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Biomedical subjects

J T Turkka

Publications and source records attributed to J T Turkka.

6 recordsLinked to original sources
PubMed1987

Sweating dysfunction in Parkinson's disease.

Sweating was measured with an evaporimeter in 5 different positions on both sides of the body in 23 patients with idiopathic Parkinson's disease and in 11 age-matched control subjects before and after a heating stimulus. Perspiration was increased significantly both before and after the heating provocation in the upper part of the body (the forehead, chest and forearm) of Parkinson patients in comparison with the control subjects (p less than 0.05). The increase of perspiration correlated significantly (p less than 0.05) with the severity of Parkinson's disease as estimated by the Webster scale. The results indicate wide and clear autonomic nervous system dysfunction in Parkinson's disease.

Aged↗
PubMed1987

Correlation of autonomic dysfunction to CSF concentrations of noradrenaline and 3-methoxy-4-hydroxyphenylglycol in Parkinson's disease.

In order to study the role of the neurotransmitter noradrenaline (NA) and its main brain metabolite 3-methoxy-4-hydroxyphenylglycol (MHPG) in autonomic failure in Parkinson's disease (PD), an analysis of the relation of cerebrospinal fluid (CSF) NA and MHPG levels and a rating of autonomic nervous system (ANS) impairment was carried out. The mean baseline NA level in CSF of PD patients was 220.0 +/- 110.0 pg/ml, and the mean baseline MHPG level 9.9 +/- 3.9 ng/ml. These levels did not differ from those of age-matched controls. Within the group of patients with PD neither the duration of the disease nor its medication influenced the results. No correlation could be found in patients with PD between the CSF NA levels and the severity of autonomic failure, but a clear correlation was found between the CSF MHPG concentrations and the severity of autonomic failure.

Aged↗
PubMed1987

Cardiovascular reflexes in Parkinson's disease.

The autonomic nervous system (ANS) function of patients with Parkinson's disease (PD) was investigated in 30 patients with PD, and in 21 healthy subjects of similar age by utilizing cardiovascular reflex measurements as indicators. In deep breathing, in the Valsalva manoeuvre, and in the tilting test the heart rate variability (R-R variation) differed significantly between the patients and the controls: the beat-to-beat variation was clearly decreased in patients with PD. Responses in diastolic pressure to isometric work were also clearly diminished. However, no significant differences in any measured ANS indices were found between the patients who were treated with levodopa and those who were not. Similarly, anticholinergics did not seem to affect the results.

Adult↗
PubMed1987

Correlation of the severity of autonomic dysfunction to cardiovascular reflexes and to plasma noradrenaline levels in Parkinson's disease.

The present study analyses the relation of both the diminished cardiovascular reflexes and the diminished plasma noradrenaline (NA) response to standing to the severity of the autonomic nervous system (ANS) dysfunction in patients with Parkinson's disease (PD). 47 patients with PD were investigated. A clear correlation was established between the duration and the severity of PD (by the Webster rating scale) and the degree of autonomic dysfunction (ANS disability scale). Similarly, a significant negative correlation was found between the diminished cardiovascular reflexes and the clinical severity of the ANS disturbance. Furthermore, a slight correlation was shown between the clinical severity of ANS dysfunction and plasma NA concentrations in response to a standing-up stimulus.

Aged↗
PubMed1986

Serum noradrenaline response to standing up in patients with Parkinson's disease.

Responses of serum noradrenaline (NA) levels to standing up were determined in patients with Parkinson's disease (PD) examining 15 patients and 13 healthy subjects of similar age in order to obtain information about autonomic failure in PD. Mild symptoms of autonomic dysfunction were found in all the patients. The mean (+/- SD) increment of serum NA levels as a response to standing up of patients was 0.11 +/- 0.29 nmol/l and that of the controls 1.09 +/- 1.15, the percentage rises being 5.4 +/- 12.1 and 38.2 +/- 35.0, respectively. These results indicate that serum NA responses to standing up in patients with PD are significantly diminished describing a sympathetic nervous system deficit in PD.

Adult↗