PubMed Health⌕ Search

Biomedical subjects

J Tanaka

Publications and source records attributed to J Tanaka.

At least 631 records · Page 35Linked to original sources
PubMed1989

Electrocardiogram studies on cancer patients treated with OK-432, a streptococcal preparation with potent biological response modifier activities.

The present study was performed to see if OK-432, a useful anticancer agent with potent biological response modifier activities, induces effects on heart due to its nature as a streptococcal preparation. Examination of electrocardiograms of cancer patients treated with a variety of doses and routes of OK-432 has revealed that none of 266 patients examined showed any significant change in electrocardiograms (ECGs) after OK-432 treatments, regardless of their pretreatment heart conditions (normal or abnormal ECGs). Furthermore, these patients did not develop any detectable antibodies against heart muscle, either in serum or deposited on heart tissue. Experimentally, antibodies reactive with human heart tissue became detectable in the sera of rabbits immunized with streptococci in complete Freund's adjuvant, confirming the previous reports. However, the repeated injections of OK-432 without the adjuvant did not induce any detectable antibodies. These results indicate that OK-432 can be used for treating cancer patients with little fear of possible side effects on the heart.

Adult↗
PubMed1989

[Two cases of primary pulmonary non-Hodgkin lymphoma].

Two cases of primary pulmonary non-Hodgkin lymphoma were presented. Case one had diffuse, homogeneous consolidation with air bronchogram in rt. upper lobe. Case two had a mass-like shadow with air bronchogram in rt. middle lobe. Both had no significant symptom, pleural effusion and lymphadenopathy. Patients with this entity had good prognosis.

Aged↗
PubMed1989

[Multidisciplinary treatment of head and neck cancer].

UNLABELLED: This presentation deals with multidisciplinary treatment of head and neck cancer, especially focusing on maxillary sinus carcinoma (MSC) and nasopharyngeal carcinoma (NPC). Since 1982, a new multidisciplinary treatment incorporating neo-adjuvant chemotherapy has been introduced in the treatment of MSC. The Neo-adjuvant chemotherapy includes cisplatin (CDDP) + peplomycin (PEP), adriamycin (ADR) analogs + CDDP + PEP, and CDDP +5-FU. Two courses of chemotherapy were given intraarterially with the interval of 2 weeks. Routinely, radiotherapy of 40 Gy by Linac was given to the primary tumor site, concomitantly combined with 5-FU intraarterial injections only during the first 10 days, 2 weeks after the end of chemotherapy. Additional treatment was performed according to the extent of the residual tumors. The 5-year survival rate for the 28 patients treated with this therapy was 55%. The 5-year survival rate by T classification was 100% for T2, 76% for T3 and 0% for T4 cases. The preservation rate of maxillo-facial structures and functions was 82%. Concerning NPC, neo-adjuvant chemotherapy included CDDP + PEP, ADR + CDDP + PEP and ADR + cyclophosphamide + PEP. Two courses of chemotherapy were performed, followed by radiotherapy of 60 Gy by Linac. Then intracavitary 60Co therapy was performed, followed by adjuvant chemoimmunotherapy. The 5-year survival rate for 21 patients treated with this therapy was 44%. CONCLUSIONS: (1) The 5-year survival rate was better for patients with MSC who were treated with multidisciplinary treatment incorporating intraarterial neo-adjuvant chemotherapy than that for patients who received other treatment so far. Furthermore, the highest preservation rate of maxillo-facial structures and functions was achieved in the neo-adjuvant chemotherapy group. However, survival rates for T4 cases were very poor, so another approach should be taken. (2) The 5-year survival rate was also better for patients with NPC who were given multidisciplinary treatment than for patients who received other treatment to date. However, there was no decrease of distant metastases, which we aimed initially, despite the introduction of neo-adjuvant chemotherapy.

Adult↗
PubMed1989

[Developmental changes in electrically elicited blink reflex in infancy and childhood].

Developmental changes in electrically elicited blink reflex (BR) in 118 normal subjects, aged from 32 weeks of conceptional age to 14 years of age. During the waking state, R1 and bilateral R2 responses were always elicited. The latency of R1 shortened rapidly during the neonatal period, reaching the adult value at 3 months of age. The latency of R2 and contralateral R2 (CR2), which were elicited synchronously after 3 years of age, shortened slowly during childhood and reached the adult value at 6 years of age. The conduction indexes of R1, R2 and CR2, which were calculated as head circumference/latency (m/sec), increased rapidly during the neonatal period and reached the adult values at 6 years of age. The influence of NREM sleep on BR in neonates was different from those in infants and children. While BR of neonates in NREM sleep showed similar to that seen in wakefulness, BR of infants and children after one month of age was suppressed during NREM sleep. BR pattern in NREM sleep in infants and children after 6 months of age was similar to that seen in adults.

Adult↗
PubMed1989

[Clinical assessment of prosthetic valve replacement of the right-sided cardiac valves: mechanical or bioprosthesis?].

Clinical results with mechanical and bioprosthetic valve replacements for tricuspid and/or pulmonary positions were reviewed. Between February 1975 and December 1985, 34 bioprostheses (B) (22 Hancock, 9 Ionescu-Shiley and 3 Carpentier-Edwards pericardial) and 18 mechanical prostheses (M) (St. Jude Medical) were implanted in our institute excluding hospital death. Group with B included 29 tricuspid valve replacements and 5 pulmonary valve replacements. Group with M included 9 tricuspid valve replacements, 7 pulmonary valve replacements and 1 both valve replacements. The cumulative follow-up period was 207.2 patient-years (p-t) in group B and 55.0 p-y in group M. The incidence of valve failure was 0.48 +/- 0.48% per p-y in group B and 7.27 +/- 3.64% per p-y in group M (p less than 0.001). The incidence of valve-related events was 1.93 +/- 0.97% per p-y in group B and 9.09 +/- 4.07% per p-y in group M (p less than 0.001). At 3 years, the percent free of valve failure was 100 +/- 0% in group B and 76.8 +/- 10.2% in group M (p less than 0.05). Fourteen bioprosthetic valves (B') and 10 mechanical valves (M') were implanted at the right-sided cardiac valve position alone. The cumulative follow-up period was 94.2 p-y in group B' and 32.3 p-y in group M'. The incidence of valve-related events was 1.06 +/- 1.06% per p-y in group B' and 12.4 +/- 6.19% per p-y in group M' (p less than 0.001).(ABSTRACT TRUNCATED AT 250 WORDS)

Adolescent↗
PubMed1989

Fatigue caused by visual display terminal work: an experimental investigation.

Experiments were carried out to examine fatigue during VDT work under circumstance in which the conditions of rest and work were combined. Four experimental conditions based on rest types and work content were designed as follows: 1, (input of interesting sentences) + (dynamic rest); 2, (input of interesting sentences) + (static rest); 3, (input of meaningless numbers) + (dynamic rest); and 4, (input of meaningless numbers) + (static rest). One operation unit was comprised of 50 min of VDT work and 15 min of rest. Subjects were assigned to three operation units in both the morning and afternoon. Flicker test, kinetic vision examination, inquiry into subjective symptoms, and test of single digit addition for 10 minutes according to Kraepelin's examination were conducted both before and after morning and afternoon operation sessions, for four times per day. Flicker test and kinetic vision examination were carried out immediately before and after each individual operation unit. Results obtained are shown as follows: 1) When input conditions were compared, e.g. sentence input vs. number input, there was no significant difference in the complaint rate of subjective symptoms, the amount of single digit addition or in Flicker test value. The decrease in kinetic vision levels after each afternoon operation in the sentence input group was slightly smaller than that in the number input group. 2) When rest conditions were compared, there was no difference in the results of total input, Flicker test value and amount of single digit addition between dynamic rest and static rest.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMed1989

[Removal of an intracardiac foreign body].

Four patients with intracardiac foreign body, in whom central venous catheter was accidentally cut and its fragment was migrated into the cardiovascular system, are presented. One patient was surgically treated. Other patients were treated using transvascular catheter technique. In one of three patients, however, a chorda of tricuspid valve was hooked by a grasping catheter and the patient was forced to surgical removal of both a catheter fragment and the grasping catheter. We discussed the method and problems to remove intra-cardiovascular foreign body.

Aged↗
PubMed1989

[Surgical aspect of active infective endocarditis].

Twenty patients with active infective endocarditis, 11 with native valve endocarditis (NVE) and 9 with prosthetic valve endocarditis (PVE), were treated surgically from 1975 through April 1987 at Kyushu University Hospital. The operative indications were congestive heart failure mainly due to massive aortic regurgitation in 18, periannular abscess in 6, major embolism in 5 and severe hemolysis in 3 patients. In the group of NVE, single aortic valve replacement was performed in 4 patients and multiple valve replacement in the remainder. One patient died early postoperatively from LOS. Two patients with recurrent infective endocarditis, which occurred within 60 days after previous prosthetic valve replacement, were operated subsequently as early PVE. All other patients became NYHA class I postoperatively except for one patient who died from thrombosed valve. In the group PVE, re-AVR was done in 3, re-MVR in five, double valve replacement in two and re-fixation of the prosthesis to the aortic annulus in one patient. Two patients with early PVE died from recurrent endocarditis late postoperatively. One of 7 patients with late PVE, who had suffered from myocardial and cerebral infarction before reoperation, died from multiple organ failure. There were 3 patients with perivalvular leakage due to late active PVE, whose preoperative signs of inflammation were negative or minimum. As recurrent perivalvular leakage due to persistent infective endocarditis might frequently occur in such cases, complete resection and debridement of infected foci should be emphasized.

Adolescent↗
PubMed1988

Involvement of the septum in the regulation of paraventricular vasopressin neurons by the subfornical organ in the rat.

Extracellular recordings were obtained from 58 phasically active neurosecretory neurons in the hypothalamic paraventricular nucleus (PVN) of urethane-anesthetized male rats. Of these PVN neurons, 39 exhibited an increase and 11 displayed a reduction in ongoing activity following electrical stimulation of the subfornical organ (SFO), while the remaining neurons were unresponsive. Microinjection of the local anesthetic lidocaine into the medial septum reversibly abolished the SFO stimulus-evoked reduction in 7 out of 9 PVN neurons tested, whereas similar injection was without effect on the stimulus-evoked increase in 18 out of 20 PVN neurons tested. These results suggest that the SFO efferents through the medial septum to the PVN exert a predominantly inhibitory influence on the excitability of putative vasopressin (VP)-secreting neurons in the PVN.

Action Potentials↗
PubMed1988

The median preoptic nucleus participates in the control of paraventricular vasopressin neurons by the subfornical organ in the rat.

Extracellular single-unit activity was recorded from phasically firing neurohypophyseal neurons (n = 41) in the hypothalamic paraventricular nucleus (PVN) of urethane-anesthetized male rats. Electrical stimulation of the subfornical organ (SFO) produced orthodromic long-duration (n = 18) or short-duration (n = 10) excitation or inhibition (n = 8) of the activity of PVN neurons. The long-duration excitatory response of about half (n = 7) the neurons (n = 15) tested was reversibly abolished by microinjection of the local anesthetic lidocaine into the median preoptic nucleus (MnPO), whereas neither the short-duration excitatory (n = 7) nor inhibitory (n = 6) responses were affected. These results suggest that the SFO efferents through the MnPO to the PVN may transmit the neuromodulatory signals which evoke long-duration increases in the excitability of putative vasopressin (VP)-secreting neurons in the PVN.

Action Potentials↗
PubMed1988

Neurons in the lateral hypothalamic area and zona incerta with ascending projections to the subfornical organ area in the rat.

Sixteen neurons in the lateral hypothalamic area (LH) and 12 neurons in the zona incerta (ZI) were antidromically activated by electrical stimulation of the subfornical organ (SFO) area in urethane-anesthetized male rats. The activity of these LH and ZI units was examined for response to intracarotid injections of isotonic (0.15 M NaCl solution, 0.05 ml) or hypertonic (0.18 M or 0.3 M NaCl solution, 0.05 ml) saline. All the units did not change their activity to the injections of isotonic saline. Of these units, 9 LH and 5 ZI units displayed an increase and 2 LH and 3 ZI units exhibited a reduction in neuronal activity following the injections of hypertonic saline, while the remaining 5 LH and 3 ZI units were unresponsive. The present results suggest that the LH and ZI neurons with ascending projections to the SFO may carry the information from osmoreceptive elements for modulating the actions of the SFO.

Afferent Pathways↗
PubMed1988

Neurons in the nucleus of the solitary tract with ascending projections to the subfornical organ in the rat.

Thirty-one neurons in the region of the nucleus of the solitary tract (NTS) were antidromically activated by electrical stimulation of the subfornical organ (SFO) in male rats under urethane anesthesia. The activity of these identified neurons was tested for a response to activation of peripheral baroreceptors, achieved by rising arterial blood pressure with an intravenous administration of the alpha-agonist metaraminol. Of the neurons tested, 17 displayed an increase and 6 exhibited a reduction in neuronal firing that accompanied a 40- to 60-mmHg elevation in mean arterial pressure, while 8 were unresponsive. The results suggest that neurons projecting to the SFO in the region of the NTS may be important for carrying peripheral baroreceptor information to the SFO.

Action Potentials↗
PubMed1988

Neuropathological study on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine of the crab-eating monkey.

Experimental parkinsonism was induced by systemic administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) to the crab-eating monkey (Macaca fascicularis). In the acute stage, the substantia nigra showed necrotic nerve cells, extracellular release of pigment granules and histiocytic infiltration. The nerve cells underwent vacuolation of the cytoplasm with chromatin clumping of the nucleus and disintegration of the nucleolus. The striking feature was the presence of variously-shaped inclusion bodies within abnormal mitochondria which sometimes disclosed a distortion of the cristae. Golgi apparatus and endoplasmic reticulum were also dilated. In the locus ceruleus swollen nerve cells were observed with vacuolated cytoplasm and pyknotic nucleus where expanded mitochondria also contained the inclusions. Some of the inclusion bodies are probably insoluble precipitations due to inhibition of mitochondrial oxidation by a certain metabolite of MPTP. In the protracted stage the substantia nigra revealed a considerable loss of the nerve cells associated with melanophagia and astrocytic proliferation. A few surviving nerve cells showed an increased number of Golgi apparatus and rough endoplasmic reticula, and the presence of autophagosomes, dense bodies and intra-mitochondrial inclusion. These changes are interpreted as being a part of the reparative process from the cellular damage.

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine↗
PubMed1988

Inability of translation of mRNA for HVJ (Sendai virus) M protein in a rat glioma cell line at nonpermissive temperatures.

The synthesis of M protein of HVJ (Sendai virus) in rat glioma (C6) cells, as has previously been reported, is selectively reduced at a nonpermissive temperature of 39 degrees C. In this phenomenon no difference was found in the viral RNA synthesis and the stability of the viral RNAs between the permissive and nonpermissive temperatures. Oligo dT-selected RNA from the infected cells at either temperature similarly directed M protein synthesis in cell-free translation reactions even if the reaction was performed at 39 degrees C. These results suggest that the restriction of M protein synthesis in C6 cells at the nonpermissive temperature might be due to the inability of translation apparatus to interact with the mRNA coding for M protein.

Animals↗
PubMed1988

Progressive vascular lesions in Williams-Beuren syndrome.

We report two patients with Williams-Beuren syndrome. The first patient showed no evidence of coarctation of the aorta at the first examination. Seven years later, she developed coarctation of the aorta. In the second patient, we found the progression of renal artery stenosis by serial angiography. We report that vascular lesions may be progressive in Williams-Beuren syndrome.

Adolescent↗
PubMed1988

Intraoperative pulmonary embolization by the tip of a Polystan venous return catheter.

In a 10-year-old girl being treated for ventricular septal defect, the tip of a Polystan venous return catheter broke away when the catheter was being removed at the time of bypass disconnection. Following fluoroscopic identification of the tip in the left peripheral pulmonary artery, it was removed via arteriotomy.

Catheterization, Central Venous↗