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Biomedical subjects

J Thorup

Publications and source records attributed to J Thorup.

52 records · Page 3Linked to original sources
PubMed1985

Postoperative thromboembolic complications despite heparin prophylaxis in major abdominal surgery.

181 patients who received low-dose heparin prophylaxis in connection with major abdominal surgery were screened for postoperative thromboembolism by means of the 125 I-fibrinogen uptake test, venography and ventilation/perfusion lung scans. Among a number of potential risk factors analyzed only colonic surgery and preoperative anaemia were associated with significantly increased risk of postoperative thromboembolism.

Abdomen↗
PubMed1984

Clinical results of early and late operative correction of undescended testes.

Operative treatment of undescended testes was performed in 556 boys (695 testes). The histopathological changes in the testicular tissue were more severe in older patients. However, post-operative clinical results were found to be significantly better in boys treated immediately before puberty than in boys treated at an earlier age.

Adolescent↗
PubMed1984

Dihydroergotamine in prevention of infusion thrombophlebitis. A randomized trial.

The efficiency of subcutaneous dihydroergotamine in preventing infusion thrombophlebitis was assessed in a randomized trial. One hundred and fourteen postoperative patients were studied. They furnished a total of 160 infusion sites. The difference between treatment and control group with regard to incidence of infusion thrombophlebitis was not significant (p greater than 0.05). Accordingly dihydroergotamine has no substantial effect.

Clinical Trials as Topic↗
PubMed1983

Heparin with and without dihydroergotamine in prevention of thromboembolic complications of major abdominal surgery. A randomized trial.

We compared the results of dihydroergotamine mesylate administered with low-dose heparin sodium with those of low-dose heparin given alone in a randomized trial based on 181 patients who underwent major abdominal surgery. We found no significant difference in the incidence of thromboembolism between the two groups but a higher incidence of abnormal fibrinogen uptake test results in patients given heparin alone. There was no difference in hemoglobin levels and the number of blood transfusions. We concluded that there is little, if any, clinical advantage in adding dihydroergotamine to low-dose heparin to prevent thromboembolic complications in patients who have undergone major abdominal surgery.

Abdomen↗
PubMed1983

Dihydroergotamine in postoperative ileus.

The effects of dihydroergotamine (DHE) on postoperative ileus after major abdominal surgery were studied. Forty-one patients received 0.5 mg DHE subcutaneously twice a day from the day of surgery to the seventh postoperative day. Thirty-three patients served as controls. There were no significant differences in the time to the first postoperative passage of flatus or delivery of stools nor in the quantity of laxatives given. It is concluded that DHE does not reduce the duration of postoperative ileus.

Adult↗
PubMed1983

Permeability and ultrastructure of human bladder epithelium.

Leakage of tight junctions as observed with electron microscopy and demonstration of solute transport across bladder epithelium was investigated in 13 patients with different bladder diseases: urinary retention and infection, bladder tumours and interstitial cystitis. The latter group showed consistent leakage of solutes through the urothelium. Electron microscopy revealed leaky tight junctions. This finding might be helpful in establishing the histological criteria and explain the pathogenesis of interstitial cystitis.

Adult↗
PubMedDate not supplied

Pulmonary function, pain, and fatigue after laparoscopic cholecystectomy.

OBJECTIVE: To assess pulmonary function, pain, and fatigue after elective laparoscopic cholecystectomy. DESIGN: Prospective study. SETTING: University hospital. SUBJECTS: The first 53 patients listed to undergo laparoscopic cholecystectomy. MAIN OUTCOME MEASURES: Assessments of pain, peak flow, and the subjective feeling of fatigue before, and 6 hours after, operation, and then daily for the first week. RESULTS: Pain scores at rest and while coughing and fatigue score were less than have been reported after open cholecystectomy. Peak flow was reduced 6 hours after operation (p < 0.01) but less than has been reported after open surgery, and it returned to the preoperative value within the study period. CONCLUSION: The less disturbance of pulmonary function and the lower pain and fatigue scores may explain the observed early discharge from hospital and the rapid mobilisation, including ability to go to work, in patients who have undergone laparoscopic cholecystectomy.

Adolescent↗