Biomedical subjects
J Timmis
Publications and source records attributed to J Timmis.
An artificial immune system for data analysis.
We present a simplified view of those parts of the human immune system which can be used to provide the basis for a data analysis tool. The motivation for and reasoning behind such a model is given and the desire for a 'transparent' model and meaningful visualization and interpretation techniques is noted. A minimalist formulation of an artificial immune system and some of its behaviour is described. A simple implementation and a suitable visualization technique are demonstrated using some trivial data and the famous 'iris' data set.
Quantitative regulation of gene activity in plants.
The regulation of activity of ribosomal RNA genes has been studied in euploid and aneuploid varieties of hyacinth. The gene/gene product relationship was determined by measuring the specific gene product (stable rRNA) and the total gene product (protein) in varieties with different dosages of rRNA genes. The results show that the cellular rRNA content is positively regulated, that maximum gene utilization is not normally employed, and that the degree of utilization responds to the total genome rather than to the specific rRNA gene dosage. The mechanism of control of this regulation appears to be at the transcriptional level.