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J T Wegner

Publications and source records attributed to J T Wegner.

11 recordsLinked to original sources
PubMed1986

Outcome study of first-episode psychosis. I: Relapse rates after 1 year.

One-year relapse rates were assessed in a group of 64 patients diagnosed by Research Diagnostic Criteria who were hospitalized for their first psychotic episode. Life-table analysis showed that of the 51 remitted patients, 71.4% of the schizophrenic patients (N = 20), 71.4% of patients with affective disorders (N = 10), and 77.8% of patients diagnosed as having either unspecified functional psychosis or other psychiatric disorder (N = 7) remained in remission at 1-year follow-up. Factors associated with relapse or poor outcome (patients who remained in episode) included no maintenance medication, longer duration of illness, and premorbid asociality.

Adult↗
PubMed1985

Schizophrenics with tardive dyskinesia. Neuropsychological deficit and family psychopathology.

We investigated the role neurologic soft signs, premorbid asociality, psychometric tests, and family history of psychiatric illness may play in the identification of patients at risk for tardive dyskinesia (TD) development. Thirty-two TD and 32 non-TD schizophrenics served as subjects. The results indicated that patients with TD have more soft signs, are more frequently rated as poor premorbid asocials, perform more poorly on psychometric testing, and have a familial loading for affective disorders in first-degree relatives higher than control patients. A discriminant function analysis correctly classified 84.4% of the patients into their respective groups. Subtle yet quantifiable differences exist between TD and non-TD patients and these deficits may render the individual more vulnerable to TD development.

Adult↗
PubMed1985

The Cognitive Deficit subscale of the SCL-90-R and prediction of outcome in first episode schizophrenics.

This study examined the relationship between the Cognitive Deficit scale and psychiatric outcome in a sample of 31 first episode schizophrenics. These patients initially were evaluated during their inpatient hospitalization and thereafter assessed for psychiatric symptomatology at 3-, 6-, and 12-month intervals. At the end of 12 months, 51.6% of the sample were in remission, and 48.4% either remained in their psychotic episode during the follow-up period or relapsed. However, the two Cognitive Deficit scores obtained at baseline showed no relationship with subsequent outcome of psychiatric illness. It is suggested that this scale may not be sensitive enough to be used as a diagnostic tool with this group of patients.

Adult↗
PubMed1985

Cognitive impairment in tardive dyskinesia.

Psychiatric patients in a prospective study on tardive dyskinesia (TD) development were psychometrically evaluated before TD onset to see whether cognitive impairment predisposes an individual to greater risk for TD. It was found that patients with TD showed more preexisting cognitive impairment than did the non-TD controls.

Adult↗
PubMed1981

Familial occurrence of tardive dyskinesia.

Tardive dyskinesia remains a poorly understood consequence of neuroleptic treatment for psychiatric illness. To date, there have been no reports in the literature regarding the presence of dyskinetic symptomatology in first degree relatives or other family members. The following two cases reveal the development of abnormal involuntary movement in brothers with similar mental illness and treatment histories, and suggest the importance of examining neuroleptically treated relatives of an affected individual for dyskinesia and may suggest a genetic factor in vulnerability.

Adult↗
PubMed1979

Relationship between the B-mitten EEG pattern and tardive dyskinesia. A pilot control study.

The identification of patients at high risk for the development of tardive dyskinesia (TD) is a major problem in psychopharmacology. We found a possible relationship between the subcortical B-mitten EEG pattern and TD. Twenty-one TD pateints were matched on a number of relevant variables with 21 patients without TD. Ninety-five percent of the TD patients had mittens, compared to 33.3% of controls. The results suggest that the mitten dysrhythmia may be a risk factor for the development of TD. Additional findings suggest that among TD patients, mittens are differentially more frequent in younger (93.1%) as opposed to older (0.0%) subjects.

Adolescent↗
PubMed1977

Incidence of the 14 and 6 per second positive spike pattern in an adult clinical population: an empirical note.

Although 14 and 6 per second positive spiking in children and adolescents has received extensive investigative attention resulting in conflicting results and opinion, efforts to study this finding in adult populations have been almost totally neglected. The present study attempts to contrast the incidence of this EEG finding in an adult clinical psychiatric sample with similar incidence data derived froma historical normal adult control series. From 10 years of laboratory data, the presence or absence of positive spikes was noted in the waking and sleep EEGs of 2888 psychiatric patients aged 20 and above. These incidence figures were contrasted with similar data derived from the EEG'S of 619 normal adults of similar age collected in a previously published control series. A differentially higher incidence of positive spiking in the adult clinical population as contrasted with the adult normal control population occurred with a high level of statistical significance. Methodological and technological aspects of electroencephalographic recording for the current clinical group and the historical control population are felt to be virtually identical and the possible effect of differential recording or interpretive practice confounding the present results does not seem plausible. The present results offer no solution or resolution of the positive spike controversy. They do, however, suggest that additional focus on this EEG signal in adults may possibly have merit.

Adult↗