavity, dissecting through the different layers of tissue fasciae, and usually creating a unilateral enlargement of the facial and/or submandibular regions. This occurs with or without crepitus, pain, and airway obstruction. Treatment usually consists of antibiotic and mild analgesic therapy, close observation, and reassurance by the attending dentist. Symptoms generally subside in 3 to 10 days; however, consultation with a physician is necessary to rule out further complications.

Administration, Oral↗
PubMed1998

A mixture experiment approach for controlling the dissolution rate of a sustained-release tablet.

Several sustained-release tablet formulations with acceptable pharmacokinetic properties were found to be unstable because of the effects of lactose. Because the pharmacokinetic properties were acceptable, an attempt was made at developing stable formulations that reproduced the in vitro drug release characteristics of the unstable formulations. Through the use of a statistically designed mixture experiment, alternative formulations were generated and tested for dissolution. The dissolution data collected in the mixture experiment were used to develop a statistical regression model for identifying formulations with dissolution rates equal to those of the unstable formulations. The form of the regression model was based on the Higuchi equation. The data analysis indicated that it is possible to generate dissolution profiles that reproduce those of the original formulations by adjusting the ratios of Methocel K4MCR Premium and Methocel K100MCR Premium and by replacing the detrimental lactose with calcium phosphate dibasic anhydrous.

Calcium Phosphates↗
PubMed1997

Compound odontoma associated with an impacted permanent central incisor.

In this case report, an eleven-year-old female presented to a rural dental clinic for routine dental examination. Upon evaluation of the dentition, the attending dentist discovered an over-retained primary tooth. Radiographically, a compound odontoma was present, gingival to an unerupted permanent maxillary left central incisor (number nine) and apical to the erupted primary central incisor (F). The odontoma and its overlying primary tooth were removed by an oral surgeon. The extraction site has healed uneventfully and an Orthodontic treatment plan was formulated. The etiology of odontomas is unknown but thought to be caused by trauma, infection, inheritance and/or genetic mutation. These lesions are usually found in the second decade of life and are more common in male patients. Treatment consists of complete enucleation and curettage of the odontoma site.

Child↗