PubMed Health⌕ Search

Biomedical subjects

J Thorson

Publications and source records attributed to J Thorson.

At least 19 recordsLinked to original sources

Ensuring the success of women faculty at AMCs: lessons learned from the National Centers of Excellence in Women's Health.

Since the early 1970s, the numbers of women entering medical school and, subsequently, academic medicine have increased substantially. However, women faculty have not advanced at the expected rate to senior academic ranks or positions of leadership. In 1996, to counter this trend, the U.S. Department of Health and Human Services (DHHS) Office on Women's Health included women's leadership as a required component of the nationally funded Centers of Excellence in Women's Health to identify effective strategies and initiate model programs to advance women faculty in academic medicine. The authors describe the experience of Centers at seven U.S. medical schools in initiating and sustaining leadership programs for women. The processes used for program formation, the current programmatic content, and program evaluation approaches are explained. Areas of success (e.g., obtaining support from the institution's leaders) and difficulties faced in maintaining an established program (such as institutional fiscal constraints and the diminishing time available to women to participate in mentoring and leadership activities) are reviewed. Strategies to overcome these and other difficulties (e.g., prioritize and tightly focus the program with the help of an advisory group) are proposed. The authors conclude by reviewing issues that programs for women in academic medicine will increasingly need to focus on (e.g., development of new kinds of skills; issues of recruitment and retention of faculty; and increasing faculty diversity).

Faculty, Medical↗

[Successful prevention of tractor accidents in Sweden].

A decrease in the incidence of tractor roll-over fatalities, from 15/100,000 farm tractors for the period 1957(60 to 0.1/100,000 for the period 1986(90, was associated with a corresponding increase in the proportion of farm tractors equipped with roll-over protection structures (ROPS) from 6 to 93 per cent. Thus, the Swedish approach to the prevention of serious injuries due to tractor roll-over, entailing the compulsory equipment of new tractors with ROPS from July 1st 1959, may be said to have been successful. No other country seems to have introduced such effective safety regulations for the prevention of these injuries.

Accidents, Occupational↗

The 14-3-3 proteins positively regulate rapamycin-sensitive signaling.

BACKGROUND: The kinase Tor is the target of the immunosuppressive drug rapamycin and is a member of the phosphatidylinositol kinase (PIK)-related kinase family. It plays an essential role in progression through the G1 phase of the cell cycle. The molecular details of Tor signaling remain obscure, however. RESULTS: We isolated two Saccharomyces cerevisiae genes, BMH1 and BMH2, as multicopy suppressors of the growth-inhibitory phenotype caused by rapamycin in budding yeast. BMH1 and BMH2 encode homologs of the 14-3-3 signal transduction proteins. Deletion of one or both BMH genes caused hypersensitivity to rapamycin in a manner that was dependent on gene dosage. In addition, alterations in the phosphopeptide-binding pocket of the 14-3-3 proteins had dramatically different effects on their ability to relieve the growth-arresting rapamycin phenotype. Mutations that prevented 14-3-3 from binding to a phosphoserine motif abolished its ability to confer rapamycin resistance. In contrast, substitution of two residues in 14-3-3 that surround these phosphoserine-binding sites conferred a dominant rapamycin-resistant phenotype. CONCLUSIONS: Our studies reveal 14-3-3 as an important component in rapamycin-sensitive signaling and provide significant new insights into the structure and function of 14-3-3 proteins.

14-3-3 Proteins↗

Vehicle-related fatalities among Swedish conscripts.

All traffic fatalities among conscripts in Sweden from 1979 through 1988 (N = 106) were studied. More than half (58%) of the victims were on leave, nearly one-third (30%) were traveling to or from the regiment, and 13 (12%) were on duty. Forty-one percent of the drivers on leave who were involved in crashes were inebriated; the mean blood alcohol concentration was 1.6 g/kg. Fifty-two percent of the conscripts on leave were injured in single-vehicle crashes. Fatalities occurring during travel to or from the regiment most often occurred in crashes with another vehicle (69%), and all the drivers were sober. At least one of the fatally injured drivers on duty was inebriated, and in another two crashes, safety belts were not used although this was compulsory for both passengers and drivers. We conclude that collective travel could reduce the danger in traveling to and from the regiment. In addition, identifying alcohol abusers and preventing them from driving is of prime importance. Increased use of safety belts and installation of airbags should also be beneficial as well.

Accidents, Traffic↗

Carbon monoxide suicide from car exhausts.

STUDY OBJECTIVE: the aim of the study was to analyse the victims and circumstances in carbon monoxide suicides from car exhausts in order to find strategies for mitigation of the suicide risk. DESIGN: necropsy, police and hospital records were scrutinized for 194 victims who committed suicide by carbon monoxide poisoning from car exhausts during a four-year period in Sweden. SETTING AND PARTICIPANTS: the State Institutes of Forensic Medicine in Umeå and Stockholm. RESULTS: a higher incidence (24.2/million population) was seen in the rural region than in the urban region (14.9). Males dominated (88%), most of them middle aged. Most victims committed suicide in a car outdoors. A vacuum cleaner tube connected to the compartment was most commonly used. Severe disease, mostly psychiatric, was seen in 61% of the victims. Drugs were detected in 8% of the victims under psychiatric treatment. In 37%, earlier suicide behaviour was documented. Suicide notes were found in 40%. Blood alcohol was detected in 51% of the victims and other drugs in 7%. CONCLUSIONS: environmental changes may reduce the number of carbon monoxide suicide from car exhausts, e.g. introduction of a law requiring catalyst exhaust, of automatic idling stop, and of exhaust pipes incompatible with vacuum cleaner tubes. The importance of accurate treatment of psychiatric patients is stressed.

Adult↗

Nicotinic receptor binding site probed with unnatural amino acid incorporation in intact cells.

The nonsense codon suppression method for unnatural amino acid incorporation has been applied to intact cells and combined with electrophysiological analysis to probe structure-function relations in the nicotinic acetylcholine receptor. Functional receptors were expressed in Xenopus oocytes when tyrosine and phenylalanine derivatives were incorporated at positions 93, 190, and 198 in the binding site of the alpha subunit. Subtle changes in the structure of an individual side chain produced readily detectable changes in the function of this large channel protein. At each position, distinct features of side chain structure dominated the dose-response relation, probably by governing the agonist-receptor binding.

Animals↗

National suicide prevention programme and railway suicide.

Suicidal behaviour is a public health problem closely related to other problems such as mental illness, abuse, violence and accidents. This approach is illustrated by the prevention of railway suicides. A theoretical framework is sketched, which allows for the use of principles from injury prevention in the prevention of suicide. ICD-9 encoded death certificates from 1974, 1980, 1986 and 1987 which concerned suicides and undetermined deaths on roads and railways were analysed (N = 294). Additional data were collected from autopsy, police and hospital protocols and from interviews with engine-drivers. Railroad victims dominated the sample (78% of cases). The mean age was 42 yr. Alcohol was detected in 27% of cases, drugs in 36% and severe illness (mostly psychiatric) in 57%. The relationship between types of collision and nature of injury is discussed. Environmental changes, such as changing the locomotive front design, are suggested as strategies for reducing accidents and suicides on railways.

Accidents, Traffic↗

Back pain: a study of twins.

To evaluate the relationship between genetic factors and back pain, 5029 MZ and 7876 DZ twin pairs were investigated by a questionnaire. The data were analyzed with regard to physical symptoms, eg, back pain, and certain work conditions. Pain was reported by about 17% of the male and 13% of the female twins in the material. The occurrence of back pain was strongly associated with work load, especially among the male twins. Twin concordance regarding back pain was considerably higher in MZ than in DZ twins. Of four groups who were studied, statistically significant differences between the two twin categories were observed in three cases. This result supports the assumption that a relationship exists between genetic factors and the occurrence of back pain. Official registrations for sick-leave pay in a sample of 247 twins confirmed the interview information on back pain. Just a few cases were wrongly classified, ie, they were sick-listed because of back pain but had stated no back pain in the questionnaire.

Adolescent↗

The accuracy and precision of the third mandibular molar as an indicator of chronological age.

The study was designed to investigate the accuracy and precision of the development of the third mandibular molar, determined on panoramic x-rays, as an indicator of chronological age- a method which is used in Sweden to estimate chronological age in certain young foreign individuals with uncertain birth records. Accuracy test: The mean difference between the estimated and true chronological age was determined in a sample of 372 14.5-24.5-year-old subjects. The data were arranged in subgroups according to sex and age. The accuracy test showed a systematic underestimation of age, increasing with age in both sexes. The 95 per cent confidence interval of the difference between estimated and true chronological age was large, about +/- 4.5 years in girls and +/- 2.8 years in boys. The association between dental age and chronological age, expressed in correlation coefficients, was poor. Precision test: The intra-examiner error was low but the 95 per cent confidence interval of the difference was large, +/- 0.8 years. The dental development of the third mandibular molar should not be used for estimation of chronological age in individual subjects, due to its very low accuracy.

Adolescent↗

CD4+ murine T cell clones that express high levels of immunoglobulin binding belong to the interleukin 4-producing T helper cell type 2 subset.

A panel of 20 murine CD4+ clones was examined for the presence of surface membrane receptors for IgA, IgM, IgD, IgE, and IgG. High level expression of multiple Fc receptors (FcRs) was found on all Th2 clones. FcR expression was low or undetected on the Th1 clones. The preferential expression of FcR on activated Th2 cells suggests potential mechanisms for immunoregulatory interactions with B cells.

Animals↗