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Biomedical subjects

J T Snow

Publications and source records attributed to J T Snow.

13 recordsLinked to original sources

Golf science research at the beginning of the twenty-first century.

At the beginning of the twenty-first century, there are 30,000 golf courses and 55 million people who play golf worldwide. In the USA alone, the value of golf club memberships sold in the 1990s was US dollar 3.2 billion. Underpinning this significant human activity is a wide variety of people researching and applying science to sustain and develop the game. The 11 golf science disciplines recognized by the World Scientific Congress of Golf have reported 311 papers at four world congresses since 1990. Additionally, scientific papers have been published in discipline-specific peer-reviewed journals, research has been sponsored by the two governing bodies of golf, the Royal and Ancient Golf Club of St. Andrews and the United States Golf Association, and confidential research is undertaken by commercial companies, especially equipment manufacturers. This paper reviews much of this human endeavour and points the way forward for future research into golf.

Biomedical Research↗

Disordered eating in South-western Pueblo Indians and Hispanics.

The present study investigated the incidence of eating disorders in two samples representing populations seldom reported upon in the eating disorder literature: Pueblo Indians and Hispanics. Subjects were 95 students from a rural, public high school serving primarily low income families. Although no ethnic differences were found, the majority of girls in both samples reported wanting to lose weight, being worried about their weight, and indulging in binge eating. Nine of the girls (11 per cent) reported eating habits consistent with the DMS III (APA, 1980) criteria for bulimia. In contrast, few boys indicated concerns about their weight or eating habits. The results suggest that eating disorders and concern about obesity are found in a variety of ethnic groups in the United States today.

Adolescent↗

High resolution gas chromatographic analysis of nonpolar chlorinated hydrocarbons in human milk.

A gas chromatographic method is described for the analysis of human milk to determine polychlorinated biphenyls (PCBs) as 72 congeners plus p,p'-DDE, mirex, hexachlorobenzene, and octachlorostyrene. The detection limit for individual compounds is about 0.05 ng/g when 30 g milk is analyzed. Total PCBs can be estimated with a detection limit of 1-5 ng/mL milk. Analytical precision is better than +/- 10% for all compounds at 20-50 ng/mL whole milk.

Chromatography, Gas↗

Inhibitory effect of mercaptoamino acids on lysino-alanine formation during alkali treatment of proteins.

Alkali treatment of food proteins converts some amino acid residues to the unnatural amino acid lysinoalanine which has been found to cause kidney damage when fed to rats. Formation of lysinoalanine was essentially prevented when isolates of soy protein and casein were exposed to alkali in the presence of thio-alamino acids such as cysteine. The results suggest that added thiols minimize the formation of potentially toxic lysinoalanine.

Alanine↗

Value of prophylactic peripheral iridectomy on the second eye in angle-closure glaucoma.

In a group of 250 patients with gonioscopically proved angle-closure glaucoma, 72 who did not have prophylactic peripheral iridectomy were reviewed and the adverse effects suffered by these patients were analysed. Comparison was made with 63 patients from the same group who did have peripheral iridectomy. All these patients were drawn from the Glaucoma Clinic, University Department of Ophthalmology, Manchester Royal Eye Hospital.

Adult↗

Relative reactivities of sulfhydryl groups with N-acetyl dehydroalanine and N-acetyl dehydroalanine methyl ester.

The reaction rates in aqueous solutions of aminothiols, thiols, and other compounds with N-acetyl dehydroalanine and its methyl ester (2-acetamindoacrylic acid and methyl 2-acetamidoacrylate) were studied as a function of the structure of the thiol compound in aqueous solutions. Correction of the observed second-order rate constants to identical thiol anion concentration gave a series of computed rate constants whose logarithms showed a linear dependence on the pK's of the thiol group in similar steric environments. Comparison of the addition rates of penicillamine to N-acetyl dehydroalanine and its methyl ester showed the methyl ester to react approximately 11,400 times faster than the acid. Addition rates for thiol acids and aromatic and heterocyclic thiols were also compared; each showed sluggish reactivity with dehydroalanine, but each reacted readily with methyl dehydroalanine. The kinetic data were applied in developing a method for preparing lanthionine in high yield.

Alanine↗

A kinetic study of the hydrolysis of N-acetyl dehydroalanine methyl ester.

Hydrolysis rates of N-acetyl dehydroalanine methyl ester (methyl 2-acetamidoacrylate) and related model compounds were measured in aqueous, organic and mixed aqueous media. Adding dimethylsulfoxide (DMSO) to water, retarded hydrolysis of the ester by a factor of 2 to 500, depending on the pH of the medium and concentration of DMSO. Ethanol also slowed hydrolysis, but the effect was not so pronounced. Related studies show that the acetamido group C-N bond of sodium 2-acetamido-acrylate is hydrolyzed only about 1/130 as fast as the ester group C-O bond. Aqueous dimethyl sulfoxide should by a useful medium for synthesis of peptide, amino acid and protein derivatives of N-acetyl dehydroalanine methyl ester.

Acrylates↗