Thyroid hormones in patients with chronic renal failure undergoing maintenance hemodialysis.
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Biomedical subjects
Publications and source records attributed to J Talbot.
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Precision obtained with two different serum pools used daily as internal quality-control specimens by 130 laboratories throughout Canada (Canadian Interlab Program) is reported for 14 analytes assayed by either manual or automated methods over a period of 16 months. Precision criteria set by Barnett to meet medical needs were not met for calcium, glucose, phosphorus, and urea nitrogen by more than 10% of the laboratories studied. Specific guidelines for laboratory precision are suggested for optimal and minimal performance in the assays of albumin, bilirubin, calcium, chloride, cholesterol, creatinine, glucose, phosphorus, potassium, sodium, total protein, triglyceride, urea nitrogen, and uric acid.
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A total of 134 cases of retinal detachment treated with a single successful nondrainage operation were studied to assess the rate of absorption of subretinal fluid in the postoperative period. It has been found that the relationship of the tear to the buckle at the end of the operation is an indicator of the rate of absorption of subretinal fluid that can be expected in the postoperative period. The age of the detachment or the age of the patient did not appear to be significant factors in influencing absorption. In 28 cases (21%), absorption of subretinal fluid took longer than one week. This delay in absorption shows that conservatism regarding early reoperation should be urged unless a definite cause of failure (such as a missed tear) can be found.
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Various biochemical markers of cancer were investigated in two men aged 26 and 45 years with primary mediastinal choriocarcinoma. The daily excretion of urinary human chorionic gonadotropin (HCG) and the serum concentration of the beta-subunit of HCG were elevated in both patients, but carcinoembryonic antigen, Regan isoenzyme, alpha1-fetoprotein, serum pregnancy-associated globulin and human chorionic somatomammotropin were not detectable. Comparison of the results of the investigation of biochemical markers of this rare neoplasm in these two men with those published previously illustrates the discordance in the expression of biochemical markers of primary mediastinal choriocarcinoma.
A survey of serum albumin determinations in a group of patients with renal failure revealed that albumin reasurements using the 2-(4'-hydroxyphenylazo)-benzoic acid (HABA) dye-binding method were understimated when compared to results obtained with the biuret method. Equilibrium dialysis of the HABA dye binding to albumin are reported. Scatchard plot analysis showed that an average of 5.7 binding sits per molecule of albumin were unavailable in renal failure patients. The binding interference encountered in these patients indicates that alubumin measurements using dye binding techniques should not be used for these patients.
Renin studies were done on 2 patients with adenocarcinoma of the kidney and hypertension. In 1 case plasma renin activity was high in the peripheral and renal veins, with a renal vein ratio of 1.7 favoring the side of the tumor. Nephrectomy cured the hypertension and renin values became normal. Tissue renin was elevated in the tumor and surrounding parenchyma. Acidification studies of tissue extracts failed to demonstrate the existence of big renin. In case 2 all renin values were normal and the blood pressure remained elevated after the operation. Although renin-secreting tumors remain an uncommon cause of malignant hypertension the condition should be recognized because it is potentially curable.
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