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Biomedical subjects

J Tignol

Publications and source records attributed to J Tignol.

At least 19 recordsLinked to original sources
PubMed1992

Long-term use of tianeptine in 380 depressed patients.

Tianeptine is a new tricyclic compound whose principal action is to increase the reuptake of serotonin. In a multicentre trial in which 380 depressed patients were treated for one year, tianeptine produced a significant reduction in the MADRS scores from day 14, with a sustained reduction maintained for up to 12 months; other measures of efficacy (HRSA, HSCL, and CGI) also reflected the improvement. Only 11% of patients withdrew because of recurrence of depression and 2% because of side-effects, which were mainly drowsiness, irritability, and gastrointestinal disturbance. Apart from a minor reduction in heart rate, unaccompanied by any conduction changes, no clinically relevant changes in vital signs or laboratory tests were seen. Seven subjects who attempted suicide by tianeptine overdose had favourable outcomes, in spite of also taking other psychotropic drugs or alcohol. No evidence of tolerance or withdrawal symptoms was seen after treatment was stopped. These results suggest that tianeptine has the potential to provide safe antidepressant activity in both the acute and chronic phases of treatment.

Adolescent↗
PubMed1992

Paroxetine in the treatment of melancholia and severe depression.

Meta-analyses of the worldwide paroxetine database assessed the efficacy of this compound in the treatment of both DSM-III defined melancholia and hospitalised patients with severe depression (HAMD > or = 25). The analysis for melancholia included 178 paroxetine treated patients and 66 patients treated with placebo. Paroxetine was significantly superior to placebo in the treatment of melancholia and a clear dose-response relationship was established. The meta-analysis for severely depressed hospitalised patients included 109 paroxetine treated patients and 107 patients treated with a tricyclic/tetracyclic control. Paroxetine and active controls showed comparable efficacy in the treatment of severely depressed hospitalised patients.

Adult↗
PubMed1990

Transcutaneous electrical stimulation with Limoge current potentiates morphine analgesia and attenuates opiate abstinence syndrome.

Transcutaneous electrostimulation is a somewhat controversial technique used in the management of the opiate withdrawal syndrome. We report an animal study of a particular transcutaneous electrostimulation called transcutaneous cranial electrostimulation, based on a technique used for many years on heroin addicts for the rapid severance of their addiction, which has been validated in a clinical setting by a double-blind trial. This technique involves the application of an intermittent high-frequency current (Limoge's current). Our experimental data show that this transcutaneous cranial electrostimulation increases morphine analgesia by threefold on the tail flick latency measure and produces a 48% attenuation of the abstinence syndrome observed after abrupt cessation of morphine administration. These results were obtained using a double-blind paradigm.

Animals↗
PubMed1989

[Sexual dysfunction in males in long-term hemodialysis].

A quick survey of the literature and the author's own observations in 93 males in dialysis enable them to define the model of sexual dysfunction affecting this kind of patients. Psychological, organic and iatrogenic factors are often linked to create complex troubles, often minimized by the patients themselves. It is still difficult to know whether the important biological - in particular hormonal - disorders necessarily induce impotence. Big efforts in the research and the management of these patients are needed to help them in improving their quality of life.

Adaptation, Physiological↗
PubMed1978

[Disinhibition and its risks].

The authors point out clinically the risks of desinhibition in psychiatry. The classical risk of suicide by suppression of inhibition with melancholic patients is well known and prevented. The main risk for neurotic patients is that of trying to get desinhibition by means of toxicomanic behavior essentially though alcoholism. As far as psychoses are concerned, the risk seems to be mainly that the psychiatrist might misunderstand the concept of desinhibition and make a wrong utilization of desinhibitory treatments. At last, the "institutional" desinhibition constitutes a misunderstanding for psychopathic personnalities.

Adjustment Disorders↗