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Biomedical subjects

J Texier

Publications and source records attributed to J Texier.

At least 19 recordsLinked to original sources
PubMed2001

[Surveillance and prognosis of "Ta" superficial tumors of the bladder. Homogeneous series of 138 cases followed for 1 to 18 years].

OBJECTIVE: To identify prognostic factors (risk of recurrence and risk of progression) and define the rules for the surveillance of stage Ta superficial bladder cancers, based on the follow-up of a homogeneous patient series. MATERIAL AND METHOD: 138 Ta bladder cancers were recruited from 1975 to 1995 and regularly followed by the same urologist. The follow-up was 1 to 18 years with a mean of 66 months and a median of 60 months. RESULTS: 30% of patients developed no recurrence (mean follow-up: 52 months). 70% developed one or several recurrences (mean follow-up: 80 months): 46% of Ta recurrences without progression and 24% of T > or = 1, with 10% of T > 1 recurrencesed. 13/138 patients died from bladder cancer, including 11 patients in less than 10 years. The risk of recurrence and the risk of progression were significantly correlated with: the macroscopic appearance of the cancer: size, number and extent of implantations, sessile or pedunculated nature, its site: slightly more serious on the fixed part of the organ, its clinical course assessed over the first 12 months: in patients without recurrence at 12 months: the risk of recurrence decreased from 70% to 35% the risk of deterioration decreased from 24% to 10%. However, this risk persisted in the long term: after more than 5 years without recurrence, 2 patients developed fatal recurrences, 11 and 15 years after the initial treatment. CONCLUSION: Although superficial, Ta bladder cancers are serious cancers. The risk of recurrence and progression justify close surveillance in the year following diagnosis. Subsequently, the frequency of follow-up can be adapted to the specific course of each case, but, regardless of these modalities, long-term (indefinite?) surveillance is recommended.

Adult↗
PubMed2001

[Surveillance and prognosis of "T1" superficial tumors of the bladder. Homogeneous series of 88 cases followed for 1 to 22 years].

OBJECTIVE: Define the prognostic factors (risk of recurrence and risk of progression) and the rules for surveillance of stage T1 papillary bladder tumours based on the clinical course of a homogeneous patient series. MATERIAL AND METHOD: 88 T1 bladder tumours recruited from 1975 to 1995 and regularly followed by the same urologist. The follow-up ranged from 1 to 22 years with a mean of 52 months and a median of 48 months. RESULTS: 26% patients relapsed (mean follow-up: 71 months) 74% developed one or more recurrences (mean follow-up: 48 months) with recurrences staged > T1 in 35% of cases. 29/88 patients died from invasive bladder cancer, 14 before 3 years, 19 before 5 years, 28 before 10 years. The risk of recurrence and progression was statistically significantly related to the macroscopic appearance of the tumour; size, number and extent of implantations; its rate of progression assessed by the frequency of recurrence. In patients with no recurrence at 12 months, the risk of recurrence decreased from 74% to 50% and the risk of progression decreased from 35% to 20%. In this cohort, neither histological grading of the initial tumour, nor the degree of invasion of the submucosal lamina propria appeared to modify the prognosis. CONCLUSION: Stage T1 papillary bladder tumours, generally considered to be a superficial tumours regardless of their histological grade, have a serious prognosis and warrant close endoscopic surveillance during the year following the diagnosis. The subsequent frequency of follow-up can then be adapted to the specific mode of progression of each case, but, regardless of this mode of progression, the authors recommend long-term (life-long?) surveillance.

Adult↗
PubMed1998

Severe infection caused by Stomatococcus mucilaginosus in a neutropenic patient: case report and review of the literature.

A 24-year-old female, in neutropenic phase after chemotherapy for acute myelogenous leukemia (on day 15) was admitted in intensive care unit for infectious pneumonia. Two strains of Stomatococcus mucilaginosus were isolated from peripheral blood cultures. No microorganisms were yielded from bronchoalveolar lavage. Patient's condition improved with prompt instigation of effective antibiotic therapy. This was the first case of septicemia and pneumonia, due to Stomatococcus mucilaginosus, in our unit. Only 26 cases occurring in neutropenic patients with underlying hematologic malignancies were reported in the literature and among these, only five cases with pneumonia were described. The complications of this normal inhabitant of the human oral cavity can be serious and fatal: septic shock, meningitis, acute respiratory distress syndrome. This study illustrate the possible virulence of Stomatococcus mucilaginosus in neutropenic patients.

Acute Disease↗
PubMed1988

[Early septicemia episodes in 143 bone marrow grafts].

Twenty-one early bacteremias have occurred before engraftment in 143 allogeneic bone marrow transplantation recipients. In the majority of cases (13/21) Gram positive cocci were isolated with a predominance of coagulase-negative staphylococci (62%). The analysis of the infection prevention program showed that: 1) the adjunction of vancomycin to a total gut decontamination did not decrease significantly the incidence of bacteremia caused by Gram positive cocci. 2) The isolation in laminar air flow room seems to decrease the severity of infections but does not influence their frequency.

Bone Marrow Transplantation↗
PubMed1986

[Intestinal decontamination in the neutropenic patient. Apropos of a prospective randomized study].

Sixty-five patients undergoing remission-induction chemotherapy for acute leukemia in a protected environment unit were randomly assigned to selective antimicrobial modulation of the intestinal flora (SAM) with trimethoprim-sulfamethoxazole, or total antibiotic decontamination (TAD) with gentamicin, vancomycin and colimycin. Digestive tract colonization with Streptococcus D was more prevalent in the SAM group (p less than 0.01); colonization with yeasts was more prevalent in the TAD group (p less than 0.001). However, there was no difference between the two groups as regards to clinically and microbiologically documented infections, septicemias and survival. Selective antimicrobial modulation with trimethoprim-sulfamethoxazole is as effective and cheaper than total antibiotic decontamination with gentamicin, vancomycin and colimycin.

Acute Disease↗
PubMed1984

[Experimental magnesium ammonium phosphate lithiasis induced by Ureaplasma in the rat].

Struvite urinary stones are commonly associated with infections by urease possessing bacteria (Proteus). Ureaplasma urealyticum, a genital mycoplasma, is predominantly located in the human genito-urinary tract and produces urease. Its possible role in the formation of infection stones was studied in the rat model described by Friedlander and Braude. Struvite bladder stones were produced in 60% of Sprague-Dawley male rats after infection of ureaplasmas (serotype 1, 2, 3, 7) into the renal medulla. Mycoplasma hominis, another genital mycoplasma, produced bladder stones in only 10% of animals. A kinetic study showed that pure struvite stones appeared into the bladder 4 to 5 days after inoculation and that U. urealyticum did not usually remain viable more than 6 days. Acetohydroxamic acid and doxycycline prevented the formation of the stones.

Animals↗
PubMed1984

[Mandibular bone tumors. Diagnostic difficulties].

A session of the "Société de Stomatologie et de Chirurgie maxillo-faciale de France" was devoted to a discussion of diagnostic difficulties in cases of mandibular bone tumors. Several case-reports were presented as a basis for comments on clinical and radiologic criteria of the benign or malignant nature of bone tumors, these being the foundation on which to establish the most effective surgical approach to adopt. Pre-operative biopsy is not considered essential when confirmation of diagnostic has been obtained.

Adult↗
PubMed1983

[Mycobacterium szulgai pulmonary mycobacteriosis, Apropos of a new case].

A case of pulmonary mycobacteriosis due to Mycobacterium szulgai is reported in a 58-year-old man. Clinical and radiological features suggested tuberculosis. The etiologic agent was M. szulgai which was recovered from six sputum samples. The condition has remained unchanged without therapy for four years.

Humans↗
PubMed1983

[Comparative bacteriostatic activity of 10 cephalosporins against 100 strains of Serratia].

The in vitro activity of 10 cephalosporins was evaluated against 100 different clinical isolates of Serratia. 90% of these strains were inhibited at the following concentrations (microgram/ml): ceftazidime = 0.5; ceftriaxon = 0.9; cefmenoxime = 1; lamoxactam = 1.1; cefotaxime = 1.25; cefotetan = 2; cefoperazone = 28; cefoxitine = 64; cefotiam = 80; ceforanide greater than 512. Ceftazidime was the most potent agent. Ceftriaxon, cefmenoxime, lamoxactam and cefotaxime had also a very high activity. All the strains were clinically susceptible to these 5 cephalosporins (MIC less than or equal to 16). The other cephalosporins were less active.

Cephalosporins↗
PubMed1983

[Malignant non-Hodgkin's lymphoma].

Rapid regression of all symptoms was obtained after moderate chemotherapy in two women aged 69 and 77 years respectively with malignant non-Hodgkin's lymphomas. Cervico-facial locations of these tumors are discussed in relation to definition, etiology, geographic factors, genetic markers, and associated immunologic disorders. Diagnosis requires a series of explorations including, obviously as a last resort, exploratory cervicotomy. Other regions may be involved and must be investigated, but lesions not affecting lymph nodes occur in only approximately 2 p. cent of patients with cervico-facial malignant non-Hodgkin's lymphoma (approximately 10 p. cent of all malignant non-Hodgkin's lymphomas). Other localizations include the hard palate, gums, sinuses, and salivary glands. Burkitt's lymphoma represents, on the contrary, 30 p. cent of malignant non-Hodgkin's lymphoma seen in European children. The different therapeutic modalities available are discussed.

Aged↗
PubMed1983

[Thrombopenia as the presenting symptom of acute disseminated lupus erythematosus: Moschcowitz's disease].

Possible relationships between Moschcowitz's disease and acute systemic lupus erythematosus are analyzed based on findings in one case. Initial exclusively buccal symptoms suggested a diagnosis of lupus, and then of Moschcowitz's disease leading to a fatal outcome. The main points discussed relate to diagnostic difficulties to enable distinction between the two diseases. A thrombotic thrombopenic purpura during the second phase of the disease showed a characteristic microangiopathy associated with a non-autoimmune hemolytic anemia and a schizocytosis: two forms of the affection are recognized, one with a chronic and one with an acute course. The latter, which has a fulminating progression leading to death, was that described in the case reported.

Adult↗
PubMed1981

[About five cases of cervico-facial actinomycosis (author's transl)].

Concerning five observations of cervico-facial actinomycosis in two hospital wards, the authors recall that this pathology, although rare, still exists. It appears as a chronic cellulitis, usually occurring among subjects lacking in dental hygiene. The authors insist on the necessity of asking for a bacteriological test by taking a sample of pus with a pipette to look for the responsible actinomyces. The cure consists in the extracting of the teeth concerned, the removal of the necrosed tissues, a drainage, and an antibiotic treatment based on high doses of Penicilline for about three months.

Actinomycosis, Cervicofacial↗
PubMed1975

[2 new cases of Klippel-Trenaunay syndrome].

After a brief account of the history and pathogeny, two cases are described of sub-angiomal bone hypo and hypertrophy. Other cases in the literature are recalled. Finally, a differential diagnosis is given.

Adult↗