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Biomedical subjects

J Tatoń

Publications and source records attributed to J Tatoń.

At least 19 recordsLinked to original sources
PubMed1997

[Prospective studies of diabetic retinopathy in a cohort of patients with type II diabetes mellitus].

To gain current data about epidemiology of diabetic retinopathy in a population of type 2 diabetics a long-term prospective study was started. The study included 1334 patients with type 2 diabetes mellitus registered in Warsaw regional Diabetes Center. The prevalence of any form of diabetic retinopathy in this group was 31.4% and proliferative retinopathy-1.3%. It was found that the patients with retinopathy had diabetes mellitus of longer duration, higher fasting and postprandial levels of glycemia and higher daily proteinuria in comparison with diabetics without retinopathy. Apart from that, a frequency of ischemic heart disease and lower extremity ischemic disease was higher in diabetics with retinopathy. 109 new cases of retinopathy were diagnosed during 3-year follow-up. The study allowed us to determine the current epidemiological parameters concerning diabetic retinopathy in type 2 diabetics and a set of parameters characterizing people at highest risk of a development of retinopathy.

Aged↗
PubMed1997

[Microcirculatory evaluation of the early diabetic foot syndrome using laser doppler].

UNLABELLED: Recognition of early microcirculatory disturbances in feet of diabetics may facilitate the pathogenic interpretation of the diabetic foot syndrome, selection of the patients at risk of developing clinical problems and serve as the base for designing the preventive measures. This could be particularly true in diabetics with peripheral neuropathy. Therefore the study aimed at the assessment of functional parameters of the foot microcirculation in IDDM patients presenting signs of peripheral neuropathy but without any symptoms of the diabetic foot syndrome was undertaken. For comparison 20 IDDM subjects with the signs of peripheral neuropathy and 10 IDDM subjects without this complication were studied both clinically and metabolically. All of them underwent the examination of microcirculation of the feet with the use of Laser Doppler Flowmeter. The parameters measured were: resting blood flow, post-occlusive, hyperemic response, flow change after heating to 44 degrees C and the flow on dependency. In IDDM subjects with peripheral neuropathy the following functional microcirculatory abnormalities were found: delay and decrease in post-occlusive, hyperemic response (4.5 +/- 1.8 s in neuropathic vs 0.5 +/- 2.4 s in non-neuropathic IDDM patients), decrease of the peak flow (36 +/- 7.0 PU in non neuropathic vs 18 +/- 5.0 PU in neuropathic IDDM patients) and also impairment of the response of the skin flow to focal heating peak flow at 44 degrees C (48 +/- 7.0 PU vs 12 +/- 3.0 PU in non neuropathic IDDM patients). Also the venoarteriolar reflex measured as the ratio of resting to standing flow in the feet skin was significantly decreased (80% in non-neuropathic versus 35% in neuropathic IDDM patients). CONCLUSION: Laser Doppler Flowmetry discovers the very early functional abnormalities in the microcirculation of the skin in the feet of IDDM with peripheral neuropathy, when none of the typical symptoms of the diabetic foot syndrome is present. It points to the significance of the relation between neuropathic and microcirculatory disturbances in the early pathogenesis of diabetic foot syndrome.

Adult↗