Biomedical subjects

J Timar

Publications and source records attributed to J Timar.

57 records · Page 4Linked to original sources

PubMedDate not supplied

The effect of (-) deprenyl (selegiline) on different behavioral changes induced by dopamine agonists in the rat.

The effect of (-) deprenyl was investigated both on the stereotyped behavior and on other types of activities induced by various dopamine (DA) agonists. (-) Deprenyl was given in a single dose, 1 h prior to the DA agonists. 1-2 mg/kg sc (-) deprenyl decreased the stereotypy induced by amphetamine (AMPH, 2.5 mg/kg sc), but 20 mg/kg was needed to reduce the stereotypy-inducing effect of apomorphine (APO, 0.3 mg/kg sc). The stereotypy-inducing effect of phenyl-ethyl-amine (PEA, 40 mg/kg sc) was significantly enhanced by 0.25 mg/kg sc (-) deprenyl pretreatment. The PEA or AMPH-induced increase in the horizontal activity (locomotion) and the vertical activity (rearing) remained unchanged after a single dose of (-) deprenyl, showing that this drug acts primarily on the nigro-striatal dopaminergic system.

Amphetamine↗

PubMedDate not supplied

Lectin-binding pattern in human non-Hodgkin lymphoma xenografts.

The glycan profile of cell surface proteins has been studied on three human non-Hodgkin lymphoma xenografts of B-cell origin using a panel of biotinylated lectins. All three lines showed a more heterogeneous lectin-binding pattern than normal peripherial blood lymphocytes (PBLs) involving both the inner core and antenna part of the glycans. The conservative inner core (N-N-acetylchitobiose and oligomannose) was similar but fucosylated to various extents in the different lymphomas. The structure of the antennae of PBLs was characterized by glcNac-gal and galNac-gal-Sa sequences, while in lymphomas additional asialo as well as sialylated galNac containing antennae have been identified. This study suggests that NHLs sharing many immunophenotypic features show intertumoral differences in their lectin-binding pattern.

Animals↗

PubMedDate not supplied

Death rate in patients submitted to the surgical treatment of fracture of the proximal femur.

The death rate 6 and 12 months after surgery in 389 patients who had been treated for fracture of the proximal femur between 1989 and 1993 (1st semester) was studied. All of the patients submitted to surgery were traced through the official records on the population of the City of Padova. The overall death rate after 6 months was 16%, that after 12 months 23%. The best survival rate was observed in patients who had been submitted to gamma nail arthroplasty (p < 0.01).

Age Factors↗