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Biomedical subjects

J Terpstra

Publications and source records attributed to J Terpstra.

29 records · Page 2Linked to original sources
PubMed1975

The incidence of diabetes mellitus in the offspring of diabetic couples. Investigation based on the oral glucose tolerance test.

88 of 137 offspring of 22 adult onset diabetic couples were subjected to an oral glucose tolerance test (G.T.T.); 35 were found to have a diabetic G.T.T. As 8 were already known as diabetics, 43 of 96 offspring (45%) were found to have diabetes mellitus. Neither the data pertaining to the parents, such as family history, treatment of diabetes or obstetric history, nor the data pertaining to the offspring, such as sex, age, parity or course of pregnancy, could be related to the incidence of diabetes in the offspring. It was noted however, that overweight female, but not male, offspring are more likely to develop diabetes than those who are not overweight (p less than 0.05).

Adolescent↗
PubMed1975

The effect of phenformin-HCl on patients with diabetes mellitus, studied under strict balance conditions.

Under strict balance conditions we studied the effect of phenformin in 5 patients with diabetes mellitus. In all cases phenformin lowered the blood glucose values, and all patients showed a reduction of glycosuria. Contrary to other reports body weight increased during phenformin treatment. This was accompanied by positive nitrogen, phosphorus and calcium balances. The weight gain can be explained by the positive caloric balance, mainly caused by the diminished glycosuria. No change in B.M.R. or R.Q. was seen. During phenformin treatment there was a drop in cholesterol and total lipid levels in 4 patients. No conclusions could be drawn about the effect of phenformin on triglycerides, phospholipids and lipoprotein spectra. Phenformin treatment did not affect the disappearance of glucose, nor the insulin levels after intravenous glucose loading. During oral glucose loading phenformin caused a significant fall in blood glucose levels, accompanied by an increased insulin response in one patient. In the other 4 patients phenformin had no effect on either parameter.

Aged↗
PubMedDate not supplied

Natural history of nephropathy in type I diabetes. Relationship to metabolic control and blood pressure.

In recent years, the respective roles of metabolic control and blood pressure on the development of nephropathy in patients with type I diabetes have been studied intensively. Based on our own retrospective analysis, we conclude that metabolic control, but not blood pressure, determines the onset of proteinuria in these patients. Once proteinuria has developed, concurrent metabolic control has little effect on the time interval to onset of renal failure. In contrast, blood pressure has great predictive value for the time interval to onset of both renal failure and proliferative retinopathy.

Adolescent↗