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Biomedical subjects

J Tiekso

Publications and source records attributed to J Tiekso.

11 recordsLinked to original sources
PubMed1992

Multifactorial modeling for root caries prediction.

The study was part of a series of investigations aiming at the development of diagnostic caries tests for screening of risk subjects. The material consisted of 100 adult subjects (mean 62 yr, range 47-79 yr), 50 of these under chronic medication. The series of tests included two chairside registrations, i.e. incipient demineralization of exposed root surfaces without cavitation (RD 1) and quantitation of visible plaque (VPT%), three microbiological tests for mutans streptococci, lactobacilli, and candida/yeasts and three tests on stimulated saliva, i.e. secretion rate, buffering capacity and sucrase activity. A thorough clinical examination was conducted at the baseline and 1-yr registration phases, caries being registered at a tooth surface level according to WHO recommendations separately for coronal and root caries. Considerably more root caries than coronal caries developed during the observation period. For coronal caries increment, the predictive value of any of the tests was not significant. For root caries, however, the association between several tests and prospective caries increment was significant. Subsequent multifactorial modeling yielded the highest predictive value to the combination of Past Root Caries Experience (OR 25.0, Visible Plaque (OR 4.2), Candida (OR 8.0) and Lactobacilli (OR 5.8). A positive finding of Past Root Caries (RDFS) or the combination of the other three tests (Can, LB, VPT%) as criteria for selection in screening for root caries produced good accuracy (84.0) and a relative risk of 5.5.

Aged↗
PubMed1992

[The assessment of the caries risk in young adults].

Several factors for caries prediction have been proved in a one-year follow-up study on 73 patients. The white-spot lesions have proved to be a good criteria for caries prediction in this population. These lesions could be combined with the microbiological tests Dentocult SM and Oricult N or with the determination of the buffer capacity (Dentobuff), which did not much improve the prediction.

Adult↗
PubMed1991

Gingival crevicular fluid plasmin activity in different clinical conditions and after periodontal treatment.

Plasmin is an important enzyme in the process of wound healing and it has been suggested that it plays a role in the pathogenesis and healing of periodontal diseases. In this study, plasmin activity in crevicular fluid (CF) was measured in different clinical conditions and after periodontal treatment. 152 CF samples were collected with paper strips from 12 subjects. Five other subjects received a single periodontal treatment after the first sample collection and the post-treatment samples were collected 2, 5, 10, 20 and 40 days thereafter. The individual strips were placed immediately on plasminogen-free fibrin plates or in plastic vials containing sterile saline. The vials were agitated and 20 microliters of each solution was pipetted onto fibrin plates. The remaining solution was used in protein analysis. The plates were incubated for 24 hrs at 37 degrees C and the activity of plasmin determined by weighing the fibrin liquified by the samples. The variation of CF plasmin activity in different pockets within individuals was larger than between the subjects. There was a weak positive correlation between CF plasmin activity and the amount of plaque, bleeding tendency, pocket depth and bone loss by x-ray. However, plasmin concentration (units of plasmin activity per CF volume) did not correlate with clinical parameters. A weak negative correlation between plasmin activity per volume and the amount of CF was seen. Neither did CF protein concentration correlate with the clinical parameters. Periodontal treatment resulted in a dramatic decrease in plasmin activity. In 20 days the activity returned to pre-operative levels in four subjects out of five.

Adult↗
PubMed1989

Long-term effect of xylitol chewing gum on dental caries.

About 85% (n = 269) of the subjects who participated in the Ylivieska follow-up studies on the effect of xylitol chewing gum on dental caries during 1982-84 or 1982-85 were re-examined in 1987 for the analysis of possible long-term preventive effects. Further caries reduction was found 2 or 3 yr after the discontinuation of the use of xylitol. The effect was especially marked in girls; the reduction in caries increment in the post-use years was 60% for the 2-yr users, suggesting that more pronounced caries reduction was associated with the most regular use of xylitol. In teeth erupting during the first year of the use of xylitol gum the long-term preventive effect was greater than in other teeth. Several explanations are suggested: lasting effect of the microbiological changes in the mouth, bacterial colonization on newly erupted teeth by organisms other than S. mutans, and/or thorough maturation of the teeth under favorable physico-chemical circumstances. The results suggest that the value of xylitol in caries prevention depends on the timing of the treatment in relation to the development of the dentition.

Adolescent↗
PubMed1989

Oral biochemical status and depression of Streptococcus mutans in children during 24- to 36-month use of xylitol chewing gum.

Plaque and whole saliva samples were collected from initially 11- to 12-year-old children randomly chosen from two groups which participated in a 2- to 3-year field trial designed to test the efficacy of xylitol chewing gums in caries prevention. No initial differences were observed between the groups with regard to the plaque levels of Streptococcus mutans, but at the end of the 2-year xylitol gum regimen, the levels were smaller (p less than 0.05) in children using xylitol gum than in control children. In a similar follow-up study on children who were considered to be at high risk with regard to dental caries and who continued the study over a 3rd year, the xylitol-consuming subjects showed at the end of the study significantly smaller (p less than 0.004) salivary S. mutans counts than the control children. These effects were achieved after using up to 3 xylitol gums/day (daily xylitol dose per child was 7-10 g). Salivary flow rate and several salivary chemical parameters did not change.

Amino Acids↗
PubMed1988

Xylitol chewing gum in caries prevention: a field study in children.

As the prevalence of dental caries decreases in industrialized nations like the United States, it simultaneously increases in developing nations and Third World countries. The decrease in the West is attributed to increased use of fluorides, but the increase in developing countries has been explained by an increase in the consumption of sugar. As this information continues to propel researchers to find sucrose substitutes, xylitol has been singled out as a proposed sucrose replacement. The question tackled by this study was: Can the daily use of chewing gum containing xylitol increase the efficacy of the existing caries-preventive measures now regularly used for 11- to 15-year-old children in most industrialized western countries?

Adolescent↗
PubMed1985

Effect of war-time dietary changes on dental health of Finns 40 years later.

During the Second World War the incidence of dental caries diminished due to reduced sugar consumption. It is possible that this reduction was more permanent in those age cohorts whose teeth erupted during the war because the teeth had an opportunity to mature before the caries attack. The aim of our study was to establish whether this reduction could still be demonstrated 40 yr after the war. The material consisted of consecutive age cohorts born in 1922-48 from the large Mini-Finland Oral Health Survey representing Finnish adults aged 30 yr or over in 1979. The results showed a systematic difference in the number of caries free premolars and second molars between the age cohort born in 1931-33 and the younger and older age groups in favor of the group 1931-33, indicating that the first years after eruption may have had a long-term effect on the health of the teeth.

Adult↗
PubMed1985

Collaborative WHO xylitol field studies in Hungary. I. Three-year caries activity in institutionalized children.

The aim of this 3-year field study was to assess the value of partial substitution of sucrose with peroral xylitol (14-20 g/day) as a caries-preventive measure (X group) in comparison with systemic administration of fluoride (F group) and restorative treatment procedures solely (C group). An F dentifrice was used unsupervised in the X and F groups, the former containing 10% xylitol. The C group used customary, predominantly F-free dentifrices distributed by the local health authorities. The final material consisted of 689 institutionalized children (6-11 years). Caries was scored yearly in duplicate by two continuously calibrated teams. At base line the X group had a significantly higher caries prevalence than the F and C groups. The 3-year DMFS increment was 4.2 in the X group, 6.5 in the F group, and 7.7 in the C group. The corresponding ratio (RS) between caries incidence and the tooth surface population at risk was RSx, 4.9; RSF, 6.6; and RSC, 8.6. It is concluded that dietary xylitol in solid sweets resulted in a lower increment of caries than obtained in the F and C groups (p less than 0.001, covariance analysis, with base-line prevalence, number of permanent teeth, and visible plaque index as covariants).

Animals↗
PubMed1985

Collaborative WHO xylitol field studies in Hungary. VII. Two-year caries incidence in 976 institutionalized children.

The aim was to assess caries increment as influenced by partial substitution of sucrose by xylitol (X group) over a 2-year period in comparison with systemic fluoride (F group) and restorative treatment only (C group). The study differed from the 3-year field study of the same series primarily in that existing base-line differences were eliminated because the protocol required that all the new subjects entering the institutions in the 1st year were to be included for a 2-year trial. During this period the number of dropouts was 243 (19.9% of all subjects), the final material consisting of 976 children (6-12 years old). The 2-year DMFS increment was 3.8 in the X group, 4.8 in the F group, and 6.0 in the C group. The corresponding ratio (RS) between caries incidence and the tooth surface population at risk was RSX, 4.5; RSF, 5.5; and RSC, 7.5. The xylitol regimen resulted in a lower increment of caries than measured in the F and C groups (p less than 0.001; convariance analysis, with base-line prevalence, number of permanent teeth, and visible plaque index as covariants.

Cariostatic Agents↗